# MedKIT: Evaluating Knowledge Integration and Generalization in Large Language Models

arXiv: https://arxiv.org/abs/2609.38543 · HTML: https://mlsanity.com/paper/2609.38543/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 42 of its 56 references that are in the map.
- First posted on arXiv 29 Sep 2026.

## Builds on (most cited first, 30 of 42)

- [LoRA: Low-Rank Adaptation of Large Language Models](https://mlsanity.com/paper/2106.09685/) (2021)
- [DeepSeekMath: Pushing the Limits of Mathematical Reasoning in Open Language Models](https://mlsanity.com/paper/2402.03300/) (2024)
- [Retrieval-Augmented Generation for Knowledge-Intensive NLP Tasks](https://mlsanity.com/paper/2005.11401/) (2020)
- [ReAct: Synergizing Reasoning and Acting in Language Models](https://mlsanity.com/paper/2210.03629/) (2022)
- [Direct Preference Optimization: Your Language Model is Secretly a Reward Model](https://mlsanity.com/paper/2305.18290/) (2023)
- [Dense Passage Retrieval for Open-Domain Question Answering](https://mlsanity.com/paper/2004.04906/) (2020)
- [Locating and Editing Factual Associations in GPT](https://mlsanity.com/paper/2202.05262/) (2022)
- [Billion-scale similarity search with GPUs](https://mlsanity.com/paper/1702.08734/) (2017)
- [REALM: Retrieval-Augmented Language Model Pre-Training](https://mlsanity.com/paper/2002.08909/) (2020)
- [Improving language models by retrieving from trillions of tokens](https://mlsanity.com/paper/2112.04426/) (2021)
- [Mass-Editing Memory in a Transformer](https://mlsanity.com/paper/2210.07229/) (2022)
- [Efficient and robust approximate nearest neighbor search using Hierarchical Navigable Small World graphs](https://mlsanity.com/paper/1603.09320/) (2016)
- [Robust fine-tuning of zero-shot models](https://mlsanity.com/paper/2109.01903/) (2021)
- [Fast Model Editing at Scale](https://mlsanity.com/paper/2110.11309/) (2021)
- [Memory-Based Model Editing at Scale](https://mlsanity.com/paper/2206.06520/) (2022)
- [Zero-Shot Relation Extraction via Reading Comprehension](https://mlsanity.com/paper/1706.04115/) (2017)
- [Orthogonal Subspace Learning for Language Model Continual Learning](https://mlsanity.com/paper/2310.14152/) (2023)
- [MQuAKE: Assessing Knowledge Editing in Language Models via Multi-Hop Questions](https://mlsanity.com/paper/2305.14795/) (2023)
- [Can We Edit Factual Knowledge by In-Context Learning?](https://mlsanity.com/paper/2305.12740/) (2023)
- [Aging with GRACE: Lifelong Model Editing with Discrete Key-Value Adaptors](https://mlsanity.com/paper/2211.11031/) (2022)
- [AlphaEdit: Null-Space Constrained Knowledge Editing for Language Models](https://mlsanity.com/paper/2410.02355/) (2024)
- [Patching open-vocabulary models by interpolating weights](https://mlsanity.com/paper/2208.05592/) (2022)
- [WARM: On the Benefits of Weight Averaged Reward Models](https://mlsanity.com/paper/2401.12187/) (2024)
- [State-of-the-art generalisation research in NLP: A taxonomy and review](https://mlsanity.com/paper/2210.03050/) (2022)
- [Model Editing at Scale leads to Gradual and Catastrophic Forgetting](https://mlsanity.com/paper/2401.07453/) (2024)
- [WISE: Rethinking the Knowledge Memory for Lifelong Model Editing of Large Language Models](https://mlsanity.com/paper/2405.14768/) (2024)
- [The Butterfly Effect of Model Editing: Few Edits Can Trigger Large Language Models Collapse](https://mlsanity.com/paper/2402.09656/) (2024)
- [RECALL: A Benchmark for LLMs Robustness against External Counterfactual Knowledge](https://mlsanity.com/paper/2311.08147/) (2023)
- [WikiBigEdit: Understanding the Limits of Lifelong Knowledge Editing in LLMs](https://mlsanity.com/paper/2503.05683/) (2025)
- [SEEKR: Selective Attention-Guided Knowledge Retention for Continual Learning of Large Language Models](https://mlsanity.com/paper/2411.06171/) (2024)

## Abstract (arXiv)

Constantly evolving real-world knowledge necessitates models to be updated continuously. Especially in medicine, as clinical evidence changes over time, outdated knowledge can pose safety risks. Existing evaluations of knowledge integration focus on factual recall, offering limited insight into whether newly integrated knowledge is actually usable. Our benchmark MedKIT (Medical Knowledge Integration and Transfer) provides a granular evaluation of how models integrate and apply knowledge under realistic sequences of clinical updates. Each instance corresponds to a factual update derived from clinical evidence, paired with targeted probes that assess transfer across lexical variation, relational transformations, compositional reasoning, and open-ended operationalization, as well as locality tests for knowledge preservation. Using MedKIT, we conduct a large-scale empirical study of 12 knowledge integration strategies across 5 diverse models, including both general-purpose and medical LLMs. Our results reveal a consistent gap between recall and usable knowledge: while most methods achieve strong gains on the original update task and under lexical variation, relational generalization is limited, and no method yields meaningful improvements on compositional or operational tasks. These findings highlight a fundamental challenge in knowledge integration and position MedKIT as a testbed for developing methods that make newly integrated knowledge more consistently usable across tasks and contexts.