Does prior knowledge in the form of multiple low-dose PET images (at different dose levels) improve standard-dose PET prediction?

Reducing the injected dose would result in quality degradation and loss of information in PET imaging. To address this issue, deep learning methods have been introduced to predict standard PET images (S-PET) from the corresponding low-dose versions (L-PET). The existing deep learning-based denoising methods solely rely on a single dose level of PET images to predict the S-PET images. In this work, we proposed to exploit the prior knowledge in the form of multiple low-dose levels of PET images (in addition to the target low-dose level) to estimate the S-PET images.