# MMAP: Multimodal Missing-Aware Pretraining for Longitudinal Alzheimer's Prediction

arXiv: https://arxiv.org/abs/2609.26617 · HTML: https://mlsanity.com/paper/2609.26617/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 18 of its 31 references that are in the map.
- First posted on arXiv 22 Sep 2026.

## Builds on (most cited first, 18 of 18)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [A Simple Framework for Contrastive Learning of Visual Representations](https://mlsanity.com/paper/2002.05709/) (2020)
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- [DINOv3](https://mlsanity.com/paper/2508.10104/) (2025)
- [SigLIP 2: Multilingual Vision-Language Encoders with Improved Semantic Understanding, Localization, and Dense Features](https://mlsanity.com/paper/2502.14786/) (2025)
- [iBOT: Image BERT Pre-Training with Online Tokenizer](https://mlsanity.com/paper/2111.07832/) (2021)
- [Multimodal Prompting with Missing Modalities for Visual Recognition](https://mlsanity.com/paper/2303.03369/) (2023)
- [Image Captioners Are Scalable Vision Learners Too](https://mlsanity.com/paper/2306.07915/) (2023)
- [Best of Both Worlds: Multimodal Contrastive Learning with Tabular and Imaging Data](https://mlsanity.com/paper/2303.14080/) (2023)
- [Isambard-AI: a leadership class supercomputer optimised specifically for Artificial Intelligence](https://mlsanity.com/paper/2410.11199/) (2024)
- [LocCa: Visual Pretraining with Location-aware Captioners](https://mlsanity.com/paper/2403.19596/) (2024)
- [TIP: Tabular-Image Pre-training for Multimodal Classification with Incomplete Data](https://mlsanity.com/paper/2407.07582/) (2024)
- [HyperFusion: A Hypernetwork Approach to Multimodal Integration of Tabular and Medical Imaging Data for Predictive Modeling](https://mlsanity.com/paper/2403.13319/) (2024)
- [Towards Cardiac MRI Foundation Models: Comprehensive Visual-Tabular Representations for Whole-Heart Assessment and Beyond](https://mlsanity.com/paper/2504.13037/) (2025)
- [Multimodal Contrastive Learning and Tabular Attention for Automated Alzheimer's Disease Prediction](https://mlsanity.com/paper/2308.15469/) (2023)
- [DRIM: Learning Disentangled Representations from Incomplete Multimodal Healthcare Data](https://mlsanity.com/paper/2409.17055/) (2024)
- [A Unified Model for Longitudinal Multi-Modal Multi-View Prediction with Missingness](https://mlsanity.com/paper/2403.12211/) (2024)
- [Learning Contrastive Multimodal Fusion with Improved Modality Dropout for Disease Detection and Prediction](https://mlsanity.com/paper/2509.18284/) (2025)

## Abstract (arXiv)

Clinical decision making heavily relies on predicting the disease progression trajectory by seeking to understand patient's health status which is characterised by multimodal medical data. AI holds great potential for learning useful representations from multimodal medical data to predict disease progression and aid clinical decision making. However, development of predictive AI models is constrained by missing modalities and incomplete tabular data frequently occurring in medical datasets. In addition, disease labels alone may only provide limited supervisory signals for learning representations from high-dimensional multimodal data. Here, we present MMAP, a novel Multimodal Missing-aware Alignment Pretraining method for learning image-tabular representations from incomplete data. An image encoder is pretrained with efficient sigmoid contrastive learning combined with generative reconstruction. A tabular encoder is built upon a tabular foundation model. A missing token generator enables the two encoders to take incomplete data as input, enabling the model to be robust against missing modalities, either with missing images or missing tabular data. We evaluate the clinical usefulness of the learnt multimodal representations on two challenging longitudinal clinical tasks for Alzheimer's disease: predicting disease stage conversion and predicting amyloid status. The proposed method outperforms strong multimodal and unimodal baselines.