Reliable Tuberculosis Detection using Chest X-ray with Deep Learning, Segmentation and Visualization
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Abstract (arXiv)
Tuberculosis (TB) is a chronic lung disease that occurs due to bacterial infection and is one of the top 10 leading causes of death. Accurate and early detection of TB is very important, otherwise, it could be life-threatening. In this work, we have detected TB reliably from the chest X-ray images using image pre-processing, data augmentation, image segmentation, and deep-learning classification techniques. Several public databases were used to create a database of 700 TB infected and 3500 normal chest X-ray images for this study. Nine different deep CNNs (ResNet18, ResNet50, ResNet101, ChexNet, InceptionV3, Vgg19, DenseNet201, SqueezeNet, and MobileNet), which were used for transfer learning from their pre-trained initial weights and trained, validated and tested for classifying TB and non-TB normal cases. Three different experiments were carried out in this work: segmentation of X-ray images using two different U-net models, classification using X-ray images, and segmented lung images. The accuracy, precision, sensitivity, F1-score, specificity in the detection of tuberculosis using X-ray images were 97.07 %, 97.34 %, 97.07 %, 97.14 % and 97.36 % respectively. However, segmented lungs for the classification outperformed than whole X-ray image-based classification and accuracy, precision, sensitivity, F1-score, specificity were 99.9 %, 99.91 %, 99.9 %, 99.9 %, and 99.52 % respectively. The paper also used a visualization technique to confirm that CNN learns dominantly from the segmented lung regions results in higher detection accuracy. The proposed method with state-of-the-art performance can be useful in the computer-aided faster diagnosis of tuberculosis.
Key facts. Cited by 50 papers in the map (data through 7 Oct 2026). First posted on arXiv 29 Jul 2020.
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Citing papers per year: 2021: 5; 2022: 7; 2023: 7; 2024: 12; 2025: 15; 2026: 4.
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- 2021COVID-19 Infection Localization and Severity Grading from Chest X-ray Imagescited by 46
- 2022Improving deep neural network generalization and robustness to background bias via layer-wise relevance propagation optimizationcited by 25
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- 2022Recent Progress in Transformer-based Medical Image Analysiscited by 9
- 2021TB-Net: A Tailored, Self-Attention Deep Convolutional Neural Network Design for Detection of Tuberculosis Cases from Chest X-ray Imagescited by 8
- 2022An Accurate and Explainable Deep Learning System Improves Interobserver Agreement in the Interpretation of Chest Radiographcited by 7
- 2025RepViT-CXR: A Channel Replication Strategy for Vision Transformers in Chest X-ray Tuberculosis and Pneumonia Classificationcited by 7
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- 2021Class dependency based learning using Bi-LSTM coupled with the transfer learning of VGG16 for the diagnosis of Tuberculosis from chest x-rayscited by 1
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- 2026Exponential Pixelating Integral transform with dual fractal features for enhanced chest X-ray abnormality detection10 Sep 2026
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- 2026Intelligent Documentation in Medical Education: Can AI Replace Manual Case Logging?19 Jan 2026
- 2025CLARiTy: A Vision Transformer for Multi-Label Classification and Weakly-Supervised Localization of Chest X-ray Pathologies18 Dec 2025
- 2025Weakly Supervised Concept Learning with Class-Level Priors for Interpretable Medical Diagnosis3 Nov 2025
- 2025An Explainable Hybrid AI Framework for Enhanced Tuberculosis and Symptom Detection21 Oct 2025
