ICON: Learning Regular Maps Through Inverse Consistency
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Abstract (arXiv)
Learning maps between data samples is fundamental. Applications range from representation learning, image translation and generative modeling, to the estimation of spatial deformations. Such maps relate feature vectors, or map between feature spaces. Well-behaved maps should be regular, which can be imposed explicitly or may emanate from the data itself. We explore what induces regularity for spatial transformations, e.g., when computing image registrations. Classical optimization-based models compute maps between pairs of samples and rely on an appropriate regularizer for well-posedness. Recent deep learning approaches have attempted to avoid using such regularizers altogether by relying on the sample population instead. We explore if it is possible to obtain spatial regularity using an inverse consistency loss only and elucidate what explains map regularity in such a context. We find that deep networks combined with an inverse consistency loss and randomized off-grid interpolation yield well behaved, approximately diffeomorphic, spatial transformations. Despite the simplicity of this approach, our experiments present compelling evidence, on both synthetic and real data, that regular maps can be obtained without carefully tuned explicit regularizers, while achieving competitive registration performance.
Key facts. Cited by 26 papers in the map (data through 7 Oct 2026). Builds on 24 of its 47 references that are in the map. First posted on arXiv 10 May 2021.
Builds on
24 of 47 references.
References · 24
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12 more
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Citing papers per year: 2021: 1; 2022: 1; 2023: 7; 2024: 5; 2025: 8; 2026: 4.
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- 2023A survey on deep learning in medical image registration: new technologies, uncertainty, evaluation metrics, and beyondcited by 55
- 2024uniGradICON: A Foundation Model for Medical Image Registrationcited by 55
- 2022textttGradICON: Approximate Diffeomorphisms via Gradient Inverse Consistencycited by 40
- 2021NODEO: A Neural Ordinary Differential Equation Based Optimization Framework for Deformable Image Registrationcited by 28
- 2024multiGradICON: A Foundation Model for Multimodal Medical Image Registrationcited by 16
- 2023Inverse Consistency by Construction for Multistep Deep Registrationcited by 12
- 2023SAME++: A Self-supervised Anatomical eMbeddings Enhanced medical image registration framework using stable sampling and regularized transformationcited by 9
- 2023textttNePhi: Neural Deformation Fields for Approximately Diffeomorphic Medical Image Registrationcited by 8
- 2023NAISR: A 3D Neural Additive Model for Interpretable Shape Representationcited by 7
- 2025Improving Generalization of Medical Image Registration Foundation Modelcited by 6
- 2025Guiding Registration with Emergent Similarity from Pre-Trained Diffusion Modelscited by 6
- 2023Exploring Cycle Consistency Learning in Interactive Volume Segmentationcited by 4
14 more
- 2025Disentangling Progress in Medical Image Registration: Beyond Trend-Driven Architectures towards Domain-Specific Strategiescited by 4
- 2023Towards Saner Deep Image Registrationcited by 3
- 2024Gaussian Primitives for Deformable Image Registrationcited by 2
- 2024CARL: A Framework for Equivariant Image Registrationcited by 1
- 2024LEDA: Log-Euclidean Diffeomorphism Autoencoder for Efficient Statistical Analysis of Diffeomorphismscited by 1
- 2025Mono-Modalizing Extremely Heterogeneous Multi-Modal Medical Image Registrationcited by 1
- 2025Uncertainty Estimation for Pretrained Medical Image Registration Models via Transformation Equivariancecited by 1
- 2026Characterizing and Optimizing the Spatial Kernel of Multi Resolution Hash Encodingscited by 1
- 2026Geometric regularization of autoencoders via observed stochastic dynamicscited by 1
- 2025Biomechanical Constraints Assimilation in Deep-Learning Image Registration: Application to sliding and locally rigid deformationscited by 0
- 2025Deformable Medical Image Registration with KAN-based Implicit Neural Representationscited by 0
- 2025Multimodal Diffeomorphic Registration with Neural ODEs and Structural Descriptorscited by 0
- 2026PRISM: A 3D Probabilistic Neural Representation for Interpretable Shape Modelingcited by 0
- 2026Robotic Ultrasound Makes CBCT Alivecited by 0
- 2026Geometric regularization of autoencoders via observed stochastic dynamics17 Apr 2026
- 2026Robotic Ultrasound Makes CBCT Alive10 Mar 2026
- 2026PRISM: A 3D Probabilistic Neural Representation for Interpretable Shape Modeling12 Feb 2026
- 2026Characterizing and Optimizing the Spatial Kernel of Multi Resolution Hash Encodings11 Feb 2026
