Toward Knowledge-Driven Speech-Based Models of Depression: Leveraging Spectrotemporal Variations in Speech Vowels

Psychomotor retardation associated with depression has been linked with tangible differences in vowel production. This paper investigates a knowledge-driven machine learning (ML) method that integrates spectrotemporal information of speech at the vowel-level to identify the depression. Low-level speech descriptors are learned by a convolutional neural network (CNN) that is trained for vowel classification. The temporal evolution of those low-level descriptors is modeled at the high-level within and across utterances via a long short-term memory (LSTM) model that takes the final depression decision. A modified version of the Local Interpretable Model-agnostic Explanations (LIME) is further used to identify the impact of the low-level spectrotemporal vowel variation on the decisions and observe the high-level temporal change of the depression likelihood. The proposed method outperforms baselines that model the spectrotemporal information in speech without integrating the vowel-based information, as well as ML models trained with conventional prosodic and spectrotemporal features. The conducted explainability analysis indicates that spectrotemporal information corresponding to non-vowel segments less important than the vowel-based information. Explainability of the high-level information capturing the segment-by-segment decisions is further inspected for participants with and without depression. The findings from this work can provide the foundation toward knowledge-driven interpretable decision-support systems that can assist clinicians to better understand fine-grain temporal changes in speech data, ultimately augmenting mental health diagnosis and care.