# Explicitly Aligned Multi-View Breast Cancer Risk Prediction from Variable-Length Screening Histories

arXiv: https://arxiv.org/abs/2610.16329 · HTML: https://mlsanity.com/paper/2610.16329/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 15 of its 43 references that are in the map.
- First posted on arXiv 12 Oct 2026.

## Builds on (most cited first, 15 of 15)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [PyTorch: An Imperative Style, High-Performance Deep Learning Library](https://mlsanity.com/paper/1912.01703/) (2019)
- [Layer Normalization](https://mlsanity.com/paper/1607.06450/) (2016)
- [Deep Networks with Stochastic Depth](https://mlsanity.com/paper/1603.09382/) (2016)
- [Ground Truth Evaluation of Neural Network Explanations with CLEVR-XAI](https://mlsanity.com/paper/2003.07258/) (2020)
- [Deep Neural Networks Improve Radiologists' Performance in Breast Cancer Screening](https://mlsanity.com/paper/1903.08297/) (2019)
- [Multi-view analysis of unregistered medical images using cross-view transformers](https://mlsanity.com/paper/2103.11390/) (2021)
- [Enhancing Breast Cancer Risk Prediction by Incorporating Prior Images](https://mlsanity.com/paper/2303.15699/) (2023)
- [MV-Swin-T: Mammogram Classification with Multi-view Swin Transformer](https://mlsanity.com/paper/2402.16298/) (2024)
- [Longitudinal Mammogram Risk Prediction](https://mlsanity.com/paper/2404.19083/) (2024)
- [Ordinal Learning: Longitudinal Attention Alignment Model for Predicting Time to Future Breast Cancer Events from Mammograms](https://mlsanity.com/paper/2409.06887/) (2024)
- [Reconsidering Explicit Longitudinal Mammography Alignment for Enhanced Breast Cancer Risk Prediction](https://mlsanity.com/paper/2506.19363/) (2025)
- [RADIFUSION: A multi-radiomics deep learning based breast cancer risk prediction model using sequential mammographic images with image attention and bilateral asymmetry refinement](https://mlsanity.com/paper/2304.00257/) (2023)
- [Breast Cancer Detection from Multi-View Screening Mammograms with Visual Prompt Tuning](https://mlsanity.com/paper/2504.19900/) (2025)
- [Longitudinal Multi-View Breast Cancer Risk Prediction](https://mlsanity.com/paper/2607.11343/) (2026)

## Abstract (arXiv)

Accurate breast cancer risk prediction from screening mammography is essential for improved risk stratification and personalized screening. It can benefit from both temporal breast tissue changes across longitudinal examinations and complementary anatomical information from craniocaudal (CC) and mediolateral oblique (MLO) views. Leveraging longitudinal information requires identifying corresponding tissue regions across examinations, yet most approaches rely on implicit feature alignment without explicitly enforcing spatial consistency. Recent work has demonstrated the benefits of explicit temporal alignment; however, existing methods model each view independently, preventing them from exploiting complementary CC and MLO information. Furthermore, explicit approaches have been limited to a single prior examination. To fill these gaps, we propose (github.com/sot176/FlexLMV-Net), a breast-wise longitudinal multi-view framework that jointly models CC and MLO views across screening examinations while accommodating a variable number of prior examinations. FlexLMV-Net explicitly aligns longitudinal feature maps and integrates complementary views through cross-view temporal fusion and a dual-stream attention block. Evaluated on EMBED and CSAW-CC, FlexLMV-Net consistently outperforms existing approaches across breast density, cancer subtypes, and demographic subgroups, highlighting the benefits of explicit longitudinal alignment, multi-view modeling, and flexible use of available screening history. We further introduce (github.com/sot176/BCRBench), an open-source benchmark that unifies state-of-the-art single- and multi-timepoint breast cancer risk prediction models under standardized preprocessing, training, inference, and evaluation protocols, enabling fair and reproducible comparison of existing methods.