CT-GAN: Malicious Tampering of 3D Medical Imagery using Deep Learning
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Abstract (arXiv)
In 2018, clinics and hospitals were hit with numerous attacks leading to significant data breaches and interruptions in medical services. An attacker with access to medical records can do much more than hold the data for ransom or sell it on the black market. In this paper, we show how an attacker can use deep-learning to add or remove evidence of medical conditions from volumetric (3D) medical scans. An attacker may perform this act in order to stop a political candidate, sabotage research, commit insurance fraud, perform an act of terrorism, or even commit murder. We implement the attack using a 3D conditional GAN and show how the framework (CT-GAN) can be automated. Although the body is complex and 3D medical scans are very large, CT-GAN achieves realistic results which can be executed in milliseconds. To evaluate the attack, we focused on injecting and removing lung cancer from CT scans. We show how three expert radiologists and a state-of-the-art deep learning AI are highly susceptible to the attack. We also explore the attack surface of a modern radiology network and demonstrate one attack vector: we intercepted and manipulated CT scans in an active hospital network with a covert penetration test. Demo video: https://youtu.be/_mkRAArj-x0 Source code: https://github.com/ymirsky/CT-GAN
Key facts. Cited by 31 papers in the map (data through 7 Oct 2026). First posted on arXiv 11 Jan 2019.
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Citing papers per year: 2021: 10; 2022: 3; 2023: 3; 2024: 9; 2025: 2; 2026: 4.
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- 2021Collaborative Federated Learning For Healthcare: Multi-Modal COVID-19 Diagnosis at the Edgecited by 56
- 2022"Real Attackers Don't Compute Gradients": Bridging the Gap Between Adversarial ML Research and Practicecited by 55
- 2021The Threat of Offensive AI to Organizationscited by 37
- 2024Large Language Model Benchmarks in Medical Taskscited by 16
- 2021Data synthesis and adversarial networks: A review and meta-analysis in cancer imagingcited by 15
- 2023The Age of Synthetic Realities: Challenges and Opportunitiescited by 15
- 2023M3Dsynth: A dataset of medical 3D images with AI-generated local manipulationscited by 11
- 2021Jekyll: Attacking Medical Image Diagnostics using Deep Generative Modelscited by 10
- 2021IPatch: A Remote Adversarial Patchcited by 7
- 2021Lung Cancer Risk Estimation with Incomplete Data: A Joint Missing Imputation Perspectivecited by 5
- 2021Machine Learning based Medical Image Deepfake Detection: A Comparative Studycited by 5
- 2024Back-in-Time Diffusion: Unsupervised Detection of Medical Deepfakescited by 5
19 more
- 2021CT-SGAN: Computed Tomography Synthesis GANcited by 4
- 2022The Security of Deep Learning Defences for Medical Imagingcited by 4
- 2021Toward Generating Synthetic CT Volumes using a 3D-Conditional Generative Adversarial Networkcited by 3
- 2024Adversarially Robust Feature Learning for Breast Cancer Diagnosiscited by 3
- 2024Synthetic Medical Imaging Generation with Generative Adversarial Networks For Plain Radiographscited by 3
- 2023Can We Revitalize Interventional Healthcare with AI-XR Surgical Metaverses?cited by 2
- 2024SecGenAI: Enhancing Security of Cloud-based Generative AI Applications within Australian Critical Technologies of National Interestcited by 2
- 2024Localization of Synthetic Manipulations in Western Blot Imagescited by 2
- 2024SoK: Security and Privacy Risks of Healthcare AIcited by 2
- 2022GAN-based Medical Image Small Region Forgery Detection via a Two-Stage Cascade Frameworkcited by 1
- 2025Pathology-Aware Adaptive Watermarking for Text-Driven Medical Image Synthesiscited by 1
- 2026Grounding-Driven Attack: Improving Encoder-based Adversarial Transferability against Large Vision-Language Modelscited by 1
- 2021Redatuming physical systems using symmetric autoencoderscited by 0
- 2024Comparative Analysis of Deep Convolutional Neural Networks for Detecting Medical Image Deepfakescited by 0
- 2024Longitudinal Mammogram Exam-based Breast Cancer Diagnosis Models: Vulnerability to Adversarial Attackscited by 0
- 2025Filtered-ViT: A Robust Defense Against Multiple Adversarial Patch Attackscited by 0
- 2026Quantum-Inspired Reinforcement Learning for Secure and Sustainable AIoT-Driven Supply Chain Systemscited by 0
- 2026CTForensics: A Comprehensive Dataset and Method for AI-Generated CT Image Detectioncited by 0
- 2026HexMIL: Hierarchical Attention MIL for Ante-Hoc Explainable Detection of AI-Manipulated CT Volumescited by 0
- 2026HexMIL: Hierarchical Attention MIL for Ante-Hoc Explainable Detection of AI-Manipulated CT Volumes5 Aug 2026
- 2026CTForensics: A Comprehensive Dataset and Method for AI-Generated CT Image Detection2 Mar 2026
- 2026Grounding-Driven Attack: Improving Encoder-based Adversarial Transferability against Large Vision-Language Models10 Feb 2026
