Efficient Generalization and Transportation

When estimating causal effects, it is important to assess external validity, i.e., determine how useful a given study is to inform a practical question for a specific target population. One challenge is that the covariate distribution in the population underlying a study may be different from that in the target population. If some covariates are effect modifiers, the average treatment effect (ATE) may not generalize to the target population. To tackle this problem, we propose new methods to generalize or transport the ATE from a source population to a target population, in the case where the source and target populations have different sets of covariates. When the ATE in the target population is identified, we propose new doubly robust estimators and establish their rates of convergence and limiting distributions. Under regularity conditions, the doubly robust estimators provably achieve the efficiency bound and are locally asymptotic minimax optimal. A sensitivity analysis is provided when the identification assumptions fail. Simulation studies show the advantages of the proposed doubly robust estimator over simple plug-in estimators. Importantly, we also provide minimax lower bounds and higher-order estimators of the target functionals. The proposed methods are applied in transporting causal effects of dietary intake on adverse pregnancy outcomes from an observational study to the whole U.S. pregnant female population.