On the Effectiveness of Compact Biomedical Transformers
On the map: Knowledge distillation → Knowledge distillation for LLMs
Abstract (arXiv)
Language models pre-trained on biomedical corpora, such as BioBERT, have recently shown promising results on downstream biomedical tasks. Many existing pre-trained models, on the other hand, are resource-intensive and computationally heavy owing to factors such as embedding size, hidden dimension, and number of layers. The natural language processing (NLP) community has developed numerous strategies to compress these models utilising techniques such as pruning, quantisation, and knowledge distillation, resulting in models that are considerably faster, smaller, and subsequently easier to use in practice. By the same token, in this paper we introduce six lightweight models, namely, BioDistilBERT, BioTinyBERT, BioMobileBERT, DistilBioBERT, TinyBioBERT, and CompactBioBERT which are obtained either by knowledge distillation from a biomedical teacher or continual learning on the Pubmed dataset via the Masked Language Modelling (MLM) objective. We evaluate all of our models on three biomedical tasks and compare them with BioBERT-v1.1 to create efficient lightweight models that perform on par with their larger counterparts. All the models will be publicly available on our Huggingface profile at https://huggingface.co/nlpie and the codes used to run the experiments will be available at https://github.com/nlpie-research/Compact-Biomedical-Transformers.
Key facts. Cited by 11 papers in the map (data through 14 Oct 2026). Placed in Knowledge distillation for LLMs, one of 12 directions in Knowledge distillation. Builds on 31 of its 50 references that are in the map. First posted on arXiv 7 Sep 2022.
Builds on
31 of 50 references.
References · 31
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19 more
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Built on by
Citing papers per year: 2022: 1; 2023: 4; 2024: 4; 2025: 2.
11 papers.
- 2023Exploring the Effectiveness of Instruction Tuning in Biomedical Language Processingcited by 16
- 2023Lightweight Transformers for Clinical Natural Language Processingcited by 15
- 2024PromptLink: Leveraging Large Language Models for Cross-Source Biomedical Concept Linkingcited by 15
- 2022MiniALBERT: Model Distillation via Parameter-Efficient Recursive Transformerscited by 5
- 2024Efficiency at Scale: Investigating the Performance of Diminutive Language Models in Clinical Taskscited by 4
- 2025Investigating Task Arithmetic for Zero-Shot Information Retrievalcited by 4
- 2024VANER: Leveraging Large Language Model for Versatile and Adaptive Biomedical Named Entity Recognitioncited by 2
- 2023Privacy Aware Question-Answering System for Online Mental Health Risk Assessmentcited by 1
- 2025Towards Scalable and Cross-Lingual Specialist Language Models for Oncologycited by 1
- 2023Iteratively Improving Biomedical Entity Linking and Event Extraction via Hard Expectation-Maximizationcited by 0
- 2024Boosting Biomedical Concept Extraction by Rule-Based Data Augmentationcited by 0
- 2025Investigating Task Arithmetic for Zero-Shot Information Retrieval1 May 2025
- 2025Towards Scalable and Cross-Lingual Specialist Language Models for Oncology11 Mar 2025
- 2024Boosting Biomedical Concept Extraction by Rule-Based Data Augmentation3 Jul 2024
- 2024PromptLink: Leveraging Large Language Models for Cross-Source Biomedical Concept Linking13 May 2024
- 2024VANER: Leveraging Large Language Model for Versatile and Adaptive Biomedical Named Entity Recognition27 Apr 2024
- 2024Efficiency at Scale: Investigating the Performance of Diminutive Language Models in Clinical Tasks16 Feb 2024
- 2023Exploring the Effectiveness of Instruction Tuning in Biomedical Language Processing31 Dec 2023
- 2023Privacy Aware Question-Answering System for Online Mental Health Risk Assessment9 Jun 2023
- 2023Iteratively Improving Biomedical Entity Linking and Event Extraction via Hard Expectation-Maximization24 May 2023
- 2023Lightweight Transformers for Clinical Natural Language Processing9 Feb 2023
- 2022MiniALBERT: Model Distillation via Parameter-Efficient Recursive Transformers12 Oct 2022
Similar, not cited
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- 2023Benchmarking large language models for biomedical natural language processing applications and recommendations
- 2024A Survey for Large Language Models in Biomedicine
- 2024Biomedical Large Languages Models Seem not to be Superior to Generalist Models on Unseen Medical Data
- 2023BioLORD-2023: Semantic Textual Representations Fusing LLM and Clinical Knowledge Graph Insights
- 2025Quantized Large Language Models in Biomedical Natural Language Processing: Evaluation and Recommendation
- 2024BioMistral: A Collection of Open-Source Pretrained Large Language Models for Medical Domains
- 2024BioMamba: Domain-Adaptive Biomedical Language Models
- 2026Investigating Model Compression for Neural Machine Translation in the Biomedical Domain