# Beyond MSE: Rician Likelihood Denoising for Self-Supervised Cardiac T2 and T1ρ MRI

arXiv: https://arxiv.org/abs/2609.31777 · HTML: https://mlsanity.com/paper/2609.31777/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 12 of its 16 references that are in the map.
- First posted on arXiv 24 Sep 2026.

## Builds on (most cited first, 12 of 12)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [RoFormer: Enhanced Transformer with Rotary Position Embedding](https://mlsanity.com/paper/2104.09864/) (2021)
- [SwinIR: Image Restoration Using Swin Transformer](https://mlsanity.com/paper/2108.10257/) (2021)
- [Restormer: Efficient Transformer for High-Resolution Image Restoration](https://mlsanity.com/paper/2111.09881/) (2021)
- [Beyond a Gaussian Denoiser: Residual Learning of Deep CNN for Image Denoising](https://mlsanity.com/paper/1608.03981/) (2016)
- [Noise2Noise: Learning Image Restoration without Clean Data](https://mlsanity.com/paper/1803.04189/) (2018)
- [Noise2Void - Learning Denoising from Single Noisy Images](https://mlsanity.com/paper/1811.10980/) (2018)
- [Probabilistic Noise2Void: Unsupervised Content-Aware Denoising](https://mlsanity.com/paper/1906.00651/) (2019)
- [Rician likelihood loss for quantitative MRI using self-supervised deep learning](https://mlsanity.com/paper/2307.07072/) (2023)
- [Noise2Contrast: Multi-Contrast Fusion Enables Self-Supervised Tomographic Image Denoising](https://mlsanity.com/paper/2212.04832/) (2022)

## Abstract (arXiv)

Magnetic resonance imaging involves an inherent trade-off among spatial resolution, acquisition time, and noise. This trade-off contributes to long scan times and high cost. Deep learning has improved image denoising, but cardiac MRI remains difficult because high-resolution, rapid acquisitions generally lack corresponding low-noise ground truth. Self-supervised denoising offers a potential solution by learning from noisy image pairs or even single noisy acquisitions. However, we show that Noise2Void-style blind-spot denoising, which uses a mean squared error (MSE) loss and assumes zero-mean, independent and identically distributed (i.i.d.) noise, is poorly suited to MR magnitude images. When applied to short-axis T2-weighted and T1ρ-weighted cardiac MRI with synthetic Rician noise, it produces biased denoised images and biased parametric maps of T2 and T1ρ. To address this limitation, we formulate self-supervised denoising as maximum likelihood estimation under a known Rician noise model. This yields unbiased denoisers that are competitive with supervised baselines.