Learning Apparent Diffusion Coefficient Maps from Accelerated Radial k-Space Diffusion-Weighted MRI in Mice using a Deep CNN-Transformer Model

Purpose: To accelerate radially sampled diffusion weighted spin-echo (Rad-DW-SE) acquisition method for generating high quality apparent diffusion coefficient (ADC) maps. Methods: A deep learning method was developed to generate accurate ADC maps from accelerated DWI data acquired with the Rad-DW-SE method. The deep learning method integrates convolutional neural networks (CNNs) with vision transformers to generate high quality ADC maps from accelerated DWI data, regularized by a monoexponential ADC model fitting term. A model was trained on DWI data of 147 mice and evaluated on DWI data of 36 mice, with acceleration factors of 4x and 8x compared to the original acquisition parameters. We have made our code publicly available at GitHub: https://github.com/ymli39/DeepADC-Net-Learning-Apparent-Diffusion-Coefficient-Maps, and our dataset can be downloaded at https://pennpancreaticcancerimagingresource.github.io/data.html. Results: Ablation studies and experimental results have demonstrated that the proposed deep learning model generates higher quality ADC maps from accelerated DWI data than alternative deep learning methods under comparison when their performance is quantified in whole images as well as in regions of interest, including tumors, kidneys, and muscles. Conclusions: The deep learning method with integrated CNNs and transformers provides an effective means to accurately compute ADC maps from accelerated DWI data acquired with the Rad-DW-SE method.