Snuffy: Efficient Whole Slide Image Classifier
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Abstract (arXiv)
Whole Slide Image (WSI) classification with multiple instance learning (MIL) in digital pathology faces significant computational challenges. Current methods mostly rely on extensive self-supervised learning (SSL) for satisfactory performance, requiring long training periods and considerable computational resources. At the same time, no pre-training affects performance due to domain shifts from natural images to WSIs. We introduce Snuffy architecture, a novel MIL-pooling method based on sparse transformers that mitigates performance loss with limited pre-training and enables continual few-shot pre-training as a competitive option. Our sparsity pattern is tailored for pathology and is theoretically proven to be a universal approximator with the tightest probabilistic sharp bound on the number of layers for sparse transformers, to date. We demonstrate Snuffy's effectiveness on CAMELYON16 and TCGA Lung cancer datasets, achieving superior WSI and patch-level accuracies. The code is available on https://github.com/jafarinia/snuffy.
Key facts. Cited by 6 papers in the map (data through 7 Oct 2026). Builds on 35 of its 54 references that are in the map. First posted on arXiv 15 Aug 2024.
Builds on
35 of 54 references.
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Built on by
Citing papers per year: 2025: 4; 2026: 2.
6 papers.
- 2025Contrastive Integrated Gradients: A Feature Attribution-Based Method for Explaining Whole Slide Image Classificationcited by 3
- 2025FrameShield: Adversarially Robust Video Anomaly Detectioncited by 2
- 2025GMAT: Grounded Multi-Agent Clinical Description Generation for Text Encoder in Vision-Language MIL for Whole Slide Image Classificationcited by 1
- 2025Diagnose Like A REAL Pathologist: An Uncertainty-Focused Approach for Trustworthy Multi-Resolution Multiple Instance Learningcited by 0
- 2026Domain Adaptation Without the Compute Burden for Efficient Whole Slide Image Analysiscited by 0
- 2026Learning Where to Focus: Self-Supervised Multi-Scale ViTs for Histopathologycited by 0
- 2026Learning Where to Focus: Self-Supervised Multi-Scale ViTs for Histopathology16 Sep 2026
- 2026Domain Adaptation Without the Compute Burden for Efficient Whole Slide Image Analysis16 Mar 2026
- 2025Contrastive Integrated Gradients: A Feature Attribution-Based Method for Explaining Whole Slide Image Classification11 Nov 2025
- 2025Diagnose Like A REAL Pathologist: An Uncertainty-Focused Approach for Trustworthy Multi-Resolution Multiple Instance Learning9 Nov 2025
- 2025FrameShield: Adversarially Robust Video Anomaly Detection24 Oct 2025
- 2025GMAT: Grounded Multi-Agent Clinical Description Generation for Text Encoder in Vision-Language MIL for Whole Slide Image Classification2 Aug 2025