# Scaling Multi-Teacher Distillation for Digital Pathology

arXiv: https://arxiv.org/abs/2610.12574 · HTML: https://mlsanity.com/paper/2610.12574/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 56 of its 75 references that are in the map.
- First posted on arXiv 8 Oct 2026.

## Builds on (most cited first, 30 of 56)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [Distilling the Knowledge in a Neural Network](https://mlsanity.com/paper/1503.02531/) (2015)
- [DINOv2: Learning Robust Visual Features without Supervision](https://mlsanity.com/paper/2304.07193/) (2023)
- [Representation Learning with Contrastive Predictive Coding](https://mlsanity.com/paper/1807.03748/) (2018)
- [Emerging Properties in Self-Supervised Vision Transformers](https://mlsanity.com/paper/2104.14294/) (2021)
- [BLIP-2: Bootstrapping Language-Image Pre-training with Frozen Image Encoders and Large Language Models](https://mlsanity.com/paper/2301.12597/) (2023)
- [Flamingo: a Visual Language Model for Few-Shot Learning](https://mlsanity.com/paper/2204.14198/) (2022)
- [Outrageously Large Neural Networks: The Sparsely-Gated Mixture-of-Experts Layer](https://mlsanity.com/paper/1701.06538/) (2017)
- [Switch Transformers: Scaling to Trillion Parameter Models with Simple and Efficient Sparsity](https://mlsanity.com/paper/2101.03961/) (2021)
- [OpenVLA: An Open-Source Vision-Language-Action Model](https://mlsanity.com/paper/2406.09246/) (2024)
- [Mixtral of Experts](https://mlsanity.com/paper/2401.04088/) (2024)
- [Visual Prompt Tuning](https://mlsanity.com/paper/2203.12119/) (2022)
- [LXMERT: Learning Cross-Modality Encoder Representations from Transformers](https://mlsanity.com/paper/1908.07490/) (2019)
- [WILDS: A Benchmark of in-the-Wild Distribution Shifts](https://mlsanity.com/paper/2012.07421/) (2020)
- [CoCa: Contrastive Captioners are Image-Text Foundation Models](https://mlsanity.com/paper/2205.01917/) (2022)
- [Gradient Surgery for Multi-Task Learning](https://mlsanity.com/paper/2001.06782/) (2020)
- [Attention-based Deep Multiple Instance Learning](https://mlsanity.com/paper/1802.04712/) (2018)
- [Rotation Equivariant CNNs for Digital Pathology](https://mlsanity.com/paper/1806.03962/) (2018)
- [Prompt-aligned Gradient for Prompt Tuning](https://mlsanity.com/paper/2205.14865/) (2022)
- [Quilt-1M: One Million Image-Text Pairs for Histopathology](https://mlsanity.com/paper/2306.11207/) (2023)
- [AM-RADIO: Agglomerative Vision Foundation Model -- Reduce All Domains Into One](https://mlsanity.com/paper/2312.06709/) (2023)
- [Multimodal Whole Slide Foundation Model for Pathology](https://mlsanity.com/paper/2411.19666/) (2024)
- [Virchow2: Scaling Self-Supervised Mixed Magnification Models in Pathology](https://mlsanity.com/paper/2408.00738/) (2024)
- [Benchmarking Self-Supervised Learning on Diverse Pathology Datasets](https://mlsanity.com/paper/2212.04690/) (2022)
- [SEED: Self-supervised Distillation For Visual Representation](https://mlsanity.com/paper/2101.04731/) (2021)
- [BRACS: A Dataset for BReAst Carcinoma Subtyping in H&E Histology Images](https://mlsanity.com/paper/2111.04740/) (2021)
- [HEST-1k: A Dataset for Spatial Transcriptomics and Histology Image Analysis](https://mlsanity.com/paper/2406.16192/) (2024)
- [PRISM: A Multi-Modal Generative Foundation Model for Slide-Level Histopathology](https://mlsanity.com/paper/2405.10254/) (2024)

## Abstract (arXiv)

Multi-teacher distillation allows transferring knowledge from multiple "teacher" networks to a single "student" network. This method is promising in fields such as digital pathology, where many powerful foundation models were proposed recently. However, as we show in this paper, the standard multi-teacher distillation approach reacts poorly to an increase in the number of teachers used to train a student encoder. We demonstrate that learning teacher-specific representations is a key to scaling in MTD. Importantly, different design choices, such as learnable teacher tokens, a tailored attention scheme, additional mixture-of-experts layers and a contrastive loss, are proposed to better learn such teacher-specific representations. We show that our method better scales with respect to the number of considered teachers, allowing us to train compact student encoders, up to 10x more efficient than larger teacher foundation models, while matching their performance and even outperforming them on a large set of tile-level and slide-level tasks. We conduct a thorough empirical validation, evaluating more than 10 foundation models on 39 tasks spanning tile and slide levels. As a result, we release a new collection of strong and efficient foundation models, named OMNI, trained from the knowledge of 10 state-of-the-art foundation models. We finally conduct an analysis of the learned teacher-specific representations, highlighting their complementarity and explaining why they can be easily aggregated at downstream time.