# BigCell: Generating Gigapixel Whole-Slide Images

arXiv: https://arxiv.org/abs/2610.14261 · HTML: https://mlsanity.com/paper/2610.14261/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 38 of its 53 references that are in the map.
- First posted on arXiv 9 Oct 2026.

## Builds on (most cited first, 30 of 38)

- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [Scalable Diffusion Models with Transformers](https://mlsanity.com/paper/2212.09748/) (2022)
- [Classifier-Free Diffusion Guidance](https://mlsanity.com/paper/2207.12598/) (2022)
- [Flow Matching for Generative Modeling](https://mlsanity.com/paper/2210.02747/) (2022)
- [Scaling Rectified Flow Transformers for High-Resolution Image Synthesis](https://mlsanity.com/paper/2403.03206/) (2024)
- [Attention-based Deep Multiple Instance Learning](https://mlsanity.com/paper/1802.04712/) (2018)
- [FLUX.1 Kontext: Flow Matching for In-Context Image Generation and Editing in Latent Space](https://mlsanity.com/paper/2506.15742/) (2025)
- [Stochastic Interpolants: A Unifying Framework for Flows and Diffusions](https://mlsanity.com/paper/2303.08797/) (2023)
- [Data Efficient and Weakly Supervised Computational Pathology on Whole Slide Images](https://mlsanity.com/paper/2004.09666/) (2020)
- [SiT: Exploring Flow and Diffusion-based Generative Models with Scalable Interpolant Transformers](https://mlsanity.com/paper/2401.08740/) (2024)
- [MultiDiffusion: Fusing Diffusion Paths for Controlled Image Generation](https://mlsanity.com/paper/2302.08113/) (2023)
- [MedGemma Technical Report](https://mlsanity.com/paper/2507.05201/) (2025)
- [PixArt-Sigma: Weak-to-Strong Training of Diffusion Transformer for 4K Text-to-Image Generation](https://mlsanity.com/paper/2403.04692/) (2024)
- [REPA-E: Unlocking VAE for End-to-End Tuning with Latent Diffusion Transformers](https://mlsanity.com/paper/2504.10483/) (2025)
- [Multimodal Whole Slide Foundation Model for Pathology](https://mlsanity.com/paper/2411.19666/) (2024)
- [Virchow2: Scaling Self-Supervised Mixed Magnification Models in Pathology](https://mlsanity.com/paper/2408.00738/) (2024)
- [SyncDiffusion: Coherent Montage via Synchronized Joint Diffusions](https://mlsanity.com/paper/2306.05178/) (2023)
- [PRISM: A Multi-Modal Generative Foundation Model for Slide-Level Histopathology](https://mlsanity.com/paper/2405.10254/) (2024)
- [Accelerating Data Processing and Benchmarking of AI Models for Pathology](https://mlsanity.com/paper/2502.06750/) (2025)
- [Diffusion-4K: Ultra-High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2503.18352/) (2025)
- [PathLDM: Text conditioned Latent Diffusion Model for Histopathology](https://mlsanity.com/paper/2309.00748/) (2023)
- [Learned representation-guided diffusion models for large-image generation](https://mlsanity.com/paper/2312.07330/) (2023)
- [FreeScale: Unleashing the Resolution of Diffusion Models via Tuning-Free Scale Fusion](https://mlsanity.com/paper/2412.09626/) (2024)
- [DiffInfinite: Large Mask-Image Synthesis via Parallel Random Patch Diffusion in Histopathology](https://mlsanity.com/paper/2306.13384/) (2023)
- [Importance-Based Token Merging for Efficient Image and Video Generation](https://mlsanity.com/paper/2411.16720/) (2024)
- [ZoomLDM: Latent Diffusion Model for multi-scale image generation](https://mlsanity.com/paper/2411.16969/) (2024)
- [Diffusion-based generation of Histopathological Whole Slide Images at a Gigapixel scale](https://mlsanity.com/paper/2311.08199/) (2023)
- [Fast constrained sampling in pre-trained diffusion models](https://mlsanity.com/paper/2410.18804/) (2024)
- [PathDiff: Histopathology Image Synthesis with Unpaired Text and Mask Conditions](https://mlsanity.com/paper/2506.23440/) (2025)
- [TICON: A Slide-Level Tile Contextualizer for Histopathology Representation Learning](https://mlsanity.com/paper/2512.21331/) (2025)

## Abstract (arXiv)

Whole-slide images (WSIs) are gigapixel-scale digital scans of histopathology tissue and serve as the primary basis for cancer diagnosis. Existing histopathology generative models operate at the patch scale, producing fixed-size tiles of at most 1024×1024 pixels which encompass only a small fraction of the WSI. In contrast, text reports for clinical diagnoses and slide-level diagnostic labels -- the supervision that exists at scale -- operate at the whole-slide level. We present BigCell, the first approach to generate coherent whole-slide histopathology images at native gigapixel resolution. BigCell trains a flow-matching transformer at 2048×2048 pixels on over 120,000 publicly available WSIs spanning multiple organ types. Conditioning on embeddings from pathology foundation models and using an inference-time sliding-window pipeline, BigCell generates coherent images of up to 32,768×32,768 pixels, outperforming prior tile generators on both tile-level and slide-level fidelity metrics. To make gigapixel synthesis practical, we introduce an adaptive scheduling strategy that prioritizes important slide regions, speeding up image generation by over 3ttimes with minimal quality degradation. Furthermore, we propose the first text-to-image synthesis at 8k resolution by training a separate model that produces dense conditioning grids directly from pathology text reports. We demonstrate that augmenting with synthetic samples improves slide-level few-shot classification performance by up to 18 % over baselines trained on real data.