# ORION-CMR: On-scanner Reporting with Integrated Foundation Model for End-to-End Cardiac MRI Analysis and Interpretation

arXiv: https://arxiv.org/abs/2609.23950 · HTML: https://mlsanity.com/paper/2609.23950/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 9 of its 29 references that are in the map.
- First posted on arXiv 20 Sep 2026.

## Builds on (most cited first, 9 of 9)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [DINOv2: Learning Robust Visual Features without Supervision](https://mlsanity.com/paper/2304.07193/) (2023)
- [Emerging Properties in Self-Supervised Vision Transformers](https://mlsanity.com/paper/2104.14294/) (2021)
- [Generalist Foundation Models from a Multimodal Dataset for 3D Computed Tomography](https://mlsanity.com/paper/2403.17834/) (2024)
- [Deep Learning methods for automatic evaluation of delayed enhancement-MRI. The results of the EMIDEC challenge](https://mlsanity.com/paper/2108.04016/) (2021)
- [UltraSam: A Foundation Model for Ultrasound using Large Open-Access Segmentation Datasets](https://mlsanity.com/paper/2411.16222/) (2024)
- [Towards a vision foundation model for comprehensive assessment of Cardiac MRI](https://mlsanity.com/paper/2410.01665/) (2024)
- [Towards Cardiac MRI Foundation Models: Comprehensive Visual-Tabular Representations for Whole-Heart Assessment and Beyond](https://mlsanity.com/paper/2504.13037/) (2025)

## Abstract (arXiv)

Cardiovascular magnetic resonance (CMR) provides comprehensive cardiac assessment but remains underutilized because of the complexity of acquisition, post-processing, and interpretation. Existing artificial intelligence (AI) methods address isolated tasks, limiting clinical integration. We present ORION-CMR (On-scanner Reporting with Integrated fOunda-tioN Model), the first clinically evaluated scanner-native end-to-end CMR foundation model. Pretrained on 12,896,733 CMR images from 9,258 studies, ORION-CMR performs sequence classification, ventricular function assessment, late gadolinium enhancement (LGE) detection, binary and multiclass disease classification, and local large language model-based report generation in approximately 90 seconds. The framework. was evaluated on public benchmarks and clinically validated in a multi-vendor cohort of 68 subjects with normal examinations, congenital heart disease, dilated cardiomyopathy, and myocardial infarction. ORION-CMR outperformed supervised baselines and the previously published CMR foundation model (CMR-FM), achieving state-of-the-art performance for LGE classification and scar segmentation. Clinical evaluation achieved an AUC of 0.96 for normal-versus abnormal classification and 0.88 for multiclass disease classification, while generated reports demonstrated 81.4% agreement with expert interpretation. These results demonstrate the feasibility of real-time scanner-native AI-assisted CMR analysis and automated report generation.