- 2025Incentive-Based Federated Learning: Architectural Elements and Future Directions16 Oct 2025
- 2025RepViT-CXR: A Channel Replication Strategy for Vision Transformers in Chest X-ray Tuberculosis and Pneumonia Classification10 Sep 2025
- 2025FedMP: Tackling Medical Feature Heterogeneity in Federated Learning from a Manifold Perspective7 Aug 2025
- 2025VGS-ATD: Robust Distributed Learning for Multi-Label Medical Image Classification Under Heterogeneous and Imbalanced Conditions23 Jul 2025
- 2025Explainable Artificial Intelligence in Biomedical Image Analysis: A Comprehensive Survey9 Jul 2025
38 more
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- 2025MedPrompt: LLM-CNN Fusion with Weight Routing for Medical Image Segmentation and Classification26 Jun 2025
- 2025Novel Pooling-based VGG-Lite for Pneumonia and Covid-19 Detection from Imbalanced Chest X-Ray Datasets10 Apr 2025
- 2025Federated Learning for Medical Image Classification: A Comprehensive Benchmark7 Apr 2025
- 2025Interpretable Deep Learning Framework for Improved Disease Classification in Medical Imaging14 Mar 2025
- 2025Pulmonary Tuberculosis Edge Diagnosis System Based on MindSpore Framework: Low-cost and High-precision Implementation with Ascend 310 Chip15 Feb 2025
- 2025Self-CephaloNet: A Two-stage Novel Framework using Operational Neural Network for Cephalometric Analysis19 Jan 2025
- 2024Reconciling Privacy and Explainability in High-Stakes: A Systematic Inquiry30 Dec 2024
- 2024Exploring Compositional Generalization of Multimodal LLMs for Medical Imaging28 Dec 2024
- 2024Self-DenseMobileNet: A Robust Framework for Lung Nodule Classification using Self-ONN and Stacking-based Meta-Classifier16 Oct 2024
- 2024A foundation model for generalizable disease diagnosis in chest X-ray images11 Oct 2024
- 2024Few-Shot Learning Approach on Tuberculosis Classification Based on Chest X-Ray Images18 Sep 2024
- 2024HYDEN: Hyperbolic Density Representations for Medical Images and Reports19 Aug 2024
- 2024Empowering Tuberculosis Screening with Explainable Self-Supervised Deep Neural Networks19 Jun 2024
- 2024Explore the Limits of Omni-modal Pretraining at Scale13 Jun 2024
- 2024Redefining Contributions: Shapley-Driven Federated Learning1 Jun 2024
- 2024Hierarchical SegNet with Channel and Context Attention for Accurate Lung Segmentation in Chest X-ray Images20 May 2024
- 2024A Novel Approach to Chest X-ray Lung Segmentation Using U-net and Modified Convolutional Block Attention Module22 Apr 2024
- 2024INSITE: labelling medical images using submodular functions and semi-supervised data programming11 Feb 2024
- 2023How much data do I need? A case study on medical data26 Nov 2023
- 2023Deep learning in computed tomography pulmonary angiography imaging: a dual-pronged approach for pulmonary embolism detection9 Nov 2023
- 2023Improving Robustness and Reliability in Medical Image Classification with Latent-Guided Diffusion and Nested-Ensembles24 Oct 2023
- 2023SEDA: Self-Ensembling ViT with Defensive Distillation and Adversarial Training for robust Chest X-rays Classification15 Aug 2023
- 2023Meta-Transformer: A Unified Framework for Multimodal Learning20 Jul 2023
- 2023On enhancing the robustness of Vision Transformers: Defensive Diffusion14 May 2023
- 2023Vision Transformer for Efficient Chest X-ray and Gastrointestinal Image Classification23 Apr 2023
- 2022NEVIS'22: A Stream of 100 Tasks Sampled from 30 Years of Computer Vision Research15 Nov 2022
- 2022Recent Progress in Transformer-based Medical Image Analysis13 Aug 2022
- 2022An Accurate and Explainable Deep Learning System Improves Interobserver Agreement in the Interpretation of Chest Radiograph6 Aug 2022
- 2022Self-Ensembling Vision Transformer (SEViT) for Robust Medical Image Classification4 Aug 2022
