# S3-PnP: Plug-and-Play Denoising for Scientific Imaging with Self-Supervised Score Priors

arXiv: https://arxiv.org/abs/2610.18458 · HTML: https://mlsanity.com/paper/2610.18458/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 37 of its 46 references that are in the map.
- First posted on arXiv 13 Oct 2026.

## Builds on (most cited first, 30 of 37)

- [SwinIR: Image Restoration Using Swin Transformer](https://mlsanity.com/paper/2108.10257/) (2021)
- [Diffusion Posterior Sampling for General Noisy Inverse Problems](https://mlsanity.com/paper/2209.14687/) (2022)
- [Denoising Diffusion Restoration Models](https://mlsanity.com/paper/2201.11793/) (2022)
- [Zero-Shot Image Restoration Using Denoising Diffusion Null-Space Model](https://mlsanity.com/paper/2212.00490/) (2022)
- [Noise2Void - Learning Denoising from Single Noisy Images](https://mlsanity.com/paper/1811.10980/) (2018)
- [Denoising Diffusion Models for Plug-and-Play Image Restoration](https://mlsanity.com/paper/2305.08995/) (2023)
- [Score-based diffusion models for accelerated MRI](https://mlsanity.com/paper/2110.05243/) (2021)
- [Noise2Self: Blind Denoising by Self-Supervision](https://mlsanity.com/paper/1901.11365/) (2019)
- [Plug-and-Play ADMM for Image Restoration: Fixed Point Convergence and Applications](https://mlsanity.com/paper/1605.01710/) (2016)
- [Image reconstruction by domain transform manifold learning](https://mlsanity.com/paper/1704.08841/) (2017)
- [Plug-and-Play Methods Provably Converge with Properly Trained Denoisers](https://mlsanity.com/paper/1905.05406/) (2019)
- [Decomposed Diffusion Sampler for Accelerating Large-Scale Inverse Problems](https://mlsanity.com/paper/2303.05754/) (2023)
- [Noisier2Noise: Learning to Denoise from Unpaired Noisy Data](https://mlsanity.com/paper/1910.11908/) (2019)
- [Noise2Score: Tweedie's Approach to Self-Supervised Image Denoising without Clean Images](https://mlsanity.com/paper/2106.07009/) (2021)
- [Principled Probabilistic Imaging using Diffusion Models as Plug-and-Play Priors](https://mlsanity.com/paper/2405.18782/) (2024)
- [PnP-Flow: Plug-and-Play Image Restoration with Flow Matching](https://mlsanity.com/paper/2410.02423/) (2024)
- [Proximal Denoiser for Convergent Plug-and-Play Optimization with Nonconvex Regularization](https://mlsanity.com/paper/2201.13256/) (2022)
- [Zero-Shot Noise2Noise: Efficient Image Denoising without any Data](https://mlsanity.com/paper/2303.11253/) (2023)
- [DDM2: Self-Supervised Diffusion MRI Denoising with Generative Diffusion Models](https://mlsanity.com/paper/2302.03018/) (2023)
- [Low-Rank Tensor Function Representation for Multi-Dimensional Data Recovery](https://mlsanity.com/paper/2212.00262/) (2022)
- [HIR-Diff: Unsupervised Hyperspectral Image Restoration Via Improved Diffusion Models](https://mlsanity.com/paper/2402.15865/) (2024)
- [DDS2M: Self-Supervised Denoising Diffusion Spatio-Spectral Model for Hyperspectral Image Restoration](https://mlsanity.com/paper/2303.06682/) (2023)
- [Unsupervised Hyperspectral Pansharpening via Low-rank Diffusion Model](https://mlsanity.com/paper/2305.10925/) (2023)
- [Fast Noise Removal in Hyperspectral Images via Representative Coefficient Total Variation](https://mlsanity.com/paper/2211.01825/) (2022)
- [Zero-Shot Image Restoration Using Few-Step Guidance of Consistency Models (and Beyond)](https://mlsanity.com/paper/2412.20596/) (2024)
- [Prior Mismatch and Adaptation in PnP-ADMM with a Nonconvex Convergence Analysis](https://mlsanity.com/paper/2310.00133/) (2023)
- [Decoupling Training-Free Guided Diffusion by ADMM](https://mlsanity.com/paper/2411.12773/) (2024)
- [Score-based Self-supervised MRI Denoising](https://mlsanity.com/paper/2505.05631/) (2025)
- [Self-Supervised Diffusion MRI Denoising via Iterative and Stable Refinement](https://mlsanity.com/paper/2501.13514/) (2025)
- [Band-wise Hyperspectral Image Pansharpening using CNN Model Propagation](https://mlsanity.com/paper/2311.06510/) (2023)

## Abstract (arXiv)

Modern image restoration methods increasingly rely on large-scale supervised training, yet clean targets are often prohibitively difficult to obtain in scientific imaging modalities such as hyperspectral imaging (HSI) and magnetic resonance imaging (MRI). Plug-and-play ADMM (PnP-ADMM) with pretrained diffusion priors offers a promising alternative, but the learned prior distribution can mismatch both the target scientific image distribution and the distribution of ADMM denoiser inputs induced by dual feedback. To mitigate these mismatches, we propose S3-PnP, a self-supervised plug-and-play restoration framework that learns a score prior directly from observation-derived ADMM intermediate states, without clean training targets or externally pretrained weights. Specifically, the learned score corrects the input to the analytical prior update, combining observation-driven corrections with analytical regularization. We further analyze the convergence and reconstruction error of the corrected ADMM algorithm assuming an ideal score and quadratic data fidelity. Experiments on reference-guided HSI restoration, single-image HSI denoising, and MRI denoising demonstrate consistent improvements over competing methods.