A Comprehensive Analysis of Weakly-Supervised Semantic Segmentation in Different Image Domains
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Abstract (arXiv)
Recently proposed methods for weakly-supervised semantic segmentation have achieved impressive performance in predicting pixel classes despite being trained with only image labels which lack positional information. Because image annotations are cheaper and quicker to generate, weak supervision is more practical than full supervision for training segmentation algorithms. These methods have been predominantly developed to solve the background separation and partial segmentation problems presented by natural scene images and it is unclear whether they can be simply transferred to other domains with different characteristics, such as histopathology and satellite images, and still perform well. This paper evaluates state-of-the-art weakly-supervised semantic segmentation methods on natural scene, histopathology, and satellite image datasets and analyzes how to determine which method is most suitable for a given dataset. Our experiments indicate that histopathology and satellite images present a different set of problems for weakly-supervised semantic segmentation than natural scene images, such as ambiguous boundaries and class co-occurrence. Methods perform well for datasets they were developed on, but tend to perform poorly on other datasets. We present some practical techniques for these methods on unseen datasets and argue that more work is needed for a generalizable approach to weakly-supervised semantic segmentation. Our full code implementation is available on GitHub: https://github.com/lyndonchan/wsss-analysis.
Key facts. Cited by 33 papers in the map (data through 7 Oct 2026). First posted on arXiv 24 Dec 2019.
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Citing papers per year: 2021: 7; 2022: 10; 2023: 7; 2024: 2; 2025: 6; 2026: 1.
33 papers.
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- 2022Deep Spectral Methods: A Surprisingly Strong Baseline for Unsupervised Semantic Segmentation and Localizationcited by 150
- 2023Towards Generic Image Manipulation Detection with Weakly-Supervised Self-Consistency Learningcited by 23
- 2021Learning Whole-Slide Segmentation from Inexact and Incomplete Labels using Tissue Graphscited by 22
- 2022Pointly-Supervised Panoptic Segmentationcited by 20
- 2023Weakly-Supervised Semantic Segmentation with Image-Level Labels: from Traditional Models to Foundation Modelscited by 19
- 2023Background Activation Suppression for Weakly Supervised Object Localization and Semantic Segmentationcited by 17
- 2023Weakly Supervised Joint Whole-Slide Segmentation and Classification in Prostate Cancercited by 10
- 2021WeGleNet: A Weakly-Supervised Convolutional Neural Network for the Semantic Segmentation of Gleason Grades in Prostate Histology Imagescited by 9
- 2023AME-CAM: Attentive Multiple-Exit CAM for Weakly Supervised Segmentation on MRI Brain Tumorcited by 8
- 2025WeakMedSAM: Weakly-Supervised Medical Image Segmentation via SAM with Sub-Class Exploration and Prompt Affinity Miningcited by 8
- 2021A Novel Graph-Theoretic Deep Representation Learning Method for Multi-Label Remote Sensing Image Retrievalcited by 7
- 2022Mixed-UNet: Refined Class Activation Mapping for Weakly-Supervised Semantic Segmentation with Multi-scale Inferencecited by 7
21 more
- 2024Upsampling DINOv2 features for unsupervised vision tasks and weakly supervised materials segmentationcited by 6
- 2022Weakly Supervised Semantic Segmentation of Remote Sensing Images for Tree Species Classification Based on Explanation Methodscited by 5
- 2023Learning Neural Eigenfunctions for Unsupervised Semantic Segmentationcited by 4
- 2021Rethinking Lightweight Convolutional Neural Networks for Efficient and High-quality Pavement Crack Detectioncited by 3
- 2021CheXseg: Combining Expert Annotations with DNN-generated Saliency Maps for X-ray Segmentationcited by 2
- 2022Learning to segment prostate cancer by aggressiveness from scribbles in bi-parametric MRIcited by 2
- 2022ISIM: Iterative Self-Improved Model for Weakly Supervised Segmentationcited by 2
- 2025Superpixel Boundary Correction for Weakly-Supervised Semantic Segmentation on Histopathology Imagescited by 2