- 2022BIO-CXRNET: A Robust Multimodal Stacking Machine Learning Technique for Mortality Risk Prediction of COVID-19 Patients using Chest X-Ray Images and Clinical Data15 Jun 2022
- 2022Improving deep neural network generalization and robustness to background bias via layer-wise relevance propagation optimization1 Feb 2022
- 2022RamanNet: A generalized neural network architecture for Raman Spectrum Analysis20 Jan 2022
- 2021Class dependency based learning using Bi-LSTM coupled with the transfer learning of VGG16 for the diagnosis of Tuberculosis from chest x-rays19 Jul 2021
- 2021A Machine Learning Model for Early Detection of Diabetic Foot using Thermogram Images27 Jun 2021
- 2021COV-ECGNET: COVID-19 detection using ECG trace images with deep convolutional neural network1 Jun 2021
- 2021TB-Net: A Tailored, Self-Attention Deep Convolutional Neural Network Design for Detection of Tuberculosis Cases from Chest X-ray Images6 Apr 2021
- 2021COVID-19 Infection Localization and Severity Grading from Chest X-ray Images14 Mar 2021
- 2023Meta-Transformer: A Unified Framework for Multimodal Learningcited by 136
- 2021COVID-19 Infection Localization and Severity Grading from Chest X-ray Imagescited by 46
- 2022Improving deep neural network generalization and robustness to background bias via layer-wise relevance propagation optimizationcited by 25
- 2022NEVIS'22: A Stream of 100 Tasks Sampled from 30 Years of Computer Vision Researchcited by 18
- 2022Self-Ensembling Vision Transformer (SEViT) for Robust Medical Image Classificationcited by 16
- 2024Redefining Contributions: Shapley-Driven Federated Learningcited by 16
- 2025OmniVec2 -- A Novel Transformer based Network for Large Scale Multimodal and Multitask Learningcited by 13
- 2024A foundation model for generalizable disease diagnosis in chest X-ray imagescited by 12
- 2022Recent Progress in Transformer-based Medical Image Analysiscited by 9
- 2021TB-Net: A Tailored, Self-Attention Deep Convolutional Neural Network Design for Detection of Tuberculosis Cases from Chest X-ray Imagescited by 8
- 2022An Accurate and Explainable Deep Learning System Improves Interobserver Agreement in the Interpretation of Chest Radiographcited by 7
- 2025RepViT-CXR: A Channel Replication Strategy for Vision Transformers in Chest X-ray Tuberculosis and Pneumonia Classificationcited by 7
12 most cited of 47 All 47 (JSON)
- 2026Exponential Pixelating Integral transform with dual fractal features for enhanced chest X-ray abnormality detection10 Sep 2026
- 2026SecondOpinion: Anatomy-Aware Gated Reasoning for Efficient Medical Image Analysis3 Aug 2026
- 2026HyPCA-Net: Advancing Multimodal Fusion in Medical Image Analysis18 Feb 2026
- 2026Intelligent Documentation in Medical Education: Can AI Replace Manual Case Logging?19 Jan 2026
- 2025CLARiTy: A Vision Transformer for Multi-Label Classification and Weakly-Supervised Localization of Chest X-ray Pathologies18 Dec 2025
- 2025Weakly Supervised Concept Learning with Class-Level Priors for Interpretable Medical Diagnosis3 Nov 2025
- 2025An Explainable Hybrid AI Framework for Enhanced Tuberculosis and Symptom Detection21 Oct 2025
- 2025Incentive-Based Federated Learning: Architectural Elements and Future Directions16 Oct 2025
- 2025RepViT-CXR: A Channel Replication Strategy for Vision Transformers in Chest X-ray Tuberculosis and Pneumonia Classification10 Sep 2025
- 2025FedMP: Tackling Medical Feature Heterogeneity in Federated Learning from a Manifold Perspective7 Aug 2025
- 2025VGS-ATD: Robust Distributed Learning for Multi-Label Medical Image Classification Under Heterogeneous and Imbalanced Conditions23 Jul 2025
- 2025Explainable Artificial Intelligence in Biomedical Image Analysis: A Comprehensive Survey9 Jul 2025
12 newest of 47 All 47 (JSON)