# Topology-Aware Parameter-Efficient Adaptation for Cross-Dataset Retinal Vessel Segmentation

arXiv: https://arxiv.org/abs/2609.26189 · HTML: https://mlsanity.com/paper/2609.26189/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 9 of its 16 references that are in the map.
- First posted on arXiv 10 Aug 2026.

## Builds on (most cited first, 9 of 9)

- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [UNet++: A Nested U-Net Architecture for Medical Image Segmentation](https://mlsanity.com/paper/1807.10165/) (2018)
- [Attention U-Net: Learning Where to Look for the Pancreas](https://mlsanity.com/paper/1804.03999/) (2018)
- [clDice -- A Novel Topology-Preserving Loss Function for Tubular Structure Segmentation](https://mlsanity.com/paper/2003.07311/) (2020)
- [Medical SAM 2: Segment medical images as video via Segment Anything Model 2](https://mlsanity.com/paper/2408.00874/) (2024)
- [Skeleton Recall Loss for Connectivity Conserving and Resource Efficient Segmentation of Thin Tubular Structures](https://mlsanity.com/paper/2404.03010/) (2024)
- [TopoLoRA-SAM: Topology-Aware Parameter-Efficient Adaptation of Foundation Segmenters for Thin-Structure and Cross-Domain Binary Semantic Segmentation](https://mlsanity.com/paper/2601.02273/) (2026)
- [SAM2LoRA: Composite Loss-Guided, Parameter-Efficient Finetuning of SAM2 for Retinal Fundus Segmentation](https://mlsanity.com/paper/2510.10288/) (2025)
- [VesSAM: Efficient Multi-Prompting for Segmenting Complex Vessel](https://mlsanity.com/paper/2511.00981/) (2025)

## Abstract (arXiv)

Retinal vessel segmentation in multi-domain deployment requires a source model to adapt to domains that differ in imaging conditions and annotation conventions. Conventional parameter-efficient fine-tuning reduces target-specific storage, but its highly restricted adaptation subspace can be insufficient for reconstructing thin, connected vascular structures. We therefore ask how target-specific capacity should be allocated so that topology-aware supervision remains effective under a strict per-domain parameter budget. Based on this principle, we propose TAPDecoderFT, a topology-responsive, role-structured adaptation framework. Specifically, TAPDecoderFT shares a fixed source parameter state across deployment domains, uses low-rank residuals for target-specific private/fusion feature mixing, and retains a trainable dense-reconstruction path comprising the decoder, output head, and refinement module. To promote structurally faithful predictions, the compact target state is jointly optimized with a region-overlap and topology-aware objective that encourages centerline continuity and thin-branch recovery. It improves both DSC and clDice over GenericLoRA-r4 and narrow TAP-r4 in all six directions and is comparable to full fine-tuning.