- 2025Multimodal Diffeomorphic Registration with Neural ODEs and Structural Descriptors27 Dec 2025
- 2025Disentangling Progress in Medical Image Registration: Beyond Trend-Driven Architectures towards Domain-Specific Strategies1 Dec 2025
- 2025Uncertainty Estimation for Pretrained Medical Image Registration Models via Transformation Equivariance27 Sep 2025
- 2025Deformable Medical Image Registration with KAN-based Implicit Neural Representations26 Sep 2025
- 2025Mono-Modalizing Extremely Heterogeneous Multi-Modal Medical Image Registration18 Jun 2025
- 2025Guiding Registration with Emergent Similarity from Pre-Trained Diffusion Models3 Jun 2025
- 2025Improving Generalization of Medical Image Registration Foundation Model10 May 2025
- 2025Biomechanical Constraints Assimilation in Deep-Learning Image Registration: Application to sliding and locally rigid deformations7 Apr 2025
14 more
- 2024LEDA: Log-Euclidean Diffeomorphism Autoencoder for Efficient Statistical Analysis of Diffeomorphisms20 Dec 2024
- 2024multiGradICON: A Foundation Model for Multimodal Medical Image Registration1 Aug 2024
- 2024Gaussian Primitives for Deformable Image Registration5 Jun 2024
- 2024CARL: A Framework for Equivariant Image Registration27 May 2024
- 2024uniGradICON: A Foundation Model for Medical Image Registration9 Mar 2024
- 2023SAME++: A Self-supervised Anatomical eMbeddings Enhanced medical image registration framework using stable sampling and regularized transformation25 Nov 2023
- 2023textttNePhi: Neural Deformation Fields for Approximately Diffeomorphic Medical Image Registration13 Sep 2023
- 2023A survey on deep learning in medical image registration: new technologies, uncertainty, evaluation metrics, and beyond28 Jul 2023
- 2023Towards Saner Deep Image Registration19 Jul 2023
- 2023Inverse Consistency by Construction for Multistep Deep Registration28 Apr 2023
- 2023NAISR: A 3D Neural Additive Model for Interpretable Shape Representation16 Mar 2023
- 2023Exploring Cycle Consistency Learning in Interactive Volume Segmentation11 Mar 2023
- 2022textttGradICON: Approximate Diffeomorphisms via Gradient Inverse Consistency13 Jun 2022
- 2021NODEO: A Neural Ordinary Differential Equation Based Optimization Framework for Deformable Image Registration7 Aug 2021
- 2023A survey on deep learning in medical image registration: new technologies, uncertainty, evaluation metrics, and beyondcited by 55
- 2024uniGradICON: A Foundation Model for Medical Image Registrationcited by 55
- 2022textttGradICON: Approximate Diffeomorphisms via Gradient Inverse Consistencycited by 40
- 2021NODEO: A Neural Ordinary Differential Equation Based Optimization Framework for Deformable Image Registrationcited by 28
- 2024multiGradICON: A Foundation Model for Multimodal Medical Image Registrationcited by 16
- 2023Inverse Consistency by Construction for Multistep Deep Registrationcited by 12
- 2023SAME++: A Self-supervised Anatomical eMbeddings Enhanced medical image registration framework using stable sampling and regularized transformationcited by 9
- 2023textttNePhi: Neural Deformation Fields for Approximately Diffeomorphic Medical Image Registrationcited by 8
- 2023NAISR: A 3D Neural Additive Model for Interpretable Shape Representationcited by 7
- 2025Improving Generalization of Medical Image Registration Foundation Modelcited by 6
- 2023Exploring Cycle Consistency Learning in Interactive Volume Segmentationcited by 4
- 2025Disentangling Progress in Medical Image Registration: Beyond Trend-Driven Architectures towards Domain-Specific Strategiescited by 4
12 most cited of 25 All 25 (JSON)
- 2026Geometric regularization of autoencoders via observed stochastic dynamics17 Apr 2026
- 2026Robotic Ultrasound Makes CBCT Alive10 Mar 2026
- 2026PRISM: A 3D Probabilistic Neural Representation for Interpretable Shape Modeling12 Feb 2026
- 2026Characterizing and Optimizing the Spatial Kernel of Multi Resolution Hash Encodings11 Feb 2026
- 2025Multimodal Diffeomorphic Registration with Neural ODEs and Structural Descriptors27 Dec 2025
- 2025Disentangling Progress in Medical Image Registration: Beyond Trend-Driven Architectures towards Domain-Specific Strategies1 Dec 2025
- 2025Uncertainty Estimation for Pretrained Medical Image Registration Models via Transformation Equivariance27 Sep 2025
- 2025Deformable Medical Image Registration with KAN-based Implicit Neural Representations26 Sep 2025
- 2025Mono-Modalizing Extremely Heterogeneous Multi-Modal Medical Image Registration18 Jun 2025
- 2025Improving Generalization of Medical Image Registration Foundation Model10 May 2025
- 2025Biomechanical Constraints Assimilation in Deep-Learning Image Registration: Application to sliding and locally rigid deformations7 Apr 2025
- 2024LEDA: Log-Euclidean Diffeomorphism Autoencoder for Efficient Statistical Analysis of Diffeomorphisms20 Dec 2024
12 newest of 25 All 25 (JSON)