# Dose-Aware Cold Diffusion with Physics Consistency for Generalizable Low-Dose CT Reconstruction

arXiv: https://arxiv.org/abs/2609.18943 · HTML: https://mlsanity.com/paper/2609.18943/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 22 of its 38 references that are in the map.
- First posted on arXiv 15 Jul 2026.

## Builds on (most cited first, 22 of 22)

- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [Diffusion Models Beat GANs on Image Synthesis](https://mlsanity.com/paper/2105.05233/) (2021)
- [Scalable Diffusion Models with Transformers](https://mlsanity.com/paper/2212.09748/) (2022)
- [Improved Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2102.09672/) (2021)
- [Supervised Contrastive Learning](https://mlsanity.com/paper/2004.11362/) (2020)
- [DPM-Solver: A Fast ODE Solver for Diffusion Probabilistic Model Sampling in Around 10 Steps](https://mlsanity.com/paper/2206.00927/) (2022)
- [Palette: Image-to-Image Diffusion Models](https://mlsanity.com/paper/2111.05826/) (2021)
- [ILVR: Conditioning Method for Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2108.02938/) (2021)
- [Improving Diffusion Models for Inverse Problems using Manifold Constraints](https://mlsanity.com/paper/2206.00941/) (2022)
- [Cold Diffusion: Inverting Arbitrary Image Transforms Without Noise](https://mlsanity.com/paper/2208.09392/) (2022)
- [A Variational Perspective on Solving Inverse Problems with Diffusion Models](https://mlsanity.com/paper/2305.04391/) (2023)
- [Solving 3D Inverse Problems using Pre-trained 2D Diffusion Models](https://mlsanity.com/paper/2211.10655/) (2022)
- [Decomposed Diffusion Sampler for Accelerating Large-Scale Inverse Problems](https://mlsanity.com/paper/2303.05754/) (2023)
- [Diffusion Probabilistic Models beat GANs on Medical Images](https://mlsanity.com/paper/2212.07501/) (2022)
- [Rank-N-Contrast: Learning Continuous Representations for Regression](https://mlsanity.com/paper/2210.01189/) (2022)
- [Residual Denoising Diffusion Models](https://mlsanity.com/paper/2308.13712/) (2023)
- [CoreDiff: Contextual Error-Modulated Generalized Diffusion Model for Low-Dose CT Denoising and Generalization](https://mlsanity.com/paper/2304.01814/) (2023)
- [Cold Diffusion for Speech Enhancement](https://mlsanity.com/paper/2211.02527/) (2022)
- [ASCON: Anatomy-aware Supervised Contrastive Learning Framework for Low-dose CT Denoising](https://mlsanity.com/paper/2307.12225/) (2023)
- [Noise-Inspired Diffusion Model for Generalizable Low-Dose CT Reconstruction](https://mlsanity.com/paper/2506.22012/) (2025)
- [Cross-view Generalized Diffusion Model for Sparse-view CT Reconstruction](https://mlsanity.com/paper/2508.10313/) (2025)
- [FoundDiff: Foundational Diffusion Model for Generalizable Low-Dose CT Denoising](https://mlsanity.com/paper/2508.17299/) (2025)

## Abstract (arXiv)

Reducing radiation dose in computed tomography significantly degrades image quality and poses challenges for accurate and clinically reliable reconstruction. While recent approaches have shown promise for low-dose CT, they often struggle to generalize across continuous and previously unseen dose levels, leading to artifacts and loss of anatomical detail. To address these limitations, we propose Dose-Aware Cold Diffusion (DACD), a physics-consistent reconstruction framework that explicitly models radiation dose as a continuous latent factor within a cold diffusion process. The proposed DACD framework integrates image-based dose-aware perception, multi-scale structural prior extraction, and dose-calibrated step allocation to adaptively guide the denoising trajectory. In addition, an iterative forward-backprojection correction is incorporated into the reverse refinement process to enforce projection-domain data consistency. Extensive experiments on three public benchmarks, including Mayo-2020, Mayo-2016, and LoDoPaB-CT, demonstrate that DACD consistently outperforms state-of-the-art diffusion-based and physics-guided methods in both quantitative accuracy and visual fidelity, particularly under ultra-low-dose conditions. The results show that DACD achieves robust generalization across a continuous range of dose levels, including those unseen during training.