MHNet: Multi-view High-order Network for Diagnosing Neurodevelopmental Disorders Using Resting-state fMRI
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Abstract (arXiv)
Background: Deep learning models have shown promise in diagnosing neurodevelopmental disorders (NDD) like ASD and ADHD. However, many models either use graph neural networks (GNN) to construct single-level brain functional networks (BFNs) or employ spatial convolution filtering for local information extraction from rs-fMRI data, often neglecting high-order features crucial for NDD classification. Methods: We introduce a Multi-view High-order Network (MHNet) to capture hierarchical and high-order features from multi-view BFNs derived from rs-fMRI data for NDD prediction. MHNet has two branches: the Euclidean Space Features Extraction (ESFE) module and the Non-Euclidean Space Features Extraction (Non-ESFE) module, followed by a Feature Fusion-based Classification (FFC) module for NDD identification. ESFE includes a Functional Connectivity Generation (FCG) module and a High-order Convolutional Neural Network (HCNN) module to extract local and high-order features from BFNs in Euclidean space. Non-ESFE comprises a Generic Internet-like Brain Hierarchical Network Generation (G-IBHN-G) module and a High-order Graph Neural Network (HGNN) module to capture topological and high-order features in non-Euclidean space. Results: Experiments on three public datasets show that MHNet outperforms state-of-the-art methods using both AAL1 and Brainnetome Atlas templates. Extensive ablation studies confirm the superiority of MHNet and the effectiveness of using multi-view fMRI information and high-order features. Our study also offers atlas options for constructing more sophisticated hierarchical networks and explains the association between key brain regions and NDD. Conclusion: MHNet leverages multi-view feature learning from both Euclidean and non-Euclidean spaces, incorporating high-order information from BFNs to enhance NDD classification performance.
Key facts. Cited by 3 papers in the map (data through 7 Oct 2026). Builds on 19 of its 90 references that are in the map. First posted on arXiv 3 Jul 2024.
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19 of 90 references.
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7 more
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Citing papers per year: 2024: 1; 2025: 2.
3 papers.
- 2024STARFormer: A Novel Spatio-Temporal Aggregation Reorganization Transformer of FMRI for Brain Disorder Diagnosiscited by 2
- 2025Information Bottleneck-Guided Heterogeneous Graph Learning for Interpretable Neurodevelopmental Disorder Diagnosiscited by 2
- 2025LEL: Lipschitz Continuity Constrained Ensemble Learning for Efficient EEG-Based Intra-subject Emotion Recognitioncited by 1
- 2025LEL: Lipschitz Continuity Constrained Ensemble Learning for Efficient EEG-Based Intra-subject Emotion Recognition12 Apr 2025
- 2025Information Bottleneck-Guided Heterogeneous Graph Learning for Interpretable Neurodevelopmental Disorder Diagnosis28 Feb 2025
- 2024STARFormer: A Novel Spatio-Temporal Aggregation Reorganization Transformer of FMRI for Brain Disorder Diagnosis31 Dec 2024