WsiCaption: Multiple Instance Generation of Pathology Reports for Gigapixel Whole-Slide Images
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Abstract (arXiv)
Whole slide images are the foundation of digital pathology for the diagnosis and treatment of carcinomas. Writing pathology reports is laborious and error-prone for inexperienced pathologists. To reduce the workload and improve clinical automation, we investigate how to generate pathology reports given whole slide images. On the data end, we curated the largest WSI-text dataset (PathText). In specific, we collected nearly 10000 high-quality WSI-text pairs for visual-language models by recognizing and cleaning pathology reports which narrate diagnostic slides in TCGA. On the model end, we propose the multiple instance generative model (MI-Gen) which can produce pathology reports for gigapixel WSIs. We benchmark our model on the largest subset of TCGA-PathoText. Experimental results show our model can generate pathology reports which contain multiple clinical clues and achieve competitive performance on certain slide-level tasks. We observe that simple semantic extraction from the pathology reports can achieve the best performance (0.838 of F1 score) on BRCA subtyping surpassing previous state-of-the-art approaches. Our collected dataset and related code are available.
Key facts. Cited by 31 papers in the map (data through 14 Oct 2026). Builds on 20 of its 29 references that are in the map. First posted on arXiv 27 Nov 2023.
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References · 20
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- 2020Dual-stream Multiple Instance Learning Network for Whole Slide Image Classification with Self-supervised Contrastive Learningcited by 478
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- 2022Scaling Vision Transformers to Gigapixel Images via Hierarchical Self-Supervised Learningcited by 359
8 more
- 2022DTFD-MIL: Double-Tier Feature Distillation Multiple Instance Learning for Histopathology Whole Slide Image Classificationcited by 256
- 2017On the Automatic Generation of Medical Imaging Reportscited by 216
- 2022Benchmarking Self-Supervised Learning on Diverse Pathology Datasetscited by 150
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Citing papers per year: 2024: 4; 2025: 5; 2026: 22.
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- 2024HistGen: Histopathology Report Generation via Local-Global Feature Encoding and Cross-modal Context Interactioncited by 43
- 2024WSI-LLaVA: A Multimodal Large Language Model for Whole Slide Imagecited by 40
- 2024CPath-Omni: A Unified Multimodal Foundation Model for Patch and Whole Slide Image Analysis in Computational Pathologycited by 34
- 2025Historical Report Guided Bi-modal Concurrent Learning for Pathology Report Generationcited by 7
- 2026PathNavigate: A Training-Free Pathology Agent with Surprise-Guided Scan and Shared Slide Memory for Whole-Slide Image VQAcited by 7
- 2025Content Generation Models in Computational Pathology: A Comprehensive Survey on Methods, Applications, and Challengescited by 5
- 2026Act Like a Pathologist: Tissue-Aware Whole Slide Image Reasoningcited by 5
- 2025PolyPath: Adapting a Large Multimodal Model for Multi-slide Pathology Report Generationcited by 4
- 2026QCAgent: An agentic framework for quality-controllable pathology report generation from whole slide imagecited by 4
- 2026LAMMI-Pathology: A Tool-Centric Bottom-Up LVLM-Agent Framework for Molecularly Informed Medical Intelligence in Pathologycited by 3
- 2026Designing UNICORN: a Unified Benchmark for Imaging in Computational Pathology, Radiology, and Natural Languagecited by 3
- 2026RANGER: Sparsely-Gated Mixture-of-Experts with Adaptive Retrieval Re-ranking for Pathology Report Generationcited by 3
19 more
- 2026NuNext: Reframing Nucleus Detection as Next-Point Detectioncited by 2
- 2024Learning Spatial-Preserving Hierarchical Representations for Digital Pathologycited by 1
- 2025CLIP-IT: CLIP-based Pairing for Histology Images Classificationcited by 1
- 2026Multi-View Stenosis Classification Leveraging Transformer-Based Multiple-Instance Learning Using Real-World Clinical Datacited by 1
- 2026PathMem: Toward Cognition-Aligned Memory Transformation for Pathology MLLMscited by 1
- 2026Semantic Context-aware mOdality fUsion Transformer (SCOUT): A Context-Aware Multimodal Transformer for Concept-Grounded Pathology Report Generationcited by 1