- 2021Weakly-Supervised Cloud Detection with Fixed-Point GANscited by 1
- 2022Experimental Large-Scale Jet Flames' Geometrical Features Extraction for Risk Management Using Infrared Images and Deep Learning Segmentation Methodscited by 1
- 2022Weakly Supervised Deep Instance Nuclei Detection using Points Annotation in 3D Cardiovascular Immunofluorescent Imagescited by 1
- 2023Weakly supervised segmentation of intracranial aneurysms using a novel 3D focal modulation UNetcited by 1
- 2025A drone-based framework for coral habitat mapping via weakly supervised segmentationcited by 1
- 2021Expectation-Maximization Regularized Deep Learning for Weakly Supervised Tumor Segmentation for Glioblastomacited by 0
- 2022Semantic Segmentation of Anaemic RBCs Using Multilevel Deep Convolutional Encoder-Decoder Networkcited by 0
- 2022Learning with Weak Annotations for Robust Maritime Obstacle Detectioncited by 0
- 2024Enhancing Weakly Supervised Semantic Segmentation for Fibrosis via Controllable Image Generationcited by 0
- 2025Opening the black box of deep learning: Validating the statistical association between explainable artificial intelligence (XAI) and clinical domain knowledge in fundus image-based glaucoma diagnosiscited by 0
- 2025Depth Edge Alignment Loss: DEALing with Depth in Weakly Supervised Semantic Segmentationcited by 0
- 2025A deep multiple instance learning approach based on coarse labels for high-resolution land-cover mappingcited by 0
- 2026Semantic Segmentation for Histopathology using Learned Regularization based on Global Proportionscited by 0
- 2026Semantic Segmentation for Histopathology using Learned Regularization based on Global Proportions27 Apr 2026
- 2025A deep multiple instance learning approach based on coarse labels for high-resolution land-cover mapping8 Oct 2025
- 2025Depth Edge Alignment Loss: DEALing with Depth in Weakly Supervised Semantic Segmentation22 Sep 2025
- 2025A drone-based framework for coral habitat mapping via weakly supervised segmentation26 Aug 2025
- 2025Opening the black box of deep learning: Validating the statistical association between explainable artificial intelligence (XAI) and clinical domain knowledge in fundus image-based glaucoma diagnosis6 Apr 2025
- 2025WeakMedSAM: Weakly-Supervised Medical Image Segmentation via SAM with Sub-Class Exploration and Prompt Affinity Mining6 Mar 2025
- 2025Superpixel Boundary Correction for Weakly-Supervised Semantic Segmentation on Histopathology Images7 Jan 2025
- 2024Enhancing Weakly Supervised Semantic Segmentation for Fibrosis via Controllable Image Generation5 Nov 2024
- 2024Upsampling DINOv2 features for unsupervised vision tasks and weakly supervised materials segmentation20 Oct 2024
- 2023Weakly-Supervised Semantic Segmentation with Image-Level Labels: from Traditional Models to Foundation Models19 Oct 2023
- 2023Background Activation Suppression for Weakly Supervised Object Localization and Semantic Segmentation22 Sep 2023
- 2023Towards Generic Image Manipulation Detection with Weakly-Supervised Self-Consistency Learning3 Sep 2023
21 more
- 2023Weakly supervised segmentation of intracranial aneurysms using a novel 3D focal modulation UNet6 Aug 2023
- 2023AME-CAM: Attentive Multiple-Exit CAM for Weakly Supervised Segmentation on MRI Brain Tumor26 Jun 2023
- 2023Learning Neural Eigenfunctions for Unsupervised Semantic Segmentation6 Apr 2023
- 2023Weakly Supervised Joint Whole-Slide Segmentation and Classification in Prostate Cancer7 Jan 2023
- 2022ISIM: Iterative Self-Improved Model for Weakly Supervised Segmentation22 Nov 2022
- 2022Pointly-Supervised Panoptic Segmentation25 Oct 2022
- 2022Weakly Supervised Deep Instance Nuclei Detection using Points Annotation in 3D Cardiovascular Immunofluorescent Images29 Jul 2022
- 2022Learning to segment prostate cancer by aggressiveness from scribbles in bi-parametric MRI1 Jul 2022
- 2022Learning with Weak Annotations for Robust Maritime Obstacle Detection27 Jun 2022
- 2022Deep Spectral Methods: A Surprisingly Strong Baseline for Unsupervised Semantic Segmentation and Localization16 May 2022
- 2022Mixed-UNet: Refined Class Activation Mapping for Weakly-Supervised Semantic Segmentation with Multi-scale Inference6 May 2022
