# InfiMed2: A Generalist Medical Multimodal Foundation Model from Contextual Evidence and Stability-Aware Supervision

arXiv: https://arxiv.org/abs/2609.34798 · HTML: https://mlsanity.com/paper/2609.34798/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 26 of its 30 references that are in the map.
- First posted on arXiv 28 Sep 2026.

## Builds on (most cited first, 26 of 26)

- [Qwen3 Technical Report](https://mlsanity.com/paper/2505.09388/) (2025)
- [Self-Consistency Improves Chain of Thought Reasoning in Language Models](https://mlsanity.com/paper/2203.11171/) (2022)
- [Qwen3-VL Technical Report](https://mlsanity.com/paper/2511.21631/) (2025)
- [MMMU: A Massive Multi-discipline Multimodal Understanding and Reasoning Benchmark for Expert AGI](https://mlsanity.com/paper/2311.16502/) (2023)
- [What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Exams](https://mlsanity.com/paper/2009.13081/) (2020)
- [LLaVA-Med: Training a Large Language-and-Vision Assistant for Biomedicine in One Day](https://mlsanity.com/paper/2306.00890/) (2023)
- [Semantic Uncertainty: Linguistic Invariances for Uncertainty Estimation in Natural Language Generation](https://mlsanity.com/paper/2302.09664/) (2023)
- [BiomedCLIP: a multimodal biomedical foundation model pretrained from fifteen million scientific image-text pairs](https://mlsanity.com/paper/2303.00915/) (2023)
- [MMMU-Pro: A More Robust Multi-discipline Multimodal Understanding Benchmark](https://mlsanity.com/paper/2409.02813/) (2024)
- [MedGemma Technical Report](https://mlsanity.com/paper/2507.05201/) (2025)
- [PMC-VQA: Visual Instruction Tuning for Medical Visual Question Answering](https://mlsanity.com/paper/2305.10415/) (2023)
- [OBELICS: An Open Web-Scale Filtered Dataset of Interleaved Image-Text Documents](https://mlsanity.com/paper/2306.16527/) (2023)
- [MinerU: An Open-Source Solution for Precise Document Content Extraction](https://mlsanity.com/paper/2409.18839/) (2024)
- [LLaVA-OneVision-1.5: Fully Open Framework for Democratized Multimodal Training](https://mlsanity.com/paper/2509.23661/) (2025)
- [Lingshu: A Generalist Foundation Model for Unified Multimodal Medical Understanding and Reasoning](https://mlsanity.com/paper/2506.07044/) (2025)
- [MedXpertQA: Benchmarking Expert-Level Medical Reasoning and Understanding](https://mlsanity.com/paper/2501.18362/) (2025)
- [OmniMedVQA: A New Large-Scale Comprehensive Evaluation Benchmark for Medical LVLM](https://mlsanity.com/paper/2402.09181/) (2024)
- [Hulu-Med: A Transparent Generalist Model towards Holistic Medical Vision-Language Understanding](https://mlsanity.com/paper/2510.08668/) (2025)
- [OmniCorpus: A Unified Multimodal Corpus of 10 Billion-Level Images Interleaved with Text](https://mlsanity.com/paper/2406.08418/) (2024)
- [MINT-1T: Scaling Open-Source Multimodal Data by 10x: A Multimodal Dataset with One Trillion Tokens](https://mlsanity.com/paper/2406.11271/) (2024)
- [BIOMEDICA: An Open Biomedical Image-Caption Archive, Dataset, and Vision-Language Models Derived from Scientific Literature](https://mlsanity.com/paper/2501.07171/) (2025)
- [ReasonMed: A 370K Multi-Agent Generated Dataset for Advancing Medical Reasoning](https://mlsanity.com/paper/2506.09513/) (2025)
- [GMAI-VL & GMAI-VL-5.5M: A Large Vision-Language Model and A Comprehensive Multimodal Dataset Towards General Medical AI](https://mlsanity.com/paper/2411.14522/) (2024)
- [MedXIAOHE: A Comprehensive Recipe for Building Medical MLLMs](https://mlsanity.com/paper/2602.12705/) (2026)
- [Synthesizing High-Quality Visual Question Answering from Medical Documents with Generator-Verifier LMMs](https://mlsanity.com/paper/2510.25867/) (2025)
- [Beyond Captions: Context-Grounded Reconstruction for Biomedical Multimodal Continued Pretraining](https://mlsanity.com/paper/2606.01049/) (2026)

## Abstract (arXiv)

Recent medical multimodal models have benefited from larger corpora, broader modality coverage, and stronger reasoning-oriented training, yet effective data design across continued pretraining (CPT) and post-training remains challenging. Medical sources vary substantially in structure, granularity, and information density, and their utility shifts as training progresses from broad knowledge acquisition to late-stage consolidation. Meanwhile, post-training is often dominated by short-form visual question answering, providing limited supervision for informative and answer-consistent explanations. We introduce InfiMed2, a family of 4B and 27B generalist medical multimodal foundation models built around stage-aware data design. We curate a 55.68B-token corpus that combines broad clinical knowledge with context-rich biomedical visual evidence through source-specific processing. Our CPT pipeline first adapts the vision encoder, then builds broad medical knowledge, and finally transitions to an evidence-focused data mixture during learning-rate decay. For supervised fine-tuning (SFT), we regenerate visual question-answering responses using answer stability, answer-masked reconstruction, and correctness-constrained selection to produce more informative and answer-consistent supervision. The 4B model is further optimized with reinforcement learning with verifiable rewards (RLVR). Across five medical multimodal benchmarks, InfiMed2-4B achieves 66.73% mean accuracy after RLVR, surpassing the larger Qwen3.5-9B, while InfiMed2-27B reaches 73.72%, the highest among the evaluated open-weight models.