# Large language models in medical time series analysis

arXiv: https://arxiv.org/abs/2609.22262 · HTML: https://mlsanity.com/paper/2609.22262/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 154 of its 254 references that are in the map.
- First posted on arXiv 7 Sep 2026.

## Builds on (most cited first, 30 of 154)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Language Models are Few-Shot Learners](https://mlsanity.com/paper/2005.14165/) (2020)
- [Training language models to follow instructions with human feedback](https://mlsanity.com/paper/2203.02155/) (2022)
- [ReAct: Synergizing Reasoning and Acting in Language Models](https://mlsanity.com/paper/2210.03629/) (2022)
- [Visual Instruction Tuning](https://mlsanity.com/paper/2304.08485/) (2023)
- [Scaling Laws for Neural Language Models](https://mlsanity.com/paper/2001.08361/) (2020)
- [BART: Denoising Sequence-to-Sequence Pre-training for Natural Language Generation, Translation, and Comprehension](https://mlsanity.com/paper/1910.13461/) (2019)
- [PaLM: Scaling Language Modeling with Pathways](https://mlsanity.com/paper/2204.02311/) (2022)
- [GPT-4o System Card](https://mlsanity.com/paper/2410.21276/) (2024)
- [Parameter-Efficient Transfer Learning for NLP](https://mlsanity.com/paper/1902.00751/) (2019)
- [Qwen2-VL: Enhancing Vision-Language Model's Perception of the World at Any Resolution](https://mlsanity.com/paper/2409.12191/) (2024)
- [Prefix-Tuning: Optimizing Continuous Prompts for Generation](https://mlsanity.com/paper/2101.00190/) (2021)
- [Gemini 2.5: Pushing the Frontier with Advanced Reasoning, Multimodality, Long Context, and Next Generation Agentic Capabilities](https://mlsanity.com/paper/2507.06261/) (2025)
- [The Power of Scale for Parameter-Efficient Prompt Tuning](https://mlsanity.com/paper/2104.08691/) (2021)
- [OPT: Open Pre-trained Transformer Language Models](https://mlsanity.com/paper/2205.01068/) (2022)
- [QLoRA: Efficient Finetuning of Quantized LLMs](https://mlsanity.com/paper/2305.14314/) (2023)
- [Qwen Technical Report](https://mlsanity.com/paper/2309.16609/) (2023)
- [Gemini 1.5: Unlocking multimodal understanding across millions of tokens of context](https://mlsanity.com/paper/2403.05530/) (2024)
- [Scaling Instruction-Finetuned Language Models](https://mlsanity.com/paper/2210.11416/) (2022)
- [BEiT: BERT Pre-Training of Image Transformers](https://mlsanity.com/paper/2106.08254/) (2021)
- [BioBERT: a pre-trained biomedical language representation model for biomedical text mining](https://mlsanity.com/paper/1901.08746/) (2019)
- [Large Language Models Encode Clinical Knowledge](https://mlsanity.com/paper/2212.13138/) (2022)
- [Gemma 3 Technical Report](https://mlsanity.com/paper/2503.19786/) (2025)
- [Visual Prompt Tuning](https://mlsanity.com/paper/2203.12119/) (2022)
- [Jailbroken: How Does LLM Safety Training Fail?](https://mlsanity.com/paper/2307.02483/) (2023)
- [CoCa: Contrastive Captioners are Image-Text Foundation Models](https://mlsanity.com/paper/2205.01917/) (2022)
- [ViLT: Vision-and-Language Transformer Without Convolution or Region Supervision](https://mlsanity.com/paper/2102.03334/) (2021)
- [LaMDA: Language Models for Dialog Applications](https://mlsanity.com/paper/2201.08239/) (2022)
- [Qwen2.5-Coder Technical Report](https://mlsanity.com/paper/2409.12186/) (2024)
- [ChatGLM: A Family of Large Language Models from GLM-130B to GLM-4 All Tools](https://mlsanity.com/paper/2406.12793/) (2024)

## Abstract (arXiv)

Medical time series (MedTS), including electrocardiograms (ECG), electroencephalograms (EEG), photoplethysmography (PPG), and vital-sign recordings, are central to clinical diagnosis and health monitoring. As large language models (LLMs) have advanced, a growing body of work has examined how their reasoning, generation, and knowledge-integration capabilities can support MedTS analysis. Yet existing studies remain scattered, and the field still lacks a clear view of how these models should be designed, integrated into clinical workflows, and evaluated. This review synthesizes recent work on large language models for medical time series analysis (MedTSLLMs), covering both methodological progress and issues related to real-world deployment. We review model architectures, data resources, and processing pipelines, and prompt design strategies adapted for diverse clinical scenarios. We further organize existing MedTS applications, ranging from diagnostic interpretation and report generation to longitudinal health monitoring and physiological signal synthesis, highlighting task-specific design choices, common evaluation protocols, and empirical findings reported across studies. By bringing together current practices and open challenges, this review aims to provide a clearer foundation for developing, evaluating, and deploying MedTSLLMs responsibly in healthcare. We also maintain a regularly updated list of MedTSLLM studies and resources at: https://github.com/hy727/MedTSLLM-Review.