# Temporal Diffusion Bridge Model for Vessel Extraction Using Physics-informed Synthetic Data

arXiv: https://arxiv.org/abs/2610.14105 · HTML: https://mlsanity.com/paper/2610.14105/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 13 of its 51 references that are in the map.
- First posted on arXiv 8 Oct 2026.

## Builds on (most cited first, 13 of 13)

- [mixup: Beyond Empirical Risk Minimization](https://mlsanity.com/paper/1710.09412/) (2017)
- [Image-to-Image Translation with Conditional Adversarial Networks](https://mlsanity.com/paper/1611.07004/) (2016)
- [Medical Image Synthesis for Data Augmentation and Anonymization using Generative Adversarial Networks](https://mlsanity.com/paper/1807.10225/) (2018)
- [Tensor Robust Principal Component Analysis with A New Tensor Nuclear Norm](https://mlsanity.com/paper/1804.03728/) (2018)
- [Fast Auto-Differentiable Digitally Reconstructed Radiographs for Solving Inverse Problems in Intraoperative Imaging](https://mlsanity.com/paper/2208.12737/) (2022)
- [Learning General-Purpose Biomedical Volume Representations using Randomized Synthesis](https://mlsanity.com/paper/2411.02372/) (2024)
- [Noise-Consistent Siamese-Diffusion for Medical Image Synthesis and Segmentation](https://mlsanity.com/paper/2505.06068/) (2025)
- [Synthetic optical coherence tomography angiographs for detailed retinal vessel segmentation without human annotations](https://mlsanity.com/paper/2306.10941/) (2023)
- [Sequential vessel segmentation via deep channel attention network](https://mlsanity.com/paper/2102.05229/) (2021)
- [AnyStar: Domain randomized universal star-convex 3D instance segmentation](https://mlsanity.com/paper/2307.07044/) (2023)
- [Robust PCA Unrolling Network for Super-resolution Vessel Extraction in X-ray Coronary Angiography](https://mlsanity.com/paper/2204.08466/) (2022)
- [Robust Implementation of Foreground Extraction and Vessel Segmentation for X-ray Coronary Angiography Image Sequence](https://mlsanity.com/paper/2209.07237/) (2022)
- [Generative Data-engine Foundation Model for Universal Few-shot 2D Vascular Image Segmentation](https://mlsanity.com/paper/2604.10737/) (2026)

## Abstract (arXiv)

Accurate artery extraction from X-ray coronary angiography (XCA) is essential for coronary artery disease diagnosis and intervention. However, low vessel visibility, respiratory and cardiac motion, and limited annotations challenge existing methods. Moreover, most deep learning approaches produce binary vessel masks without preserving clinically relevant intra-arterial contrast information. We propose a Temporal Diffusion Bridge Model (TDBM) that formulates vessel extraction as image translation and learns from physics-informed synthetic data without manual vessel annotations. A physics-based XCA synthesis engine generates diverse, perfectly aligned pairs of contrast-enhanced and contrast-free images. Using these pairs, TDBM learns cross-domain mappings to recover high-fidelity vessel information. Temporal conditioning incorporates adjacent frames to improve consistency, while a vessel-aware contrastive loss exploits background-invariant synthetic pairs to enhance vascular discrimination. We evaluate TDBM on two XCA vessel segmentation datasets and conduct a reader study using two real-patient XCA sequence datasets. Zero-shot segmentation is further assessed on retinal imaging and fluorescence microscopy datasets. Results demonstrate that TDBM consistently outperforms existing methods and generalizes effectively across imaging modalities. Code and trained weights will be available at: https://github.com/Advanced-AI-in-Medicine-and-Physics-Lab/TDBM