# Deep learning of longitudinal visual fields predicts glaucoma progression rate and identifies fast progressors

arXiv: https://arxiv.org/abs/2609.29256 · HTML: https://mlsanity.com/paper/2609.29256/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 4 of its 24 references that are in the map.
- First posted on arXiv 24 Sep 2026.

## Builds on (most cited first, 4 of 4)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Selective Classification for Deep Neural Networks](https://mlsanity.com/paper/1705.08500/) (2017)
- [Harvard Glaucoma Detection and Progression: A Multimodal Multitask Dataset and Generalization-Reinforced Semi-Supervised Learning](https://mlsanity.com/paper/2308.13411/) (2023)
- [Forecasting Future Humphrey Visual Fields Using Deep Learning](https://mlsanity.com/paper/1804.04543/) (2018)

## Abstract (arXiv)

Glaucoma is the leading cause of irreversible blindness, and timely identification of fast progressors is essential to prevent disability. Current practice estimates progression by ordinary least-squares regression of mean deviation (MD) on time, requiring 6--10 visual field (VF) tests over several years to obtain a reliable slope. We present GLAM (Glaucoma Longitudinal Analysis Model), a deep learning framework that ingests longitudinal Humphrey 24-2 total deviation sequences with five clinical features and predicts MD and visual field index progression rates using attention-based fusion and aleatoric uncertainty. On the open-access University of Washington Humphrey Visual Field dataset (4,276 patient-eyes), GLAM achieved an MD-rate mean absolute error of 0.139 dB yr-1 (R2 = 0.927; 73.5% reduction over a ridge baseline) and an AUC of 0.990 for fast-progressor detection. VF-only deep learning can match multimodal pipelines for progression prognostication using routinely collected perimetry alone.