A Graph Signal Processing Perspective of Network Multiple Hypothesis Testing with False Discovery Rate Control

We consider a multiple hypothesis testing problem in a sensor network over the joint spatio-temporal domain. The sensor network is modeled as a graph, with each vertex representing a sensor and a signal over time associated with each vertex. We assume a hypothesis test and an associated p-value for every sample point in the joint spatio-temporal domain. Our goal is to determine which points have true alternative. By parameterizing the unknown p-value distribution under the alternative and the prior probabilities of hypotheses being null with a bandlimited generalized graph signal, we can obtain consistent estimates for them. Consequently, we also obtain an estimate of the local false discovery rates (lfdr). We prove that by using a step-up procedure on the estimated lfdr, we can achieve asymptotic false discovery rate control at a pre-determined level. Numerical experiments validate the effectiveness of our approach compared to existing methods.