# HuatuoGPT-3: RL-Only Domain Adaptation from Base Models

arXiv: https://arxiv.org/abs/2610.05966 · HTML: https://mlsanity.com/paper/2610.05966/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 71 of its 94 references that are in the map.
- First posted on arXiv 5 Oct 2026.

## Builds on (most cited first, 30 of 71)

- [Training language models to follow instructions with human feedback](https://mlsanity.com/paper/2203.02155/) (2022)
- [Training Verifiers to Solve Math Word Problems](https://mlsanity.com/paper/2110.14168/) (2021)
- [DeepSeekMath: Pushing the Limits of Mathematical Reasoning in Open Language Models](https://mlsanity.com/paper/2402.03300/) (2024)
- [Qwen3 Technical Report](https://mlsanity.com/paper/2505.09388/) (2025)
- [Deep reinforcement learning from human preferences](https://mlsanity.com/paper/1706.03741/) (2017)
- [DAPO: An Open-Source LLM Reinforcement Learning System at Scale](https://mlsanity.com/paper/2503.14476/) (2025)
- [Learning to summarize from human feedback](https://mlsanity.com/paper/2009.01325/) (2020)
- [MMLU-Pro: A More Robust and Challenging Multi-Task Language Understanding Benchmark](https://mlsanity.com/paper/2406.01574/) (2024)
- [What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Exams](https://mlsanity.com/paper/2009.13081/) (2020)
- [Instruction-Following Evaluation for Large Language Models](https://mlsanity.com/paper/2311.07911/) (2023)
- [Tulu 3: Pushing Frontiers in Open Language Model Post-Training](https://mlsanity.com/paper/2411.15124/) (2024)
- [Group Sequence Policy Optimization](https://mlsanity.com/paper/2507.18071/) (2025)
- [DeepSeek-V3.2: Pushing the Frontier of Open Large Language Models](https://mlsanity.com/paper/2512.02556/) (2025)
- [Mastering Chess and Shogi by Self-Play with a General Reinforcement Learning Algorithm](https://mlsanity.com/paper/1712.01815/) (2017)
- [An Empirical Investigation of Catastrophic Forgetting in Gradient-Based Neural Networks](https://mlsanity.com/paper/1312.6211/) (2013)
- [MedMCQA : A Large-scale Multi-Subject Multi-Choice Dataset for Medical domain Question Answering](https://mlsanity.com/paper/2203.14371/) (2022)
- [SimpleRL-Zoo: Investigating and Taming Zero Reinforcement Learning for Open Base Models in the Wild](https://mlsanity.com/paper/2503.18892/) (2025)
- [Open-Reasoner-Zero: An Open Source Approach to Scaling Up Reinforcement Learning on the Base Model](https://mlsanity.com/paper/2503.24290/) (2025)
- [HealthBench: Evaluating Large Language Models Towards Improved Human Health](https://mlsanity.com/paper/2505.08775/) (2025)
- [Towards Expert-Level Medical Question Answering with Large Language Models](https://mlsanity.com/paper/2305.09617/) (2023)
- [Rubrics as Rewards: Reinforcement Learning Beyond Verifiable Domains](https://mlsanity.com/paper/2507.17746/) (2025)
- [CodeRL: Mastering Code Generation through Pretrained Models and Deep Reinforcement Learning](https://mlsanity.com/paper/2207.01780/) (2022)
- [ChatDoctor: A Medical Chat Model Fine-Tuned on a Large Language Model Meta-AI (LLaMA) Using Medical Domain Knowledge](https://mlsanity.com/paper/2303.14070/) (2023)
- [MedAlpaca -- An Open-Source Collection of Medical Conversational AI Models and Training Data](https://mlsanity.com/paper/2304.08247/) (2023)
- [Learning to Reason under Off-Policy Guidance](https://mlsanity.com/paper/2504.14945/) (2025)
- [HuatuoGPT-o1, Towards Medical Complex Reasoning with LLMs](https://mlsanity.com/paper/2412.18925/) (2024)
- [Lingshu: A Generalist Foundation Model for Unified Multimodal Medical Understanding and Reasoning](https://mlsanity.com/paper/2506.07044/) (2025)
- [MedXpertQA: Benchmarking Expert-Level Medical Reasoning and Understanding](https://mlsanity.com/paper/2501.18362/) (2025)
- [HuatuoGPT, towards Taming Language Model to Be a Doctor](https://mlsanity.com/paper/2305.15075/) (2023)
- [ReMax: A Simple, Effective, and Efficient Reinforcement Learning Method for Aligning Large Language Models](https://mlsanity.com/paper/2310.10505/) (2023)

## Abstract (arXiv)

Domain adaptation aims to turn a general-purpose large language model (LLM) into an expert for a target domain. While the dominant SFT+RL pipeline offers a convenient cold start, it may reduce exploration diversity and introduces additional complexity through multi-stage optimization. These limitations motivate RL-only adaptation. However, pure on-policy RL suffers from a cold-start problem, while mixed-policy RL still falls short: informative tokens in teacher outputs are learned too slowly in early training, and stale teacher outputs can hinder later improvement. We identify these two failure modes as Gradient Starvation and Teacher-Distribution Anchoring. To address them, we propose One-stage Policy Optimization (OnePO), which treats teacher outputs as transient guidance for policy improvement. OnePO combines Adaptive Objective Evolution to strengthen learning on informative low-probability teacher tokens and Teacher Retirement to discard teacher outputs once the current policy can surpass them. On medical adaptation, OnePO achieves 67.2 on HealthBench (Total) with only 20K training samples, outperforming SFT+RL and pure RL by 2.7 and 7.4 points, respectively. We further scale OnePO to produce HuatuoGPT-3, an open-source medical LLM series whose 27B variant reaches 70.1 on HealthBench (Total) and 71.4 on HealthBench Professional, surpassing frontier models such as GPT-6 Astra. Models and code are available at https://github.com/FreedomIntelligence/HuatuoGPT-3.