# Lightweight Vision Transformer-Based U-Net for Brain Tumor Segmentation from MRI

arXiv: https://arxiv.org/abs/2609.29785 · HTML: https://mlsanity.com/paper/2609.29785/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 13 of its 20 references that are in the map.
- First posted on arXiv 24 Sep 2026.

## Builds on (most cited first, 13 of 13)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Swin Transformer: Hierarchical Vision Transformer using Shifted Windows](https://mlsanity.com/paper/2103.14030/) (2021)
- [SegFormer: Simple and Efficient Design for Semantic Segmentation with Transformers](https://mlsanity.com/paper/2105.15203/) (2021)
- [TransUNet: Transformers Make Strong Encoders for Medical Image Segmentation](https://mlsanity.com/paper/2102.04306/) (2021)
- [3D U-Net: Learning Dense Volumetric Segmentation from Sparse Annotation](https://mlsanity.com/paper/1606.06650/) (2016)
- [Swin-Unet: Unet-like Pure Transformer for Medical Image Segmentation](https://mlsanity.com/paper/2105.05537/) (2021)
- [UNETR: Transformers for 3D Medical Image Segmentation](https://mlsanity.com/paper/2103.10504/) (2021)
- [A Survey on Visual Transformer](https://mlsanity.com/paper/2012.12556/) (2020)
- [Deep Learning Based Brain Tumor Segmentation: A Survey](https://mlsanity.com/paper/2007.09479/) (2020)
- [A Hierarchical Feature Constraint to Camouflage Medical Adversarial Attacks](https://mlsanity.com/paper/2012.09501/) (2020)
- [Underwater Image Reconstruction Using a Swin Transformer-Based Generator and PatchGAN Discriminator](https://mlsanity.com/paper/2512.05866/) (2025)

## Abstract (arXiv)

Accurate brain tumor segmentation from Magnetic Resonance Imaging is essential for diagnosis, treatment planning, and surgical guidance. Although Convolutional Neural Networks, particularly UNet, have achieved significant success in medical image segmentation, they often struggle to capture the long-range spatial dependencies required to model tumors with irregular shapes and complex boundaries. This paper proposes a lightweight Vision Transformer UNet that combines the hierarchical feature extraction capability of UNet with the global context modeling of Vision Transformers. The proposed architecture incorporates a compact ViT bottleneck within a U-Net encoder-decoder framework, enabling effective learning of both local and global features while maintaining computational efficiency with only 2.6 million trainable parameters. The model was evaluated on the TCGA LGG MRI Segmentation dataset, achieving a mean Intersection over Union of 0.8100 and a Dice score of 0.8446, outperforming the baseline UNet by 3.75% and 3.15%, respectively. Extensive quantitative and qualitative analyses, including confusion matrix evaluation, precision recall curves, per-image performance distribution, and tumor size dependency analysis, demonstrate the effectiveness and robustness of the proposed method for brain tumor segmentation.