# Explainable Deep Learning of Resting-State Functional Connectomes Reveals Network Biomarkers of Adolescent Intelligence

arXiv: https://arxiv.org/abs/2609.33422 · HTML: https://mlsanity.com/paper/2609.33422/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 10 of its 41 references that are in the map.
- First posted on arXiv 27 Sep 2026.

## Builds on (most cited first, 10 of 10)

- [A Unified Approach to Interpreting Model Predictions](https://mlsanity.com/paper/1705.07874/) (2017)
- [Axiomatic Attribution for Deep Networks](https://mlsanity.com/paper/1703.01365/) (2017)
- [Optuna: A Next-generation Hyperparameter Optimization Framework](https://mlsanity.com/paper/1907.10902/) (2019)
- [Visualizing and Understanding Convolutional Networks](https://mlsanity.com/paper/1311.2901/) (2013)
- [Deeper Insights into Graph Convolutional Networks for Semi-Supervised Learning](https://mlsanity.com/paper/1801.07606/) (2018)
- [Measuring and Relieving the Over-smoothing Problem for Graph Neural Networks from the Topological View](https://mlsanity.com/paper/1909.03211/) (2019)
- [Graph Autoencoders for Embedding Learning in Brain Networks and Major Depressive Disorder Identification](https://mlsanity.com/paper/2107.12838/) (2021)
- [Brain Networks and Intelligence: A Graph Neural Network Based Approach to Resting State fMRI Data](https://mlsanity.com/paper/2311.03520/) (2023)
- [Beyond Over-smoothing: Uncovering the Trainability Challenges in Deep Graph Neural Networks](https://mlsanity.com/paper/2408.03669/) (2024)
- [Accounting for Temporal Variability in Functional Magnetic Resonance Imaging Improves Prediction of Intelligence](https://mlsanity.com/paper/2211.07429/) (2022)

## Abstract (arXiv)

Mapping resting-state brain organization to individual differences in cognitive ability remains a major challenge in population neuroinformatics. Although deep learning enables flexible modeling of brain connectivity, limited interpretability restricts its scientific and clinical utility. To address this objective, we developed an explainable deep learning framework based on sparse projected residual networks to predict fluid, crystallized, and total intelligence from resting-state functional magnetic resonance imaging in 5,285 participants from the Adolescent Brain Cognitive Development study. We incorporated three complementary explainability methods (Integrated Gradients, Gradient Shapley Additive Explanations, and Occlusion) to interpret model behavior. The framework outperformed existing approaches, achieving Pearson correlations of 0.44, 0.58, and 0.56 for fluid, crystallized, and total intelligence, respectively, corresponding to predictive improvements of 6 to 9 percent. All three explainability methods produced near-identical feature rankings (pairwise rank correlations greater than 0.99). Consensus maps revealed a dual-layered functional architecture where primary predictive hubs localized within canonical systems, while the strongest global predictive pathways frequently bypassed these hubs through distributed, long-range relay connections. These findings suggest that intelligence emerges from the interaction between localized computational hubs and distributed communication pathways. Ultimately, these normative network architectures provide clinical reference maps to detect individual deviations, supporting earlier diagnosis, cognitive subtype stratification, and treatment monitoring in atypical neurodevelopment.