# Applying Language Models in Clinical Medicine: Recent Trends and Perspectives

arXiv: https://arxiv.org/abs/2609.34780 · HTML: https://mlsanity.com/paper/2609.34780/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 23 of its 30 references that are in the map.
- First posted on arXiv 28 Sep 2026.

## Builds on (most cited first, 23 of 23)

- [ReAct: Synergizing Reasoning and Acting in Language Models](https://mlsanity.com/paper/2210.03629/) (2022)
- [Toolformer: Language Models Can Teach Themselves to Use Tools](https://mlsanity.com/paper/2302.04761/) (2023)
- [MINT: Evaluating LLMs in Multi-turn Interaction with Tools and Language Feedback](https://mlsanity.com/paper/2309.10691/) (2023)
- [MetaTool Benchmark for Large Language Models: Deciding Whether to Use Tools and Which to Use](https://mlsanity.com/paper/2310.03128/) (2023)
- [CRAFT: Customizing LLMs by Creating and Retrieving from Specialized Toolsets](https://mlsanity.com/paper/2309.17428/) (2023)
- [MOTOR: A Time-To-Event Foundation Model For Structured Medical Records](https://mlsanity.com/paper/2301.03150/) (2023)
- [MedCalc-Bench: Evaluating Large Language Models for Medical Calculations](https://mlsanity.com/paper/2406.12036/) (2024)
- [Medformer: A Multi-Granularity Patching Transformer for Medical Time-Series Classification](https://mlsanity.com/paper/2405.19363/) (2024)
- [MedSafetyBench: Evaluating and Improving the Medical Safety of Large Language Models](https://mlsanity.com/paper/2403.03744/) (2024)
- [Tool-Planner: Task Planning with Clusters across Multiple Tools](https://mlsanity.com/paper/2406.03807/) (2024)
- [MedAgentBoard: Benchmarking Multi-Agent Collaboration with Conventional Methods for Diverse Medical Tasks](https://mlsanity.com/paper/2505.12371/) (2025)
- [MediConfusion: Can you trust your AI radiologist? Probing the reliability of multimodal medical foundation models](https://mlsanity.com/paper/2409.15477/) (2024)
- [BingoGuard: LLM Content Moderation Tools with Risk Levels](https://mlsanity.com/paper/2503.06550/) (2025)
- [Eye-gaze Guided Multi-modal Alignment for Medical Representation Learning](https://mlsanity.com/paper/2403.12416/) (2024)
- [PediatricsGPT: Large Language Models as Chinese Medical Assistants for Pediatric Applications](https://mlsanity.com/paper/2405.19266/) (2024)
- [Learning Evolving Tools for Large Language Models](https://mlsanity.com/paper/2410.06617/) (2024)
- [SM3-Text-to-Query: Synthetic Multi-Model Medical Text-to-Query Benchmark](https://mlsanity.com/paper/2411.05521/) (2024)
- [Enhancing Small Medical Learners with Privacy-preserving Contextual Prompting](https://mlsanity.com/paper/2305.12723/) (2023)
- [The Limited Impact of Medical Adaptation of Large Language and Vision-Language Models](https://mlsanity.com/paper/2411.08870/) (2024)
- [FEDMEKI: A Benchmark for Scaling Medical Foundation Models via Federated Knowledge Injection](https://mlsanity.com/paper/2408.09227/) (2024)
- [Reliable and diverse evaluation of LLM medical knowledge mastery](https://mlsanity.com/paper/2409.14302/) (2024)
- [Low-Rank Knowledge Decomposition for Medical Foundation Models](https://mlsanity.com/paper/2404.17184/) (2024)
- [How Can We Diagnose and Treat Bias in Large Language Models for Clinical Decision-Making?](https://mlsanity.com/paper/2410.16574/) (2024)

## Abstract (arXiv)

The use and applicability of artificial intelligence (AI) in medical research and clinical practice has received increasing attention in the literature over recent years. The emergence of large language models (LLMs) has expanded discussions in regards to applications of AI within healthcare. While traditional deep learning based AI applications in medicine have often focused on specific and defined tasks, LLMs offer broader capabilities and flexibility in working with available data,. At the same time of writing, the integration of LLMs into medical settings raises important questions regarding their reliability, accuracy, transparency, safety, and appropriate role in a medical setting. This text presents and discusses recent talks and articles concerning the application of LLMs in medicine, with particular emphasis on their potential utility in research and clinical practice. It considers both the opportunities offered by these technologies and the challenges associated with their implementation, aiming to provide a perspective on the current and emerging role of LLMs within the medical field.