Temporal Ensemble Logic

We introduce Temporal Ensemble Logic (TEL), a monadic, first-order modal logic for linear-time temporal reasoning. TEL includes primitive temporal constructs such as ``always up to t time later'' (Boxt), ``sometimes before t time in the future'' (Diamondt), and ``t-time later'' varphit. TEL has been motivated from the requirement for rigor and reproducibility for cohort specification and discovery in clinical and population health research, to fill a gap in formalizing temporal reasoning in biomedicine. Existing logical frameworks such as linear temporal logic are too restrictive to express temporal and sequential properties in biomedicine, or too permissive in semantic constructs, such as in Halpern-Shoham logic, to serve this purpose. In this paper, we first introduce TEL in a general set up, with discrete and dense time as special cases. We then focus on the theoretical development of discrete TEL on the temporal domain of positive integers mathbbN^+, denoted as rm TEL_mathbbN^+. rm TEL_mathbbN^+ is strictly more expressive than the standard monadic second order logic, characterized by B"uchi automata. We present its formal semantics, a proof system, and provide a proof for the undecidability of the satisfiability of rm TEL_mathbbN^+. We also include initial results on expressiveness and decidability fragments for rm TEL_mathbbN^+, followed by application outlook and discussions.