TractSeg - Fast and accurate white matter tract segmentation
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Abstract (arXiv)
The individual course of white matter fiber tracts is an important key for analysis of white matter characteristics in healthy and diseased brains. Uniquely, diffusion-weighted MRI tractography in combination with region-based or clustering-based selection of streamlines allows for the in-vivo delineation and analysis of anatomically well known tracts. This, however, currently requires complex, computationally intensive and tedious-to-set-up processing pipelines. TractSeg is a novel convolutional neural network-based approach that directly segments tracts in the field of fiber orientation distribution function (fODF) peaks without requiring tractography, image registration or parcellation. We demonstrate in 105 subjects from the Human Connectome Project that the proposed approach is much faster than existing methods while providing unprecedented accuracy. The code and data are openly available at https://github.com/MIC-DKFZ/TractSeg/ and https://doi.org/10.5281/zenodo.1088277, respectively.
Key facts. Cited by 52 papers in the map (data through 14 Oct 2026). First posted on arXiv 18 May 2018.
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Citing papers per year: 2021: 3; 2022: 8; 2023: 13; 2024: 9; 2025: 12; 2026: 7.
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- 2022Superficial White Matter Analysis: An Efficient Point-cloud-based Deep Learning Framework with Supervised Contrastive Learning for Consistent Tractography Parcellation across Populations and dMRI Acquisitionscited by 20
- 2021Deep Fiber Clustering: Anatomically Informed Unsupervised Deep Learning for Fast and Effective White Matter Parcellationcited by 16
- 2022Deep fiber clustering: Anatomically informed fiber clustering with self-supervised deep learning for fast and effective tractography parcellationcited by 14
- 2022SupWMA: Consistent and Efficient Tractography Parcellation of Superficial White Matter with Deep Learningcited by 13
- 2021Fast and Scalable Optimal Transport for Brain Tractogramscited by 12
- 2023TractCloud: Registration-free tractography parcellation with a novel local-global streamline point cloud representationcited by 11
- 2024Diffusion MRI with Machine Learningcited by 11
- 2023Reconstructing the somatotopic organization of the corticospinal tract remains a challenge for modern tractography methodscited by 7
- 2023One-Shot Segmentation of Novel White Matter Tracts via Extensive Data Augmentationcited by 5
- 2024Field-of-View Extension for Brain Diffusion MRI via Deep Generative Modelscited by 5
- 2022FIESTA: Autoencoders for accurate fiber segmentation in tractographycited by 4
- 2023A Registration- and Uncertainty-based Framework for White Matter Tract Segmentation With Only One Annotated Subjectcited by 4
38 more
- 2024FOD-Swin-Net: angular super resolution of fiber orientation distribution using a transformer-based deep modelcited by 4
- 2024A Novel Deep Learning Tractography Fiber Clustering Framework for Functionally Consistent White Matter Parcellation Using Multimodal Diffusion MRI and Functional MRIcited by 4
- 2021Knowledge Transfer for Few-shot Segmentation of Novel White Matter Tractscited by 3
- 2023atTRACTive: Semi-automatic white matter tract segmentation using active learningcited by 3
- 2023Recovering high-quality FODs from a reduced number of diffusion-weighted images using a model-driven deep learning architecturecited by 3
- 2024Detailed delineation of the fetal brain in diffusion MRI via multi-task learningcited by 3
- 2025TractCloud-FOV: Deep Learning-based Robust Tractography Parcellation in Diffusion MRI with Incomplete Field of Viewcited by 3
- 2023TBSS++: A novel computational method for Tract-Based Spatial Statisticscited by 2
- 2023BundleSeg: A versatile, reliable and reproducible approach to white matter bundle segmentationcited by 2
- 2024Anatomically Constrained Tractography of the Fetal Braincited by 2
