# ChemArgus: Automated Scientific Diagnostics for Lab-Grade Multimodal Chemistry Reasoning: A Frontier Benchmark

arXiv: https://arxiv.org/abs/2610.20012 · HTML: https://mlsanity.com/paper/2610.20012/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Clinical and biomedical applications, one of 17 directions in LLM reasoning.
- Builds on 60 of its 68 references that are in the map.
- First posted on arXiv 14 Oct 2026.

## Placed in

- LLM reasoning / [Clinical and biomedical applications](https://mlsanity.com/lr/clinical-and-biomedical-applications/)

## Builds on (most cited first, 30 of 60)

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- [Visual Instruction Tuning](https://mlsanity.com/paper/2304.08485/) (2023)
- [Think you have Solved Question Answering? Try ARC, the AI2 Reasoning Challenge](https://mlsanity.com/paper/1803.05457/) (2018)
- [Qwen2-VL: Enhancing Vision-Language Model's Perception of the World at Any Resolution](https://mlsanity.com/paper/2409.12191/) (2024)
- [SWE-bench: Can Language Models Resolve Real-World GitHub Issues?](https://mlsanity.com/paper/2310.06770/) (2023)
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- [GPQA: A Graduate-Level Google-Proof Q&A Benchmark](https://mlsanity.com/paper/2311.12022/) (2023)
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- [InternVL: Scaling up Vision Foundation Models and Aligning for Generic Visual-Linguistic Tasks](https://mlsanity.com/paper/2312.14238/) (2023)
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- [Beyond the Imitation Game: Quantifying and extrapolating the capabilities of language models](https://mlsanity.com/paper/2206.04615/) (2022)
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- [MMLU-Pro: A More Robust and Challenging Multi-Task Language Understanding Benchmark](https://mlsanity.com/paper/2406.01574/) (2024)
- [MathVista: Evaluating Mathematical Reasoning of Foundation Models in Visual Contexts](https://mlsanity.com/paper/2310.02255/) (2023)
- [ChartQA: A Benchmark for Question Answering about Charts with Visual and Logical Reasoning](https://mlsanity.com/paper/2203.10244/) (2022)
- [DocVQA: A Dataset for VQA on Document Images](https://mlsanity.com/paper/2007.00398/) (2020)
- [AgentBench: Evaluating LLMs as Agents](https://mlsanity.com/paper/2308.03688/) (2023)
- [Kimi k1.5: Scaling Reinforcement Learning with LLMs](https://mlsanity.com/paper/2501.12599/) (2025)
- [OSWorld: Benchmarking Multimodal Agents for Open-Ended Tasks in Real Computer Environments](https://mlsanity.com/paper/2404.07972/) (2024)
- [Chatbot Arena: An Open Platform for Evaluating LLMs by Human Preference](https://mlsanity.com/paper/2403.04132/) (2024)
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- [GAIA: a benchmark for General AI Assistants](https://mlsanity.com/paper/2311.12983/) (2023)

## Abstract (arXiv)

Chemistry evaluation has moved past multiple-choice probes toward open-ended expert problems, yet the benchmarks that define the current frontier still score answer endpoints alone. Such scoring conflates memorized facts with stepwise derivation, treats visual and textual inputs as interchangeable, and confounds long-horizon planning with stepwise execution. These blind spots prevent any diagnosis of where the reasoning chain breaks in a model. We present ChemArgus, a competition-level chemistry benchmark drawn from chemistry competition material, textbooks, and research papers, whose scoring replaces the answer endpoint with three measurement properties. Fine-grained scoring grades every subquestion point by point with partial credit, so a score lands at the level of the step rather than the outcome. Multimodal capability is priced on every problem containing a real image, paired with a controlled text description, so visual understanding is measured against text on identical tasks. Diagnostic attribution reads paired metrics that share one scoring unit and differ only in context construction, so a gap between two scores isolates a single cause, namely integration, propagation, or local reasoning. GPT-5.6-Sol scores 23.2% on unassisted whole-problem solving against 28.8% and 30.4% under the two sequential metrics, a gap measuring the integration burden. Through rubric partial credit and these cause-isolating score gaps, ChemArgus shows not only whether a model answers chemistry correctly but where its reasoning chain fails, so that every score it reports doubles as a diagnosis, a readout of the chain rather than a verdict, aiming to guide language models step by step on their path toward chemistry expertise, one corrected step at a time, each step priced by the rubric, point by point.