Deep Maxout Network-based Feature Fusion and Political Tangent Search Optimizer enabled Transfer Learning for Thalassemia Detection

Thalassemia is a heritable blood disorder which is the outcome of a genetic defect causing lack of production of hemoglobin polypeptide chains. However, there is less understanding of the precise frequency as well as sharing in these areas. Knowing about the frequency of thalassemia occurrence and dependable mutations is thus a significant step in preventing, controlling, and treatment planning. Here, Political Tangent Search Optimizer based Transfer Learning (PTSO_TL) is introduced for thalassemia detection. Initially, input data obtained from a particular dataset is normalized in the data normalization stage. Quantile normalization is utilized in the data normalization stage, and the data are then passed to the feature fusion phase, in which Weighted Euclidean Distance with Deep Maxout Network (DMN) is utilized. Thereafter, data augmentation is performed using the oversampling method to increase data dimensionality. Lastly, thalassemia detection is carried out by TL, wherein a convolutional neural network (CNN) is utilized with hyperparameters from a trained model such as Xception. TL is tuned by PTSO, and the training algorithm PTSO is presented by merging of Political Optimizer (PO) and Tangent Search Algorithm (TSA). Furthermore, PTSO_TL obtained maximal precision, recall, and f-measure values of about 94.3%, 96.1%, and 95.2%, respectively.