- 2022Semantic Segmentation of Anaemic RBCs Using Multilevel Deep Convolutional Encoder-Decoder Network9 Feb 2022
- 2022Experimental Large-Scale Jet Flames' Geometrical Features Extraction for Risk Management Using Infrared Images and Deep Learning Segmentation Methods20 Jan 2022
- 2022Weakly Supervised Semantic Segmentation of Remote Sensing Images for Tree Species Classification Based on Explanation Methods19 Jan 2022
- 2021Weakly-Supervised Cloud Detection with Fixed-Point GANs23 Nov 2021
- 2021Rethinking Lightweight Convolutional Neural Networks for Efficient and High-quality Pavement Crack Detection13 Sep 2021
- 2021A Novel Graph-Theoretic Deep Representation Learning Method for Multi-Label Remote Sensing Image Retrieval1 Jun 2021
- 2021WeGleNet: A Weakly-Supervised Convolutional Neural Network for the Semantic Segmentation of Gleason Grades in Prostate Histology Images21 May 2021
- 2021Learning Whole-Slide Segmentation from Inexact and Incomplete Labels using Tissue Graphs4 Mar 2021
- 2021CheXseg: Combining Expert Annotations with DNN-generated Saliency Maps for X-ray Segmentation21 Feb 2021
- 2021Expectation-Maximization Regularized Deep Learning for Weakly Supervised Tumor Segmentation for Glioblastoma21 Jan 2021
- 2022Deep Spectral Methods: A Surprisingly Strong Baseline for Unsupervised Semantic Segmentation and Localizationcited by 150
- 2023Towards Generic Image Manipulation Detection with Weakly-Supervised Self-Consistency Learningcited by 23
- 2021Learning Whole-Slide Segmentation from Inexact and Incomplete Labels using Tissue Graphscited by 22
- 2022Pointly-Supervised Panoptic Segmentationcited by 20
- 2023Weakly-Supervised Semantic Segmentation with Image-Level Labels: from Traditional Models to Foundation Modelscited by 19
- 2023Background Activation Suppression for Weakly Supervised Object Localization and Semantic Segmentationcited by 17
- 2023Weakly Supervised Joint Whole-Slide Segmentation and Classification in Prostate Cancercited by 10
- 2021WeGleNet: A Weakly-Supervised Convolutional Neural Network for the Semantic Segmentation of Gleason Grades in Prostate Histology Imagescited by 9
- 2023AME-CAM: Attentive Multiple-Exit CAM for Weakly Supervised Segmentation on MRI Brain Tumorcited by 8
- 2025WeakMedSAM: Weakly-Supervised Medical Image Segmentation via SAM with Sub-Class Exploration and Prompt Affinity Miningcited by 8
- 2021A Novel Graph-Theoretic Deep Representation Learning Method for Multi-Label Remote Sensing Image Retrievalcited by 7
- 2022Mixed-UNet: Refined Class Activation Mapping for Weakly-Supervised Semantic Segmentation with Multi-scale Inferencecited by 7
12 most cited of 33 All 33 (JSON)
- 2026Semantic Segmentation for Histopathology using Learned Regularization based on Global Proportions27 Apr 2026
- 2025A deep multiple instance learning approach based on coarse labels for high-resolution land-cover mapping8 Oct 2025
- 2025Depth Edge Alignment Loss: DEALing with Depth in Weakly Supervised Semantic Segmentation22 Sep 2025
- 2025A drone-based framework for coral habitat mapping via weakly supervised segmentation26 Aug 2025
- 2025Opening the black box of deep learning: Validating the statistical association between explainable artificial intelligence (XAI) and clinical domain knowledge in fundus image-based glaucoma diagnosis6 Apr 2025
- 2025WeakMedSAM: Weakly-Supervised Medical Image Segmentation via SAM with Sub-Class Exploration and Prompt Affinity Mining6 Mar 2025
- 2025Superpixel Boundary Correction for Weakly-Supervised Semantic Segmentation on Histopathology Images7 Jan 2025
- 2024Enhancing Weakly Supervised Semantic Segmentation for Fibrosis via Controllable Image Generation5 Nov 2024
- 2024Upsampling DINOv2 features for unsupervised vision tasks and weakly supervised materials segmentation20 Oct 2024
- 2023Weakly-Supervised Semantic Segmentation with Image-Level Labels: from Traditional Models to Foundation Models19 Oct 2023
- 2023Background Activation Suppression for Weakly Supervised Object Localization and Semantic Segmentation22 Sep 2023
- 2023Towards Generic Image Manipulation Detection with Weakly-Supervised Self-Consistency Learning3 Sep 2023
12 newest of 33 All 33 (JSON)