- 2024Multi-Modality Conditioned Variational U-Net for Field-of-View Extension in Brain Diffusion MRIcited by 2
- 2025MultiCo3D: Multi-Label Voxel Contrast for One-Shot Incremental Segmentation of 3D Neuroimagescited by 2
- 2025DDTracking: A Deep Generative Framework for Diffusion MRI Tractography with Streamline Local-Global Spatiotemporal Modelingcited by 2
- 2022Assessing Streamline Plausibility Through Randomized Iterative Spherical-Deconvolution Informed Tractogram Filteringcited by 1
- 2022DeepRGVP: A Novel Microstructure-Informed Supervised Contrastive Learning Framework for Automated Identification Of The Retinogeniculate Pathway Using dMRI Tractographycited by 1
- 2022Supervised Tractogram Filtering using Geometric Deep Learningcited by 1
- 2023Direct segmentation of brain white matter tracts in diffusion MRIcited by 1
- 2024Streamline tractography of the fetal brain in utero with machine learningcited by 1
- 2024Enhancing Angular Resolution via Directionality Encoding and Geometric Constraints in Brain Diffusion Tensor Imagingcited by 1
- 2025TractoGPT: A GPT architecture for White Matter Segmentationcited by 1
- 2025A Novel Streamline-based diffusion MRI Tractography Registration Method with Probabilistic Keypoint Detectioncited by 1
- 2025Exploring the robustness of TractOracle methods in RL-based tractographycited by 1
- 2025Tractography-Guided Dual-Label Collaborative Learning for Multi-Modal Cranial Nerves Parcellationcited by 1
- 2025DMVFC: Deep Learning Based Functionally Consistent Tractography Fiber Clustering Using Multimodal Diffusion MRI and Functional MRIcited by 1
- 2026SIINR: Structurally Informed Implicit Neural Representations for super-resolution with uncertainty quantification of clinical quality diffusion MRI datasetscited by 1
- 2022An overview of deep learning in medical imagingcited by 0
- 2023GeoLab: Geometry-based Tractography Parcellation of Superficial White Mattercited by 0
- 2023Bundle-specific Tractogram Distribution Estimation Using Higher-order Streamline Differential Equationcited by 0
- 2023Merging multiple input descriptors and supervisors in a deep neural network for tractogram filteringcited by 0
- 2023Better Generalization of White Matter Tract Segmentation to Arbitrary Datasets with Scaled Residual Bootstrapcited by 0
- 2025DeepMultiConnectome: Deep Multi-Task Prediction of Structural Connectomes Directly from Diffusion MRI Tractographycited by 0
- 2025Convergent and divergent connectivity patterns of the arcuate fasciculus in macaques and humanscited by 0
- 2025Visionerves: Automatic and Reproducible Hybrid AI for Peripheral Nervous System Recognition Applied to Endometriosis Casescited by 0
- 2025A Novel Dual-Stream Framework for dMRI Tractography Streamline Classification with Joint dMRI and fMRI Datacited by 0
- 2026TractRLFusion: A GPT-Based Multi-Critic Policy Fusion Framework for Fiber Tractographycited by 0
- 2026TrackletGPT: A Language-like GPT Framework for White Matter Tract Segmentationcited by 0
- 2026Diffusion MRI Transformer with a Diffusion Space Rotary Positional Embedding (D-RoPE)cited by 0
- 2026A foundation for systematic analysis of transformers and RNNs for tractographycited by 0
50 most cited of 52 All 52 (JSON)
- 2026dMRI-F: A Foundation Model for Generalizable Diffusion MRI Analysis from Sparse Acquisitions13 Oct 2026
- 2026Generalizable field of view extension for diffusion MRI via conditional flow matching12 Oct 2026
- 2026A foundation for systematic analysis of transformers and RNNs for tractography1 Oct 2026
- 2026SIINR: Structurally Informed Implicit Neural Representations for super-resolution with uncertainty quantification of clinical quality diffusion MRI datasets22 Jul 2026
- 2026Diffusion MRI Transformer with a Diffusion Space Rotary Positional Embedding (D-RoPE)26 Mar 2026
- 2026TrackletGPT: A Language-like GPT Framework for White Matter Tract Segmentation20 Jan 2026
- 2026TractRLFusion: A GPT-Based Multi-Critic Policy Fusion Framework for Fiber Tractography20 Jan 2026
