Sharpness-aware Low dose CT denoising using conditional generative adversarial network
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Abstract (arXiv)
Low Dose Computed Tomography (LDCT) has offered tremendous benefits in radiation restricted applications, but the quantum noise as resulted by the insufficient number of photons could potentially harm the diagnostic performance. Current image-based denoising methods tend to produce a blur effect on the final reconstructed results especially in high noise levels. In this paper, a deep learning based approach was proposed to mitigate this problem. An adversarially trained network and a sharpness detection network were trained to guide the training process. Experiments on both simulated and real dataset shows that the results of the proposed method have very small resolution loss and achieves better performance relative to the-state-of-art methods both quantitatively and visually.
Key facts. Cited by 28 papers in the map (data through 7 Oct 2026). First posted on arXiv 22 Aug 2017.
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Citing papers per year: 2021: 2; 2022: 3; 2023: 7; 2024: 7; 2025: 3; 2026: 6.
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- 2023Image Denoising: The Deep Learning Revolution and Beyond -- A Survey Paper --cited by 71
- 2023CoreDiff: Contextual Error-Modulated Generalized Diffusion Model for Low-Dose CT Denoising and Generalizationcited by 51
- 2021DU-GAN: Generative Adversarial Networks with Dual-Domain U-Net Based Discriminators for Low-Dose CT Denoisingcited by 46
- 2023Diffusion Probabilistic Priors for Zero-Shot Low-Dose CT Image Denoisingcited by 21
- 2022A review of Generative Adversarial Networks for Electronic Health Records: applications, evaluation measures and data sourcescited by 13
- 2024DenoMamba: A fused state-space model for low-dose CT denoisingcited by 11
- 2023The Perception-Robustness Tradeoff in Deterministic Image Restorationcited by 7
- 2022Posterior temperature optimized Bayesian models for inverse problems in medical imagingcited by 3
- 2023A hybrid quantum-classical conditional generative adversarial network algorithm for human-centered paradigm in cloudcited by 3
- 2022A SSIM Guided cGAN Architecture For Clinically Driven Generative Image Synthesis of Multiplexed Spatial Proteomics Channelscited by 2
- 2024Efficient Quantum Circuits for Machine Learning Activation Functions including Constant T-depth ReLUcited by 2
- 2024HAGAN: Hybrid Augmented Generative Adversarial Network for Medical Image Synthesiscited by 2
16 more
- 2025FoundDiff: Foundational Diffusion Model for Generalizable Low-Dose CT Denoisingcited by 2
- 2023Learned Interferometric Imaging for the SPIDER Instrumentcited by 1
- 2024Enhanced Low-Dose CT Image Reconstruction by Domain and Task Shifting Gaussian Denoiserscited by 1
- 2024Iterative CT Reconstruction via Latent Variable Optimization of Shallow Diffusion Modelscited by 1
- 2025A Denoising Framework for Real-World Ultra-Low-Dose Lung CT Images Based on an Image Purification Strategycited by 1
- 2026Three-dimensional visualization of X-ray micro-CT with large-scale datasets: Efficiency and accuracy for real-time interactioncited by 1
- 2021Window-Level is a Strong Denoising Surrogatecited by 0
- 2023Diffusion Denoising for Low-Dose-CT Modelcited by 0
- 2024A Low-dose CT Reconstruction Network Based on TV-regularized OSEM Algorithmcited by 0
- 2024GAN-Based Architecture for Low-dose Computed Tomography Imaging Denoisingcited by 0
- 2025Physics-Guided Null-Space Diffusion with Sparse Masking for Corrective Sparse-View CT Reconstructioncited by 0
- 2026IPv2: An Improved Image Purification Strategy for Real-World Ultra-Low-Dose Lung CT Denoisingcited by 0