- 2026Quantum-Inspired Reinforcement Learning for Secure and Sustainable AIoT-Driven Supply Chain Systems29 Jan 2026
- 2025Filtered-ViT: A Robust Defense Against Multiple Adversarial Patch Attacks11 Nov 2025
- 2025Pathology-Aware Adaptive Watermarking for Text-Driven Medical Image Synthesis11 Mar 2025
- 2024Longitudinal Mammogram Exam-based Breast Cancer Diagnosis Models: Vulnerability to Adversarial Attacks29 Oct 2024
- 2024Large Language Model Benchmarks in Medical Tasks28 Oct 2024
- 2024SoK: Security and Privacy Risks of Healthcare AI11 Sep 2024
- 2024Localization of Synthetic Manipulations in Western Blot Images25 Aug 2024
- 2024Back-in-Time Diffusion: Unsupervised Detection of Medical Deepfakes21 Jul 2024
- 2024SecGenAI: Enhancing Security of Cloud-based Generative AI Applications within Australian Critical Technologies of National Interest1 Jul 2024
19 more
- 2024Synthetic Medical Imaging Generation with Generative Adversarial Networks For Plain Radiographs28 Mar 2024
- 2024Adversarially Robust Feature Learning for Breast Cancer Diagnosis13 Feb 2024
- 2024Comparative Analysis of Deep Convolutional Neural Networks for Detecting Medical Image Deepfakes8 Jan 2024
- 2023M3Dsynth: A dataset of medical 3D images with AI-generated local manipulations14 Sep 2023
- 2023The Age of Synthetic Realities: Challenges and Opportunities9 Jun 2023
- 2023Can We Revitalize Interventional Healthcare with AI-XR Surgical Metaverses?25 Mar 2023
- 2022"Real Attackers Don't Compute Gradients": Bridging the Gap Between Adversarial ML Research and Practice29 Dec 2022
- 2022GAN-based Medical Image Small Region Forgery Detection via a Two-Stage Cascade Framework30 May 2022
- 2022The Security of Deep Learning Defences for Medical Imaging21 Jan 2022
- 2021CT-SGAN: Computed Tomography Synthesis GAN14 Oct 2021
- 2021Machine Learning based Medical Image Deepfake Detection: A Comparative Study27 Sep 2021
- 2021Redatuming physical systems using symmetric autoencoders5 Aug 2021
- 2021Lung Cancer Risk Estimation with Incomplete Data: A Joint Missing Imputation Perspective25 Jul 2021
- 2021Data synthesis and adversarial networks: A review and meta-analysis in cancer imaging20 Jul 2021
- 2021The Threat of Offensive AI to Organizations30 Jun 2021
- 2021IPatch: A Remote Adversarial Patch30 Apr 2021
- 2021Jekyll: Attacking Medical Image Diagnostics using Deep Generative Models5 Apr 2021
- 2021Toward Generating Synthetic CT Volumes using a 3D-Conditional Generative Adversarial Network2 Apr 2021
- 2021Collaborative Federated Learning For Healthcare: Multi-Modal COVID-19 Diagnosis at the Edge19 Jan 2021
- 2021Collaborative Federated Learning For Healthcare: Multi-Modal COVID-19 Diagnosis at the Edgecited by 56
- 2022"Real Attackers Don't Compute Gradients": Bridging the Gap Between Adversarial ML Research and Practicecited by 55
- 2021The Threat of Offensive AI to Organizationscited by 37
- 2024Large Language Model Benchmarks in Medical Taskscited by 16
- 2021Data synthesis and adversarial networks: A review and meta-analysis in cancer imagingcited by 15
- 2023The Age of Synthetic Realities: Challenges and Opportunitiescited by 15
- 2023M3Dsynth: A dataset of medical 3D images with AI-generated local manipulationscited by 11
- 2021Jekyll: Attacking Medical Image Diagnostics using Deep Generative Modelscited by 10
- 2021IPatch: A Remote Adversarial Patchcited by 7
- 2021Lung Cancer Risk Estimation with Incomplete Data: A Joint Missing Imputation Perspectivecited by 5
- 2021Machine Learning based Medical Image Deepfake Detection: A Comparative Studycited by 5
- 2021CT-SGAN: Computed Tomography Synthesis GANcited by 4
12 most cited of 28 All 28 (JSON)
- 2026HexMIL: Hierarchical Attention MIL for Ante-Hoc Explainable Detection of AI-Manipulated CT Volumes5 Aug 2026
- 2026CTForensics: A Comprehensive Dataset and Method for AI-Generated CT Image Detection2 Mar 2026
- 2026Quantum-Inspired Reinforcement Learning for Secure and Sustainable AIoT-Driven Supply Chain Systems29 Jan 2026
- 2025Filtered-ViT: A Robust Defense Against Multiple Adversarial Patch Attacks11 Nov 2025
- 2024Longitudinal Mammogram Exam-based Breast Cancer Diagnosis Models: Vulnerability to Adversarial Attacks29 Oct 2024
- 2024Large Language Model Benchmarks in Medical Tasks28 Oct 2024
- 2024SoK: Security and Privacy Risks of Healthcare AI11 Sep 2024
- 2024Localization of Synthetic Manipulations in Western Blot Images25 Aug 2024
- 2024SecGenAI: Enhancing Security of Cloud-based Generative AI Applications within Australian Critical Technologies of National Interest1 Jul 2024
- 2024Synthetic Medical Imaging Generation with Generative Adversarial Networks For Plain Radiographs28 Mar 2024
- 2024Adversarially Robust Feature Learning for Breast Cancer Diagnosis13 Feb 2024
- 2024Comparative Analysis of Deep Convolutional Neural Networks for Detecting Medical Image Deepfakes8 Jan 2024
12 newest of 28 All 28 (JSON)