- 2025A Novel Dual-Stream Framework for dMRI Tractography Streamline Classification with Joint dMRI and fMRI Data24 Nov 2025
- 2025DMVFC: Deep Learning Based Functionally Consistent Tractography Fiber Clustering Using Multimodal Diffusion MRI and Functional MRI24 Oct 2025
- 2025Visionerves: Automatic and Reproducible Hybrid AI for Peripheral Nervous System Recognition Applied to Endometriosis Cases18 Sep 2025
- 2025DDTracking: A Deep Generative Framework for Diffusion MRI Tractography with Streamline Local-Global Spatiotemporal Modeling6 Aug 2025
- 2025Tractography-Guided Dual-Label Collaborative Learning for Multi-Modal Cranial Nerves Parcellation3 Aug 2025
38 more
- 2025Exploring the robustness of TractOracle methods in RL-based tractography15 Jul 2025
- 2025Convergent and divergent connectivity patterns of the arcuate fasciculus in macaques and humans24 Jun 2025
- 2025DeepMultiConnectome: Deep Multi-Task Prediction of Structural Connectomes Directly from Diffusion MRI Tractography27 May 2025
- 2025MultiCo3D: Multi-Label Voxel Contrast for One-Shot Incremental Segmentation of 3D Neuroimages9 Mar 2025
- 2025A Novel Streamline-based diffusion MRI Tractography Registration Method with Probabilistic Keypoint Detection4 Mar 2025
- 2025TractCloud-FOV: Deep Learning-based Robust Tractography Parcellation in Diffusion MRI with Incomplete Field of View28 Feb 2025
- 2025TractoGPT: A GPT architecture for White Matter Segmentation26 Jan 2025
- 2024A Novel Deep Learning Tractography Fiber Clustering Framework for Functionally Consistent White Matter Parcellation Using Multimodal Diffusion MRI and Functional MRI4 Nov 2024
- 2024Multi-Modality Conditioned Variational U-Net for Field-of-View Extension in Brain Diffusion MRI20 Sep 2024
- 2024Enhancing Angular Resolution via Directionality Encoding and Geometric Constraints in Brain Diffusion Tensor Imaging11 Sep 2024
- 2024Detailed delineation of the fetal brain in diffusion MRI via multi-task learning26 Aug 2024
- 2024Streamline tractography of the fetal brain in utero with machine learning26 Aug 2024
- 2024Field-of-View Extension for Brain Diffusion MRI via Deep Generative Models6 May 2024
- 2024Anatomically Constrained Tractography of the Fetal Brain4 Mar 2024
- 2024FOD-Swin-Net: angular super resolution of fiber orientation distribution using a transformer-based deep model19 Feb 2024
- 2024Diffusion MRI with Machine Learning1 Jan 2024
- 2023Better Generalization of White Matter Tract Segmentation to Arbitrary Datasets with Scaled Residual Bootstrap25 Sep 2023
- 2023BundleSeg: A versatile, reliable and reproducible approach to white matter bundle segmentation21 Aug 2023
- 2023Recovering high-quality FODs from a reduced number of diffusion-weighted images using a model-driven deep learning architecture28 Jul 2023
- 2023TractCloud: Registration-free tractography parcellation with a novel local-global streamline point cloud representation18 Jul 2023
- 2023Merging multiple input descriptors and supervisors in a deep neural network for tractogram filtering11 Jul 2023
- 2023TBSS++: A novel computational method for Tract-Based Spatial Statistics7 Jul 2023
- 2023Bundle-specific Tractogram Distribution Estimation Using Higher-order Streamline Differential Equation6 Jul 2023
- 2023Direct segmentation of brain white matter tracts in diffusion MRI5 Jul 2023
- 2023Reconstructing the somatotopic organization of the corticospinal tract remains a challenge for modern tractography methods9 Jun 2023
- 2023atTRACTive: Semi-automatic white matter tract segmentation using active learning30 May 2023
- 2023A Registration- and Uncertainty-based Framework for White Matter Tract Segmentation With Only One Annotated Subject25 Mar 2023
- 2023One-Shot Segmentation of Novel White Matter Tracts via Extensive Data Augmentation13 Mar 2023
- 2023GeoLab: Geometry-based Tractography Parcellation of Superficial White Matter2 Mar 2023
- 2022Supervised Tractogram Filtering using Geometric Deep Learning6 Dec 2022
- 2022FIESTA: Autoencoders for accurate fiber segmentation in tractography30 Nov 2022
