On-the-fly Definition Augmentation of LLMs for Biomedical NER
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Abstract (arXiv)
Despite their general capabilities, LLMs still struggle on biomedical NER tasks, which are difficult due to the presence of specialized terminology and lack of training data. In this work we set out to improve LLM performance on biomedical NER in limited data settings via a new knowledge augmentation approach which incorporates definitions of relevant concepts on-the-fly. During this process, to provide a test bed for knowledge augmentation, we perform a comprehensive exploration of prompting strategies. Our experiments show that definition augmentation is useful for both open source and closed LLMs. For example, it leads to a relative improvement of 15% (on average) in GPT-4 performance (F1) across all (six) of our test datasets. We conduct extensive ablations and analyses to demonstrate that our performance improvements stem from adding relevant definitional knowledge. We find that careful prompting strategies also improve LLM performance, allowing them to outperform fine-tuned language models in few-shot settings. To facilitate future research in this direction, we release our code at https://github.com/allenai/beacon.
Key facts. Cited by 9 papers in the map (data through 7 Oct 2026). Builds on 27 of its 38 references that are in the map. First posted on arXiv 29 Mar 2024.
Builds on
27 of 38 references.
References · 27
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15 more
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Built on by
Citing papers per year: 2024: 5; 2025: 2; 2026: 2.
9 papers.
- 2024LLMs are not Zero-Shot Reasoners for Biomedical Information Extractioncited by 9
- 2024FactEHR: A Dataset for Evaluating Factuality in Clinical Notes Using LLMscited by 5
- 2024Disease Entity Recognition and Normalization is Improved with Large Language Model Derived Synthetic Normalized Mentionscited by 3
- 2024Inferring Scientific Cross-Document Coreference and Hierarchy with Definition-Augmented Relational Reasoningcited by 2
- 2025EvidenceBench: A Benchmark for Extracting Evidence from Biomedical Paperscited by 2
- 2024MultiADE: A Multi-domain Benchmark for Adverse Drug Event Extractioncited by 1
- 2025Ontology-Guided Query Expansion for Biomedical Document Retrieval using Large Language Modelscited by 0
- 2026A Semi-Automated Annotation Workflow for Paediatric Histopathology Reports Using Small Language Modelscited by 0
- 2026Evaluating Large Language Models on Misconceptions in Multi-Turn Medical Conversationscited by 0
- 2026Evaluating Large Language Models on Misconceptions in Multi-Turn Medical Conversations14 Jul 2026
- 2026A Semi-Automated Annotation Workflow for Paediatric Histopathology Reports Using Small Language Models5 Apr 2026
- 2025Ontology-Guided Query Expansion for Biomedical Document Retrieval using Large Language Models15 Aug 2025
- 2025EvidenceBench: A Benchmark for Extracting Evidence from Biomedical Papers25 Apr 2025
- 2024FactEHR: A Dataset for Evaluating Factuality in Clinical Notes Using LLMs17 Dec 2024
- 2024Disease Entity Recognition and Normalization is Improved with Large Language Model Derived Synthetic Normalized Mentions10 Oct 2024
- 2024Inferring Scientific Cross-Document Coreference and Hierarchy with Definition-Augmented Relational Reasoning23 Sep 2024
- 2024LLMs are not Zero-Shot Reasoners for Biomedical Information Extraction22 Aug 2024
- 2024MultiADE: A Multi-domain Benchmark for Adverse Drug Event Extraction28 May 2024