Decoding Neuronal Networks: A Reservoir Computing Approach for Predicting Connectivity and Functionality

In this study, we address the challenge of analyzing electrophysiological measurements in neuronal networks. Our computational model, based on the Reservoir Computing Network (RCN) architecture, deciphers spatio-temporal data obtained from electrophysiological measurements of neuronal cultures. By reconstructing the network structure on a macroscopic scale, we reveal the connectivity between neuronal units. Notably, our model outperforms common methods like Cross-Correlation and Transfer-Entropy in predicting the network's connectivity map. Furthermore, we experimentally validate its ability to forecast network responses to specific inputs, including localized optogenetic stimuli.