# Patch-to-Global: Random Patch Diffusion for Globally Consistent Megapixel Artifact Inpainting in Whole Slide Images

arXiv: https://arxiv.org/abs/2609.24116 · HTML: https://mlsanity.com/paper/2609.24116/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 14 of its 27 references that are in the map.
- First posted on arXiv 21 Sep 2026.

## Builds on (most cited first, 14 of 14)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [Densely Connected Convolutional Networks](https://mlsanity.com/paper/1608.06993/) (2016)
- [MobileNetV2: Inverted Residuals and Linear Bottlenecks](https://mlsanity.com/paper/1801.04381/) (2018)
- [Attention-based Deep Multiple Instance Learning](https://mlsanity.com/paper/1802.04712/) (2018)
- [Data Efficient and Weakly Supervised Computational Pathology on Whole Slide Images](https://mlsanity.com/paper/2004.09666/) (2020)
- [Resolution-robust Large Mask Inpainting with Fourier Convolutions](https://mlsanity.com/paper/2109.07161/) (2021)
- [Learned representation-guided diffusion models for large-image generation](https://mlsanity.com/paper/2312.07330/) (2023)
- [CoordFill: Efficient High-Resolution Image Inpainting via Parameterized Coordinate Querying](https://mlsanity.com/paper/2303.08524/) (2023)
- [DiffInfinite: Large Mask-Image Synthesis via Parallel Random Patch Diffusion in Histopathology](https://mlsanity.com/paper/2306.13384/) (2023)
- [Benchmarking the Robustness of Deep Neural Networks to Common Corruptions in Digital Pathology](https://mlsanity.com/paper/2206.14973/) (2022)
- [ZoomLDM: Latent Diffusion Model for multi-scale image generation](https://mlsanity.com/paper/2411.16969/) (2024)
- [Artificial intelligence in digital pathology: a systematic review and meta-analysis of diagnostic test accuracy](https://mlsanity.com/paper/2306.07999/) (2023)
- [Artifact Restoration in Histology Images with Diffusion Probabilistic Models](https://mlsanity.com/paper/2307.14262/) (2023)

## Built on by (most cited first, 1 of 1)

- [The Effect of Tissue Detection on False Positives of Diffusion-Based Artifact Detection in Histopathology](https://mlsanity.com/paper/2609.40083/) (2026)

## Abstract (arXiv)

Although deep learning has advanced Whole Slide Image (WSI) Analysis, tissue artifacts like bubbles and folds often cause silent failures by concealing essential morphology. Current pathology image restoration methods are mostly restricted to small patches, struggling to maintain global structural coherence at a megapixel scale. We introduce RestorePath, a framework for globally consistent megapixel scale inpainting that reconstructs diagnostic structures in histological image to prevent incorrect high-confidence predictions and lower error rates. Our model utilizes a Latent Diffusion Model (LDM) conditioned on Pathology Foundation Model (PFM) embeddings, integrating Large Kernel Attention (LKA) to manage long-range dependencies during random patch diffusion. Enhanced by Distance-Weighted Interpolation (DWI) and an Adaptive Guidance Scale (AGS), RestorePath ensures structural consistency and fidelity by modulating information from surrounding patches. Evaluations across TCGA-BRCA, BACH, and Camelyon16 datasets for images ranging from 512 to 4608 pixels demonstrate state-of-the-art performance in maintaining histological consistency. RestorePath significantly improves downstream Computational Pathology (CP) tasks, outperforming both raw artifact images and the conventional Detect-and-Discard (D&D) approach. The code is available at https://github.com/PathfinderLab/RestorePath