- 2026PatchDenoiser: Parameter-efficient multi-scale patch learning and fusion denoiser for Low-dose CT imagingcited by 0
- 2026Rethinking Cross-Dose PET Denoising: Mitigating Averaging Effects via Residual Noise Learningcited by 0
- 2026CT-DegradBench: A Physics-Informed Benchmark for CT Degradation Detection and Severity Estimationcited by 0
- 2026GenDiff: A Dose and Anatomy Aware Diffusion Model with Structural Prior Refinement for Low-Dose CT Reconstruction and Generalizationcited by 0
- 2026GenDiff: A Dose and Anatomy Aware Diffusion Model with Structural Prior Refinement for Low-Dose CT Reconstruction and Generalization11 Jul 2026
- 2026CT-DegradBench: A Physics-Informed Benchmark for CT Degradation Detection and Severity Estimation14 May 2026
- 2026Rethinking Cross-Dose PET Denoising: Mitigating Averaging Effects via Residual Noise Learning18 Apr 2026
- 2026PatchDenoiser: Parameter-efficient multi-scale patch learning and fusion denoiser for Low-dose CT imaging25 Feb 2026
- 2026IPv2: An Improved Image Purification Strategy for Real-World Ultra-Low-Dose Lung CT Denoising22 Feb 2026
- 2026Three-dimensional visualization of X-ray micro-CT with large-scale datasets: Efficiency and accuracy for real-time interaction21 Jan 2026
- 2025A Denoising Framework for Real-World Ultra-Low-Dose Lung CT Images Based on an Image Purification Strategy8 Oct 2025
- 2025Physics-Guided Null-Space Diffusion with Sparse Masking for Corrective Sparse-View CT Reconstruction7 Sep 2025
- 2025FoundDiff: Foundational Diffusion Model for Generalizable Low-Dose CT Denoising24 Aug 2025
- 2024GAN-Based Architecture for Low-dose Computed Tomography Imaging Denoising14 Nov 2024
- 2024DenoMamba: A fused state-space model for low-dose CT denoising19 Sep 2024
- 2024A Low-dose CT Reconstruction Network Based on TV-regularized OSEM Algorithm25 Aug 2024
16 more
- 2024Iterative CT Reconstruction via Latent Variable Optimization of Shallow Diffusion Models6 Aug 2024
- 2024HAGAN: Hybrid Augmented Generative Adversarial Network for Medical Image Synthesis8 May 2024
- 2024Efficient Quantum Circuits for Machine Learning Activation Functions including Constant T-depth ReLU9 Apr 2024
- 2024Enhanced Low-Dose CT Image Reconstruction by Domain and Task Shifting Gaussian Denoisers6 Mar 2024
- 2023The Perception-Robustness Tradeoff in Deterministic Image Restoration14 Nov 2023
- 2023A hybrid quantum-classical conditional generative adversarial network algorithm for human-centered paradigm in cloud30 Sep 2023
- 2023Diffusion Probabilistic Priors for Zero-Shot Low-Dose CT Image Denoising25 May 2023
- 2023CoreDiff: Contextual Error-Modulated Generalized Diffusion Model for Low-Dose CT Denoising and Generalization4 Apr 2023
- 2023Diffusion Denoising for Low-Dose-CT Model27 Jan 2023
- 2023Learned Interferometric Imaging for the SPIDER Instrument24 Jan 2023
- 2023Image Denoising: The Deep Learning Revolution and Beyond -- A Survey Paper --9 Jan 2023
- 2022A SSIM Guided cGAN Architecture For Clinically Driven Generative Image Synthesis of Multiplexed Spatial Proteomics Channels20 May 2022
- 2022A review of Generative Adversarial Networks for Electronic Health Records: applications, evaluation measures and data sources14 Mar 2022
- 2022Posterior temperature optimized Bayesian models for inverse problems in medical imaging2 Feb 2022
- 2021DU-GAN: Generative Adversarial Networks with Dual-Domain U-Net Based Discriminators for Low-Dose CT Denoising24 Aug 2021
- 2021Window-Level is a Strong Denoising Surrogate15 May 2021
- 2023CoreDiff: Contextual Error-Modulated Generalized Diffusion Model for Low-Dose CT Denoising and Generalizationcited by 51
- 2023Diffusion Probabilistic Priors for Zero-Shot Low-Dose CT Image Denoisingcited by 21
- 2025FoundDiff: Foundational Diffusion Model for Generalizable Low-Dose CT Denoisingcited by 2
