Transfer Learning for Microstructure Segmentation with CS-UNet: A Hybrid Algorithm with Transformer and CNN Encoders

Transfer learning improves the performance of deep learning models by initializing them with parameters pre-trained on larger datasets. Intuitively, transfer learning is more effective when pre-training is on the in-domain datasets. A recent study by NASA has demonstrated that the microstructure segmentation with encoder-decoder algorithms benefits more from CNN encoders pre-trained on microscopy images than from those pre-trained on natural images. However, CNN models only capture the local spatial relations in images. In recent years, attention networks such as Transformers are increasingly used in image analysis to capture the long-range relations between pixels. In this study, we compare the segmentation performance of Transformer and CNN models pre-trained on microscopy images with those pre-trained on natural images. Our result partially confirms the NASA study that the segmentation performance of out-of-distribution images (taken under different imaging and sample conditions) is significantly improved when pre-training on microscopy images. However, the performance gain for one-shot and few-shot learning is more modest with Transformers. We also find that for image segmentation, the combination of pre-trained Transformers and CNN encoders are consistently better than pre-trained CNN encoders alone. Our dataset (of about 50,000 images) combines the public portion of the NASA dataset with additional images we collected. Even with much less training data, our pre-trained models have significantly better performance for image segmentation. This result suggests that Transformers and CNN complement each other and when pre-trained on microscopy images, they are more beneficial to the downstream tasks.