# SAIL: Scientific Agentic Intelligence via a Science-Aware Loop

arXiv: https://arxiv.org/abs/2610.11451 · HTML: https://mlsanity.com/paper/2610.11451/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Web, search, and research agents, one of 16 directions in LLM agents and tool use.
- Builds on 6 of its 27 references that are in the map.
- First posted on arXiv 8 Oct 2026.

## Placed in

- LLM agents and tool use / [Web, search, and research agents](https://mlsanity.com/agents/web-search-and-research-agents/)

## Builds on (most cited first, 6 of 6)

- [AlphaEvolve: A coding agent for scientific and algorithmic discovery](https://mlsanity.com/paper/2506.13131/) (2025)
- [SciCode: A Research Coding Benchmark Curated by Scientists](https://mlsanity.com/paper/2407.13168/) (2024)
- [Kosmos: An AI Scientist for Autonomous Discovery](https://mlsanity.com/paper/2511.02824/) (2025)
- [MOPD: Multi-Teacher On-Policy Distillation for Capability Integration in LLM Post-Training](https://mlsanity.com/paper/2606.30406/) (2026)
- [DeepResearch Bench II: Diagnosing Deep Research Agents via Rubrics from Expert Reports](https://mlsanity.com/paper/2601.08536/) (2026)
- [Scaling the Horizon, Not the Parameters: Reaching Trillion-Parameter Performance with a 35B Agent](https://mlsanity.com/paper/2606.30616/) (2026)

## Abstract (arXiv)

We introduce SAIL, an open model with 35B total and 3B active parameters for literature research, scientific coding, and multi-step research workflows. SAIL is developed through a science-aware improvement loop: agents built on frontier AI models analyze its task failures and construct training tasks that address the underlying capability gaps. The diagnosis examines search and evidence selection in literature tasks, scientific assumptions and reasoning in coding, and planning and revision in longer investigations. The agents draw on paper collections and scientific code repositories to build problems, interaction trajectories, and executable tasks with the required environments and tools. We repeat this loop over multiple development cycles and train SAIL through supervised fine-tuning, specialist training, multi-teacher on-policy distillation, and agentic reinforcement learning. SAIL achieves competitive performance across scientific research tasks with substantially fewer parameters than leading open-weight models.