- 2024Iterative CT Reconstruction via Latent Variable Optimization of Shallow Diffusion Modelscited by 1
- 2025Physics-Guided Null-Space Diffusion with Sparse Masking for Corrective Sparse-View CT Reconstructioncited by 0
- 2026GenDiff: A Dose and Anatomy Aware Diffusion Model with Structural Prior Refinement for Low-Dose CT Reconstruction and Generalizationcited by 0
- 2026GenDiff: A Dose and Anatomy Aware Diffusion Model with Structural Prior Refinement for Low-Dose CT Reconstruction and Generalization11 Jul 2026
- 2025Physics-Guided Null-Space Diffusion with Sparse Masking for Corrective Sparse-View CT Reconstruction7 Sep 2025
- 2025FoundDiff: Foundational Diffusion Model for Generalizable Low-Dose CT Denoising24 Aug 2025
- 2024Iterative CT Reconstruction via Latent Variable Optimization of Shallow Diffusion Models6 Aug 2024
- 2023Diffusion Probabilistic Priors for Zero-Shot Low-Dose CT Image Denoising25 May 2023
- 2023CoreDiff: Contextual Error-Modulated Generalized Diffusion Model for Low-Dose CT Denoising and Generalization4 Apr 2023
- 2023Image Denoising: The Deep Learning Revolution and Beyond -- A Survey Paper --cited by 71
- 2021DU-GAN: Generative Adversarial Networks with Dual-Domain U-Net Based Discriminators for Low-Dose CT Denoisingcited by 46
- 2022A review of Generative Adversarial Networks for Electronic Health Records: applications, evaluation measures and data sourcescited by 13
- 2024DenoMamba: A fused state-space model for low-dose CT denoisingcited by 11
- 2023The Perception-Robustness Tradeoff in Deterministic Image Restorationcited by 7
- 2022Posterior temperature optimized Bayesian models for inverse problems in medical imagingcited by 3
- 2023A hybrid quantum-classical conditional generative adversarial network algorithm for human-centered paradigm in cloudcited by 3
- 2022A SSIM Guided cGAN Architecture For Clinically Driven Generative Image Synthesis of Multiplexed Spatial Proteomics Channelscited by 2
- 2024Efficient Quantum Circuits for Machine Learning Activation Functions including Constant T-depth ReLUcited by 2
- 2024HAGAN: Hybrid Augmented Generative Adversarial Network for Medical Image Synthesiscited by 2
- 2023Learned Interferometric Imaging for the SPIDER Instrumentcited by 1
- 2024Enhanced Low-Dose CT Image Reconstruction by Domain and Task Shifting Gaussian Denoiserscited by 1
12 most cited of 22 All 22 (JSON)
- 2026CT-DegradBench: A Physics-Informed Benchmark for CT Degradation Detection and Severity Estimation14 May 2026
- 2026Rethinking Cross-Dose PET Denoising: Mitigating Averaging Effects via Residual Noise Learning18 Apr 2026
- 2026PatchDenoiser: Parameter-efficient multi-scale patch learning and fusion denoiser for Low-dose CT imaging25 Feb 2026
- 2026IPv2: An Improved Image Purification Strategy for Real-World Ultra-Low-Dose Lung CT Denoising22 Feb 2026
- 2026Three-dimensional visualization of X-ray micro-CT with large-scale datasets: Efficiency and accuracy for real-time interaction21 Jan 2026
- 2025A Denoising Framework for Real-World Ultra-Low-Dose Lung CT Images Based on an Image Purification Strategy8 Oct 2025
- 2024GAN-Based Architecture for Low-dose Computed Tomography Imaging Denoising14 Nov 2024
- 2024DenoMamba: A fused state-space model for low-dose CT denoising19 Sep 2024
- 2024A Low-dose CT Reconstruction Network Based on TV-regularized OSEM Algorithm25 Aug 2024
- 2024HAGAN: Hybrid Augmented Generative Adversarial Network for Medical Image Synthesis8 May 2024
- 2024Efficient Quantum Circuits for Machine Learning Activation Functions including Constant T-depth ReLU9 Apr 2024
- 2024Enhanced Low-Dose CT Image Reconstruction by Domain and Task Shifting Gaussian Denoisers6 Mar 2024
12 newest of 22 All 22 (JSON)