- 2026Auditing Data Leakage in Whole-Slide Image Multimodal Benchmarkscited by 1
- 2025Any-to-Any Learning in Computational Pathology via Triplet Multimodal Pretrainingcited by 0
- 2026PA-MIL: Phenotype-Aware Multiple Instance Learning Guided by Language Prompting and Genotype-to-Phenotype Relationshipscited by 0
- 2026Footprint-Guided Exemplar-Free Continual Histopathology Report Generationcited by 0
- 2026Layout-Guided Controllable Pathology Image Generation with In-Context Diffusion Transformerscited by 0
- 2026PBSBench: A Multi-Level Vision-Language Framework and Benchmark for Hematopathology Whole Slide Image Interpretationcited by 0
- 2026Prior-Anchored Debiasing for Long-Tailed Multi-Organ Pathology Report Generationcited by 0
- 2026LaGuadia: Language-Guided Adaptive Distillation from Pathology Foundation Modelscited by 0
- 2026PathReportEval: A Systematic Benchmark for Pathology Report Generationcited by 0
- 2026Pathologist Attention-Aligned Report Generation for Prostate Histopathologycited by 0
- 2026From Multi-Resolution Cells to Gigapixel Whole Slide Images Foundation Model for Computational Pathologycited by 0
- 2026Decomposing Whole Slide Image Report Generation with Graph-Constrained Multiple Instance Learning Workflowscited by 0
- 2026SLICEChat: Progressive In-Encoder Token Pruning for Whole-Slide Pathology Language Modelscited by 0
- 2026SLICEChat: Progressive In-Encoder Token Pruning for Whole-Slide Pathology Language Models21 Sep 2026
- 2026Decomposing Whole Slide Image Report Generation with Graph-Constrained Multiple Instance Learning Workflows15 Aug 2026
- 2026From Multi-Resolution Cells to Gigapixel Whole Slide Images Foundation Model for Computational Pathology4 Aug 2026
- 2026Pathologist Attention-Aligned Report Generation for Prostate Histopathology21 Jul 2026
- 2026PathReportEval: A Systematic Benchmark for Pathology Report Generation20 Jul 2026
- 2026Auditing Data Leakage in Whole-Slide Image Multimodal Benchmarks14 Jul 2026
- 2026LaGuadia: Language-Guided Adaptive Distillation from Pathology Foundation Models13 Jul 2026
- 2026Prior-Anchored Debiasing for Long-Tailed Multi-Organ Pathology Report Generation1 Jul 2026
- 2026PathNavigate: A Training-Free Pathology Agent with Surprise-Guided Scan and Shared Slide Memory for Whole-Slide Image VQA22 May 2026
- 2026Semantic Context-aware mOdality fUsion Transformer (SCOUT): A Context-Aware Multimodal Transformer for Concept-Grounded Pathology Report Generation1 May 2026
- 2026PBSBench: A Multi-Level Vision-Language Framework and Benchmark for Hematopathology Whole Slide Image Interpretation19 Apr 2026
- 2026Layout-Guided Controllable Pathology Image Generation with In-Context Diffusion Transformers11 Mar 2026
19 more
- 2026PathMem: Toward Cognition-Aligned Memory Transformation for Pathology MLLMs10 Mar 2026
- 2026NuNext: Reframing Nucleus Detection as Next-Point Detection7 Mar 2026
- 2026RANGER: Sparsely-Gated Mixture-of-Experts with Adaptive Retrieval Re-ranking for Pathology Report Generation4 Mar 2026
- 2026Designing UNICORN: a Unified Benchmark for Imaging in Computational Pathology, Radiology, and Natural Language3 Mar 2026
- 2026QCAgent: An agentic framework for quality-controllable pathology report generation from whole slide image2 Mar 2026
- 2026Act Like a Pathologist: Tissue-Aware Whole Slide Image Reasoning28 Feb 2026
- 2026Footprint-Guided Exemplar-Free Continual Histopathology Report Generation27 Feb 2026
- 2026LAMMI-Pathology: A Tool-Centric Bottom-Up LVLM-Agent Framework for Molecularly Informed Medical Intelligence in Pathology21 Feb 2026
- 2026Multi-View Stenosis Classification Leveraging Transformer-Based Multiple-Instance Learning Using Real-World Clinical Data2 Feb 2026
- 2026PA-MIL: Phenotype-Aware Multiple Instance Learning Guided by Language Prompting and Genotype-to-Phenotype Relationships30 Jan 2026
- 2025Historical Report Guided Bi-modal Concurrent Learning for Pathology Report Generation23 Jun 2025
- 2025Any-to-Any Learning in Computational Pathology via Triplet Multimodal Pretraining19 May 2025
- 2025Content Generation Models in Computational Pathology: A Comprehensive Survey on Methods, Applications, and Challenges16 May 2025
- 2025CLIP-IT: CLIP-based Pairing for Histology Images Classification22 Apr 2025
- 2025PolyPath: Adapting a Large Multimodal Model for Multi-slide Pathology Report Generation14 Feb 2025
