# Generative AI-Based Data Augmentation for Oral Lesion Classification: The PhotoMOCI Dataset and Benchmark

arXiv: https://arxiv.org/abs/2609.35226 · HTML: https://mlsanity.com/paper/2609.35226/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 38 of its 92 references that are in the map.
- First posted on arXiv 28 Sep 2026.

## Builds on (most cited first, 30 of 38)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Adam: A Method for Stochastic Optimization](https://mlsanity.com/paper/1412.6980/) (2014)
- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [Microsoft COCO: Common Objects in Context](https://mlsanity.com/paper/1405.0312/) (2014)
- [LoRA: Low-Rank Adaptation of Large Language Models](https://mlsanity.com/paper/2106.09685/) (2021)
- [Diffusion Models Beat GANs on Image Synthesis](https://mlsanity.com/paper/2105.05233/) (2021)
- [Deep Unsupervised Learning using Nonequilibrium Thermodynamics](https://mlsanity.com/paper/1503.03585/) (2015)
- [A Style-Based Generator Architecture for Generative Adversarial Networks](https://mlsanity.com/paper/1812.04948/) (2018)
- [Generative Adversarial Networks](https://mlsanity.com/paper/2203.00667/) (2022)
- [Analyzing and Improving the Image Quality of StyleGAN](https://mlsanity.com/paper/1912.04958/) (2019)
- [Conditional Generative Adversarial Nets](https://mlsanity.com/paper/1411.1784/) (2014)
- [Unsupervised Representation Learning with Deep Convolutional Generative Adversarial Networks](https://mlsanity.com/paper/1511.06434/) (2015)
- [Demystifying MMD GANs](https://mlsanity.com/paper/1801.01401/) (2018)
- [Alias-Free Generative Adversarial Networks](https://mlsanity.com/paper/2106.12423/) (2021)
- [Improved Precision and Recall Metric for Assessing Generative Models](https://mlsanity.com/paper/1904.06991/) (2019)
- [Conditional Image Synthesis With Auxiliary Classifier GANs](https://mlsanity.com/paper/1610.09585/) (2016)
- [Reliable Fidelity and Diversity Metrics for Generative Models](https://mlsanity.com/paper/2002.09797/) (2020)
- [GAN-based Synthetic Medical Image Augmentation for increased CNN Performance in Liver Lesion Classification](https://mlsanity.com/paper/1803.01229/) (2018)
- [Deep Convolutional Neural Networks for Computer-Aided Detection: CNN Architectures, Dataset Characteristics and Transfer Learning](https://mlsanity.com/paper/1602.03409/) (2016)
- [Explainable Artificial Intelligence (XAI) 2.0: A Manifesto of Open Challenges and Interdisciplinary Research Directions](https://mlsanity.com/paper/2310.19775/) (2023)
- [Should we really use post-hoc tests based on mean-ranks?](https://mlsanity.com/paper/1505.02288/) (2015)
- [Towards Human-centered Explainable AI: A Survey of User Studies for Model Explanations](https://mlsanity.com/paper/2210.11584/) (2022)
- [CovidGAN: Data Augmentation Using Auxiliary Classifier GAN for Improved Covid-19 Detection](https://mlsanity.com/paper/2103.05094/) (2021)
- [Diverse Image Generation via Self-Conditioned GANs](https://mlsanity.com/paper/2006.10728/) (2020)
- [Deep Learning Approaches for Data Augmentation in Medical Imaging: A Review](https://mlsanity.com/paper/2307.13125/) (2023)
- [Low-Rank Adaptation for Foundation Models: A Comprehensive Review](https://mlsanity.com/paper/2501.00365/) (2024)

## Abstract (arXiv)

Early detection of oral cancer via photographic imaging presents a promising avenue for large-scale oral cavity screening. However, the development of robust deep learning models is frequently hampered by the scarcity of high-quality, annotated datasets. To address this limitation, a novel and well-curated resource, the Photographic Multi-purpose Oral Cancer Imaging (PhotoMOCI) dataset, is introduced for developing models across multiple diagnostic tasks in oral oncology. Then, a comprehensive benchmark study was conducted to investigate how various data augmentation strategies influence the performance of image classifiers. Our analysis spans different generative AI frameworks, evaluating the efficacy of traditional methods against advanced generative approaches, including Generative Adversarial Networks (GANs) and Diffusion Models (DMs). Additionally, we propose the Synthetic Image Filter (SIF), a mechanism to select specific samples based on two auxiliary models: Synthetic Proxy Classifier to ensure samples are representative of the target class and Synthetic Image Detector to verify they appear realistic, thereby selecting only the high-utility images that contribute to improving downstream performance. Across the evaluated datasets and classifiers, the best SIF-filtered setup improves accuracy over traditional augmentation in all cases, with gains of +1.73% and +2.35% on PhotoMOCI and +2.38% and +2.08% on KOCD for ResNet50 and ViT, respectively. Our findings reveal that while the direct application of generative data augmentation may yield performance drops, the integration of SIF, considering (i) how synthetic data looks real and (ii) how it reflects the discriminative features of the belonging class, provides a simple yet effective mechanism to filter out synthetic samples that confuse the classifier during training.