- 2022DeepRGVP: A Novel Microstructure-Informed Supervised Contrastive Learning Framework for Automated Identification Of The Retinogeniculate Pathway Using dMRI Tractography15 Nov 2022
- 2022Superficial White Matter Analysis: An Efficient Point-cloud-based Deep Learning Framework with Supervised Contrastive Learning for Consistent Tractography Parcellation across Populations and dMRI Acquisitions18 Jul 2022
- 2022Assessing Streamline Plausibility Through Randomized Iterative Spherical-Deconvolution Informed Tractogram Filtering10 May 2022
- 2022Deep fiber clustering: Anatomically informed fiber clustering with self-supervised deep learning for fast and effective tractography parcellation2 May 2022
- 2022An overview of deep learning in medical imaging17 Feb 2022
- 2022SupWMA: Consistent and Efficient Tractography Parcellation of Superficial White Matter with Deep Learning29 Jan 2022
- 2021Deep Fiber Clustering: Anatomically Informed Unsupervised Deep Learning for Fast and Effective White Matter Parcellation11 Jul 2021
50 newest of 52 All 52 (JSON)
- 2022Superficial White Matter Analysis: An Efficient Point-cloud-based Deep Learning Framework with Supervised Contrastive Learning for Consistent Tractography Parcellation across Populations and dMRI Acquisitionscited by 20
- 2021Deep Fiber Clustering: Anatomically Informed Unsupervised Deep Learning for Fast and Effective White Matter Parcellationcited by 16
- 2022Deep fiber clustering: Anatomically informed fiber clustering with self-supervised deep learning for fast and effective tractography parcellationcited by 14
- 2022SupWMA: Consistent and Efficient Tractography Parcellation of Superficial White Matter with Deep Learningcited by 13
- 2021Fast and Scalable Optimal Transport for Brain Tractogramscited by 12
- 2023TractCloud: Registration-free tractography parcellation with a novel local-global streamline point cloud representationcited by 11
- 2024Diffusion MRI with Machine Learningcited by 11
- 2023Reconstructing the somatotopic organization of the corticospinal tract remains a challenge for modern tractography methodscited by 7
- 2023One-Shot Segmentation of Novel White Matter Tracts via Extensive Data Augmentationcited by 5
- 2024Field-of-View Extension for Brain Diffusion MRI via Deep Generative Modelscited by 5
- 2022FIESTA: Autoencoders for accurate fiber segmentation in tractographycited by 4
- 2023A Registration- and Uncertainty-based Framework for White Matter Tract Segmentation With Only One Annotated Subjectcited by 4
12 most cited of 51 All 51 (JSON)
- 2026dMRI-F: A Foundation Model for Generalizable Diffusion MRI Analysis from Sparse Acquisitions13 Oct 2026
- 2026A foundation for systematic analysis of transformers and RNNs for tractography1 Oct 2026
- 2026SIINR: Structurally Informed Implicit Neural Representations for super-resolution with uncertainty quantification of clinical quality diffusion MRI datasets22 Jul 2026
- 2026Diffusion MRI Transformer with a Diffusion Space Rotary Positional Embedding (D-RoPE)26 Mar 2026
- 2026TrackletGPT: A Language-like GPT Framework for White Matter Tract Segmentation20 Jan 2026
- 2026TractRLFusion: A GPT-Based Multi-Critic Policy Fusion Framework for Fiber Tractography20 Jan 2026
- 2025A Novel Dual-Stream Framework for dMRI Tractography Streamline Classification with Joint dMRI and fMRI Data24 Nov 2025
- 2025DMVFC: Deep Learning Based Functionally Consistent Tractography Fiber Clustering Using Multimodal Diffusion MRI and Functional MRI24 Oct 2025
- 2025Visionerves: Automatic and Reproducible Hybrid AI for Peripheral Nervous System Recognition Applied to Endometriosis Cases18 Sep 2025
- 2025DDTracking: A Deep Generative Framework for Diffusion MRI Tractography with Streamline Local-Global Spatiotemporal Modeling6 Aug 2025
- 2025Tractography-Guided Dual-Label Collaborative Learning for Multi-Modal Cranial Nerves Parcellation3 Aug 2025
- 2025Exploring the robustness of TractOracle methods in RL-based tractography15 Jul 2025
12 newest of 51 All 51 (JSON)