- 2024CPath-Omni: A Unified Multimodal Foundation Model for Patch and Whole Slide Image Analysis in Computational Pathology16 Dec 2024
- 2024WSI-LLaVA: A Multimodal Large Language Model for Whole Slide Image3 Dec 2024
- 2024Learning Spatial-Preserving Hierarchical Representations for Digital Pathology13 Jun 2024
- 2024HistGen: Histopathology Report Generation via Local-Global Feature Encoding and Cross-modal Context Interaction8 Mar 2024
- 2024WSI-LLaVA: A Multimodal Large Language Model for Whole Slide Imagecited by 40
- 2024CPath-Omni: A Unified Multimodal Foundation Model for Patch and Whole Slide Image Analysis in Computational Pathologycited by 34
- 2025PolyPath: Adapting a Large Multimodal Model for Multi-slide Pathology Report Generationcited by 4
- 2026Auditing Data Leakage in Whole-Slide Image Multimodal Benchmarkscited by 1
- 2026Footprint-Guided Exemplar-Free Continual Histopathology Report Generationcited by 0
- 2026SLICEChat: Progressive In-Encoder Token Pruning for Whole-Slide Pathology Language Modelscited by 0
- 2026SLICEChat: Progressive In-Encoder Token Pruning for Whole-Slide Pathology Language Models21 Sep 2026
- 2026Auditing Data Leakage in Whole-Slide Image Multimodal Benchmarks14 Jul 2026
- 2026Footprint-Guided Exemplar-Free Continual Histopathology Report Generation27 Feb 2026
- 2025PolyPath: Adapting a Large Multimodal Model for Multi-slide Pathology Report Generation14 Feb 2025
- 2024CPath-Omni: A Unified Multimodal Foundation Model for Patch and Whole Slide Image Analysis in Computational Pathology16 Dec 2024
- 2024WSI-LLaVA: A Multimodal Large Language Model for Whole Slide Image3 Dec 2024
- 2024HistGen: Histopathology Report Generation via Local-Global Feature Encoding and Cross-modal Context Interactioncited by 43
- 2025Historical Report Guided Bi-modal Concurrent Learning for Pathology Report Generationcited by 7
- 2026PathNavigate: A Training-Free Pathology Agent with Surprise-Guided Scan and Shared Slide Memory for Whole-Slide Image VQAcited by 7
- 2025Content Generation Models in Computational Pathology: A Comprehensive Survey on Methods, Applications, and Challengescited by 5
- 2026Designing UNICORN: a Unified Benchmark for Imaging in Computational Pathology, Radiology, and Natural Languagecited by 3
- 2026NuNext: Reframing Nucleus Detection as Next-Point Detectioncited by 2
- 2024Learning Spatial-Preserving Hierarchical Representations for Digital Pathologycited by 1
- 2025CLIP-IT: CLIP-based Pairing for Histology Images Classificationcited by 1
- 2026Multi-View Stenosis Classification Leveraging Transformer-Based Multiple-Instance Learning Using Real-World Clinical Datacited by 1
- 2026PathMem: Toward Cognition-Aligned Memory Transformation for Pathology MLLMscited by 1
- 2026Semantic Context-aware mOdality fUsion Transformer (SCOUT): A Context-Aware Multimodal Transformer for Concept-Grounded Pathology Report Generationcited by 1
- 2025Any-to-Any Learning in Computational Pathology via Triplet Multimodal Pretrainingcited by 0
12 most cited of 20 All 20 (JSON)
- 2026Decomposing Whole Slide Image Report Generation with Graph-Constrained Multiple Instance Learning Workflows15 Aug 2026
- 2026From Multi-Resolution Cells to Gigapixel Whole Slide Images Foundation Model for Computational Pathology4 Aug 2026
- 2026Pathologist Attention-Aligned Report Generation for Prostate Histopathology21 Jul 2026
- 2026PathReportEval: A Systematic Benchmark for Pathology Report Generation20 Jul 2026
- 2026LaGuadia: Language-Guided Adaptive Distillation from Pathology Foundation Models13 Jul 2026
- 2026Prior-Anchored Debiasing for Long-Tailed Multi-Organ Pathology Report Generation1 Jul 2026
- 2026PathNavigate: A Training-Free Pathology Agent with Surprise-Guided Scan and Shared Slide Memory for Whole-Slide Image VQA22 May 2026
- 2026Semantic Context-aware mOdality fUsion Transformer (SCOUT): A Context-Aware Multimodal Transformer for Concept-Grounded Pathology Report Generation1 May 2026
- 2026PBSBench: A Multi-Level Vision-Language Framework and Benchmark for Hematopathology Whole Slide Image Interpretation19 Apr 2026
- 2026PathMem: Toward Cognition-Aligned Memory Transformation for Pathology MLLMs10 Mar 2026
- 2026NuNext: Reframing Nucleus Detection as Next-Point Detection7 Mar 2026
- 2026Designing UNICORN: a Unified Benchmark for Imaging in Computational Pathology, Radiology, and Natural Language3 Mar 2026
12 newest of 20 All 20 (JSON)