# SEIS: Self-Evolving Inference Systems

arXiv: https://arxiv.org/abs/2610.04646 · HTML: https://mlsanity.com/paper/2610.04646/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Self-evolving LLM agents, one of 13 directions in Synthetic data and self-improvement for LLMs.
- Builds on 32 of its 41 references that are in the map.
- First posted on arXiv 3 Oct 2026.

## Placed in

- Synthetic data and self-improvement for LLMs / [Self-evolving LLM agents](https://mlsanity.com/synth/self-evolving-llm-agents/)

## Builds on (most cited first, 30 of 32)

- [Training Verifiers to Solve Math Word Problems](https://mlsanity.com/paper/2110.14168/) (2021)
- [Efficient Memory Management for Large Language Model Serving with PagedAttention](https://mlsanity.com/paper/2309.06180/) (2023)
- [Reflexion: Language Agents with Verbal Reinforcement Learning](https://mlsanity.com/paper/2303.11366/) (2023)
- [FlashAttention: Fast and Memory-Efficient Exact Attention with IO-Awareness](https://mlsanity.com/paper/2205.14135/) (2022)
- [SWE-bench: Can Language Models Resolve Real-World GitHub Issues?](https://mlsanity.com/paper/2310.06770/) (2023)
- [Pointer Sentinel Mixture Models](https://mlsanity.com/paper/1609.07843/) (2016)
- [Voyager: An Open-Ended Embodied Agent with Large Language Models](https://mlsanity.com/paper/2305.16291/) (2023)
- [GPTQ: Accurate Post-Training Quantization for Generative Pre-trained Transformers](https://mlsanity.com/paper/2210.17323/) (2022)
- [Fast Inference from Transformers via Speculative Decoding](https://mlsanity.com/paper/2211.17192/) (2022)
- [AWQ: Activation-aware Weight Quantization for LLM Compression and Acceleration](https://mlsanity.com/paper/2306.00978/) (2023)
- [SGLang: Efficient Execution of Structured Language Model Programs](https://mlsanity.com/paper/2312.07104/) (2023)
- [The AI Scientist: Towards Fully Automated Open-Ended Scientific Discovery](https://mlsanity.com/paper/2408.06292/) (2024)
- [Accelerating Large Language Model Decoding with Speculative Sampling](https://mlsanity.com/paper/2302.01318/) (2023)
- [LLM.int8(): 8-bit Matrix Multiplication for Transformers at Scale](https://mlsanity.com/paper/2208.07339/) (2022)
- [ExpeL: LLM Agents Are Experiential Learners](https://mlsanity.com/paper/2308.10144/) (2023)
- [AlphaEvolve: A coding agent for scientific and algorithmic discovery](https://mlsanity.com/paper/2506.13131/) (2025)
- [Medusa: Simple LLM Inference Acceleration Framework with Multiple Decoding Heads](https://mlsanity.com/paper/2401.10774/) (2024)
- [Terminal-Bench: Benchmarking Agents on Hard, Realistic Tasks in Command Line Interfaces](https://mlsanity.com/paper/2601.11868/) (2026)
- [EAGLE: Speculative Sampling Requires Rethinking Feature Uncertainty](https://mlsanity.com/paper/2401.15077/) (2024)
- [MLE-bench: Evaluating Machine Learning Agents on Machine Learning Engineering](https://mlsanity.com/paper/2410.07095/) (2024)
- [Monitoring Reasoning Models for Misbehavior and the Risks of Promoting Obfuscation](https://mlsanity.com/paper/2503.11926/) (2025)
- [Darwin Godel Machine: Open-Ended Evolution of Self-Improving Agents](https://mlsanity.com/paper/2505.22954/) (2025)
- [PaperBench: Evaluating AI's Ability to Replicate AI Research](https://mlsanity.com/paper/2504.01848/) (2025)
- [Break the Sequential Dependency of LLM Inference Using Lookahead Decoding](https://mlsanity.com/paper/2402.02057/) (2024)
- [FlashInfer: Efficient and Customizable Attention Engine for LLM Inference Serving](https://mlsanity.com/paper/2501.01005/) (2025)
- [KernelBench: Can LLMs Write Efficient GPU Kernels?](https://mlsanity.com/paper/2502.10517/) (2025)
- [Defining and Characterizing Reward Hacking](https://mlsanity.com/paper/2209.13085/) (2022)
- [RE-Bench: Evaluating frontier AI R&D capabilities of language model agents against human experts](https://mlsanity.com/paper/2411.15114/) (2024)
- [Self-Taught Optimizer (STOP): Recursively Self-Improving Code Generation](https://mlsanity.com/paper/2310.02304/) (2023)
- [ImpossibleBench: Measuring LLMs' Propensity of Exploiting Test Cases](https://mlsanity.com/paper/2510.20270/) (2025)

## Abstract (arXiv)

Inference systems determine how fast and how cheaply language models can be served, so making them faster has direct practical value. However, prior work focuses mostly on optimizing certain parts such as kernels or memory within the large system. In this work, we take a holistic approach and apply agentic self-evolution to optimize the whole system end-to-end. Our SEIS (Self-Evolving Inference Systems) autonomously optimizes the entire mini-sglang engine without human intervention through iterative sessions with inherited experiences and code changes. Serving Qwen3-0.6B on H100, the resulting engine reaches 3.27X the throughput of the original mini-sglang implementation and beats SOTA engines like vLLM, TensorRT-LLM, and SGLang in the single-request workload. The correctness of the optimized inference engine by SEIS is tested in terms of numerical difference and downstream accuracy on math and long-context retrieval tasks. The code and session histories show that the speedup comes from redesigning the whole engine and that building on earlier sessions beats independent attempts. These results suggest that agentic self-evolution can optimize a complex system end-to-end. The evaluation also has to evolve with the engine, and letting agents evolve it is a natural next step.