# Collective Loss of Control in LLM Agent Systems: An Epidemic Account of Mutation, Contagion, and Recovery

arXiv: https://arxiv.org/abs/2609.18460 · HTML: https://mlsanity.com/paper/2609.18460/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Agent threats, guardrails and governance, one of 16 directions in LLM agents and tool use.
- Builds on 35 of its 57 references that are in the map.
- First posted on arXiv 16 Sep 2026.

## Placed in

- LLM agents and tool use / [Agent threats, guardrails and governance](https://mlsanity.com/agents/agent-threats-guardrails-and-governance/)

## Builds on (most cited first, 30 of 35)

- [ReAct: Synergizing Reasoning and Acting in Language Models](https://mlsanity.com/paper/2210.03629/) (2022)
- [Reflexion: Language Agents with Verbal Reinforcement Learning](https://mlsanity.com/paper/2303.11366/) (2023)
- [Self-Refine: Iterative Refinement with Self-Feedback](https://mlsanity.com/paper/2303.17651/) (2023)
- [AutoGen: Enabling Next-Gen LLM Applications via Multi-Agent Conversation](https://mlsanity.com/paper/2308.08155/) (2023)
- [MetaGPT: Meta Programming for A Multi-Agent Collaborative Framework](https://mlsanity.com/paper/2308.00352/) (2023)
- [Concrete Problems in AI Safety](https://mlsanity.com/paper/1606.06565/) (2016)
- [Not what you've signed up for: Compromising Real-World LLM-Integrated Applications with Indirect Prompt Injection](https://mlsanity.com/paper/2302.12173/) (2023)
- [τ-bench: A Benchmark for Tool-Agent-User Interaction in Real-World Domains](https://mlsanity.com/paper/2406.12045/) (2024)
- [CAMEL: Communicative Agents for "Mind" Exploration of Large Language Model Society](https://mlsanity.com/paper/2303.17760/) (2023)
- [Large Language Models Cannot Self-Correct Reasoning Yet](https://mlsanity.com/paper/2310.01798/) (2023)
- [An Explanation of In-context Learning as Implicit Bayesian Inference](https://mlsanity.com/paper/2111.02080/) (2021)
- [Identifying the Risks of LM Agents with an LM-Emulated Sandbox](https://mlsanity.com/paper/2309.15817/) (2023)
- [InjecAgent: Benchmarking Indirect Prompt Injections in Tool-Integrated Large Language Model Agents](https://mlsanity.com/paper/2403.02691/) (2024)
- [Sleeper Agents: Training Deceptive LLMs that Persist Through Safety Training](https://mlsanity.com/paper/2401.05566/) (2024)
- [The Instruction Hierarchy: Training LLMs to Prioritize Privileged Instructions](https://mlsanity.com/paper/2404.13208/) (2024)
- [AgentHarm: A Benchmark for Measuring Harmfulness of LLM Agents](https://mlsanity.com/paper/2410.09024/) (2024)
- [AgentPoison: Red-teaming LLM Agents via Poisoning Memory or Knowledge Bases](https://mlsanity.com/paper/2407.12784/) (2024)
- [Alignment faking in large language models](https://mlsanity.com/paper/2412.14093/) (2024)
- [Function Vectors in Large Language Models](https://mlsanity.com/paper/2310.15213/) (2023)
- [Defeating Prompt Injections by Design](https://mlsanity.com/paper/2503.18813/) (2025)
- [ToolSandbox: A Stateful, Conversational, Interactive Evaluation Benchmark for LLM Tool Use Capabilities](https://mlsanity.com/paper/2408.04682/) (2024)
- [R-Judge: Benchmarking Safety Risk Awareness for LLM Agents](https://mlsanity.com/paper/2401.10019/) (2024)
- [When Can LLMs Actually Correct Their Own Mistakes? A Critical Survey of Self-Correction of LLMs](https://mlsanity.com/paper/2406.01297/) (2024)
- [Agent Smith: A Single Image Can Jailbreak One Million Multimodal LLM Agents Exponentially Fast](https://mlsanity.com/paper/2402.08567/) (2024)
- [Prompt Infection: LLM-to-LLM Prompt Injection within Multi-Agent Systems](https://mlsanity.com/paper/2410.07283/) (2024)
- [BadAgent: Inserting and Activating Backdoor Attacks in LLM Agents](https://mlsanity.com/paper/2406.03007/) (2024)
- [On the Resilience of LLM-Based Multi-Agent Collaboration with Faulty Agents](https://mlsanity.com/paper/2408.00989/) (2024)
- [PsySafe: A Comprehensive Framework for Psychological-based Attack, Defense, and Evaluation of Multi-agent System Safety](https://mlsanity.com/paper/2401.11880/) (2024)
- [MemoryGraft: Persistent Compromise of LLM Agents via Poisoned Experience Retrieval](https://mlsanity.com/paper/2512.16962/) (2025)
- [Large Language Models have Intrinsic Self-Correction Ability](https://mlsanity.com/paper/2406.15673/) (2024)

## Abstract (arXiv)

How does a multi-agent system evolve from a local deviation into collective loss of control? We propose an epidemic explanation organized around accidental mutation, contagion, and recovery. A spontaneous deviation creates a seed; communication enables other agents to adopt and retransmit its unsafe strategy; collective failure can emerge when propagation outpaces correction and containment. Thus, rare individual deviations can coexist with substantial collective risk. Motivated by reported OpenAI agent coordination incidents, we examine two ingredients of this mechanism. A deployment audit identifies implicit communication paths between nominally independent evaluation runs and verifies transport through a default Docker backend. RogueHandoff-20, a benchmark of 20 executable scenarios, tests recipient susceptibility by injecting unsafe trajectories generated by a modified Qwen-27B route. Across four native-pending routes, executed harm is 0-5% on normal tasks and 40-95% after injection, exceeding paired direct malicious requests by 5-45 percentage points. These results support low observed baseline harm alongside high conditional susceptibility; they do not establish natural rare-event rates or demonstrate an autonomous cascade. The account motivates complementary defenses: strengthen resistance and recovery alongside prevention of spontaneous deviations, and audit and restrict unintended communication paths that can turn local failures into collective loss of control.