# LabBook: Harnessing Experimental History for Efficient LLM-Driven Discovery

arXiv: https://arxiv.org/abs/2610.00675 · HTML: https://mlsanity.com/paper/2610.00675/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 23 of its 32 references that are in the map.
- First posted on arXiv 30 Sep 2026.

## Builds on (most cited first, 23 of 23)

- [Reflexion: Language Agents with Verbal Reinforcement Learning](https://mlsanity.com/paper/2303.11366/) (2023)
- [Generative Agents: Interactive Simulacra of Human Behavior](https://mlsanity.com/paper/2304.03442/) (2023)
- [Lost in the Middle: How Language Models Use Long Contexts](https://mlsanity.com/paper/2307.03172/) (2023)
- [MemGPT: Towards LLMs as Operating Systems](https://mlsanity.com/paper/2310.08560/) (2023)
- [DeepSeek-V4: Towards Highly Efficient Million-Token Context Intelligence](https://mlsanity.com/paper/2606.19348/) (2026)
- [ExpeL: LLM Agents Are Experiential Learners](https://mlsanity.com/paper/2308.10144/) (2023)
- [AlphaEvolve: A coding agent for scientific and algorithmic discovery](https://mlsanity.com/paper/2506.13131/) (2025)
- [Large Language Models as Optimizers](https://mlsanity.com/paper/2309.03409/) (2023)
- [Darwin Godel Machine: Open-Ended Evolution of Self-Improving Agents](https://mlsanity.com/paper/2505.22954/) (2025)
- [ReasoningBank: Scaling Agent Self-Evolving with Reasoning Memory](https://mlsanity.com/paper/2509.25140/) (2025)
- [ReEvo: Large Language Models as Hyper-Heuristics with Reflective Evolution](https://mlsanity.com/paper/2402.01145/) (2024)
- [Evolution of Heuristics: Towards Efficient Automatic Algorithm Design Using Large Language Model](https://mlsanity.com/paper/2401.02051/) (2024)
- [ShinkaEvolve: Towards Open-Ended And Sample-Efficient Program Evolution](https://mlsanity.com/paper/2509.19349/) (2025)
- [AdaEvolve: Adaptive LLM Driven Zeroth-Order Optimization](https://mlsanity.com/paper/2602.20133/) (2026)
- [EvoX: Meta-Evolution for Automated Discovery](https://mlsanity.com/paper/2602.23413/) (2026)
- [Barbarians at the Gate: How AI is Upending Systems Research](https://mlsanity.com/paper/2510.06189/) (2025)
- [CodeEvolve: an open source evolutionary coding agent for algorithmic discovery and optimization](https://mlsanity.com/paper/2510.14150/) (2025)
- [DeltaEvolve: Accelerating Scientific Discovery through Momentum-Driven Evolution](https://mlsanity.com/paper/2602.02919/) (2026)
- [FrontierCS: Evolving Challenges for Evolving Intelligence](https://mlsanity.com/paper/2512.15699/) (2025)
- [HeuriGym: An Agentic Benchmark for LLM-Crafted Heuristics in Combinatorial Optimization](https://mlsanity.com/paper/2506.07972/) (2025)
- [Dream-RSI: Recursive Self-Improvement through Evolving Worlds](https://mlsanity.com/paper/2609.14858/) (2026)
- [CausalEvolve: Towards Open-Ended Discovery with Causal Scratchpad](https://mlsanity.com/paper/2603.14575/) (2026)
- [RefineEvo: Planning-Guided Heuristic Evolution with Bidirectional Experience](https://mlsanity.com/paper/2607.11358/) (2026)

## Abstract (arXiv)

Evolutionary approaches to LLM-driven discovery often generate new programs from a small set of selected ancestors. This keeps contexts manageable but can omit useful evidence from other experiments, whereas including the full experimental history produces long, redundant contexts. We introduce a simple, single-agent discovery harness built around LabBook, an agent-maintained memory that serves two complementary roles: guiding retrieval of relevant evidence from a complete experimental log and informing the generation of new solutions. At each iteration, the same agent combines its memory with retrieved evidence and jointly produces the next program and an updated LabBook. This separates complete history retention from selective context construction, without requiring an explicit population or branching search structure. On 49 Frontier-CS problems, LabBook improves the observed quality-cost trade-off over the evaluated evolutionary baselines with two backbones, while remaining competitive across nine additional mathematical, systems, and heuristic-design tasks. Code will be released at https://github.com/BoYuanVisionary/LabBook.