mlsanityData to 7 Oct 2026

Data-Driven Disease Progression Modelling

arXiv 2211.05786 ↗First posted 1 Nov 2022q-bio.NC cs.LG q-bio.QMcited by 1

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Abstract (arXiv)

Intense debate in the Neurology community before 2010 culminated in hypothetical models of Alzheimer's disease progression: a pathophysiological cascade of biomarkers, each dynamic for only a segment of the full disease timeline. Inspired by this, data-driven disease progression modelling emerged from the computer science community with the aim to reconstruct neurodegenerative disease timelines using data from large cohorts of patients, healthy controls, and prodromal/at-risk individuals. This chapter describes selected highlights from the field, with a focus on utility for understanding and forecasting of disease progression.

Key facts. Cited by 1 paper in the map (data through 7 Oct 2026). Builds on 8 of its 60 references that are in the map. First posted on arXiv 1 Nov 2022.

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8 of 60 references.

References · 8

  1. 2021Clustering Interval-Censored Time-Series for Disease Phenotypingcited by 11
  2. 2019DIVE: A spatiotemporal progression model of brain pathology in neurodegenerative disorderscited by 6
  3. 2018Disease Progression Timeline Estimation for Alzheimer's Disease using Discriminative Event Based Modelingcited by 5
  4. 2021Ten years of image analysis and machine learning competitions in dementiacited by 5
  5. 2017A Discriminative Event Based Model for Alzheimer's Disease Progression Modelingcited by 3
  6. 2016A multivariate nonlinear mixed effects model for longitudinal image analysis: Application to amyloid imagingcited by 2
  7. 2017Bayesian latent time joint mixed effect models for multicohort longitudinal datacited by 2
  8. 2020Learning transition times in event sequences: the Event-Based Hidden Markov Model of disease progressioncited by 1

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