# On Impact of Loss Function on the Performance of Neural Networks in Melanoma Diagnosis

arXiv: https://arxiv.org/abs/2610.06139 · HTML: https://mlsanity.com/paper/2610.06139/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 9 of its 21 references that are in the map.
- First posted on arXiv 5 Oct 2026.

## Builds on (most cited first, 9 of 9)

- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [EfficientNet: Rethinking Model Scaling for Convolutional Neural Networks](https://mlsanity.com/paper/1905.11946/) (2019)
- [On Calibration of Modern Neural Networks](https://mlsanity.com/paper/1706.04599/) (2017)
- [Class-Balanced Loss Based on Effective Number of Samples](https://mlsanity.com/paper/1901.05555/) (2019)
- [EfficientNetV2: Smaller Models and Faster Training](https://mlsanity.com/paper/2104.00298/) (2021)
- [Learning Imbalanced Datasets with Label-Distribution-Aware Margin Loss](https://mlsanity.com/paper/1906.07413/) (2019)
- [Long-tail learning via logit adjustment](https://mlsanity.com/paper/2007.07314/) (2020)
- [Balanced Meta-Softmax for Long-Tailed Visual Recognition](https://mlsanity.com/paper/2007.10740/) (2020)
- [LMFLOSS: A Hybrid Loss For Imbalanced Medical Image Classification](https://mlsanity.com/paper/2212.12741/) (2022)

## Abstract (arXiv)

Melanoma is the deadliest type of skin cancer, whose early diagnosis is crucial for patients' survival. Image classification using deep learning models has shown promising results for melanoma diagnosis. However, the performance of these models on the melanoma datasets such as SIIM-ISIC melanoma classification dataset is a challenge due to the class imbalance. One of the methods to deal with this challenge is using loss function modifications. In this work, we have investigated the effect of different loss functions on the performance of deep neural networks. We trained these networks using focal loss, logit-adjusted softmax cross-entropy (CE) loss, and weighted softmax CE loss, and we report different metrics for evaluating performance and uncertainty calibration. Our results suggest that focal loss delivers a good combination of performance in terms of AUC and uncertainty calibration in terms of expected calibration error (ECE) simultaneously.