# EMR: Self-Evolving Medical Multi-Agent System via Experience Mining and Reuse

arXiv: https://arxiv.org/abs/2609.15161 · HTML: https://mlsanity.com/paper/2609.15161/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Placed in Medical and scientific domain agents, one of 16 directions in LLM agents and tool use.
- Builds on 21 of its 44 references that are in the map.
- First posted on arXiv 14 Sep 2026.

## Placed in

- LLM agents and tool use / [Medical and scientific domain agents](https://mlsanity.com/agents/medical-and-scientific-domain-agents/)
- Synthetic data and self-improvement for LLMs / [Medical synthetic data and agents](https://mlsanity.com/synth/medical-synthetic-data-and-agents/)

## Builds on (most cited first, 21 of 21)

- [Measuring Massive Multitask Language Understanding](https://mlsanity.com/paper/2009.03300/) (2020)
- [Large Language Models are Zero-Shot Reasoners](https://mlsanity.com/paper/2205.11916/) (2022)
- [MMLU-Pro: A More Robust and Challenging Multi-Task Language Understanding Benchmark](https://mlsanity.com/paper/2406.01574/) (2024)
- [What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Exams](https://mlsanity.com/paper/2009.13081/) (2020)
- [PubMedQA: A Dataset for Biomedical Research Question Answering](https://mlsanity.com/paper/1909.06146/) (2019)
- [ExpeL: LLM Agents Are Experiential Learners](https://mlsanity.com/paper/2308.10144/) (2023)
- [Agentic Context Engineering: Evolving Contexts for Self-Improving Language Models](https://mlsanity.com/paper/2510.04618/) (2025)
- [MedAgents: Large Language Models as Collaborators for Zero-shot Medical Reasoning](https://mlsanity.com/paper/2311.10537/) (2023)
- [ReConcile: Round-Table Conference Improves Reasoning via Consensus among Diverse LLMs](https://mlsanity.com/paper/2309.13007/) (2023)
- [Multi-agent Architecture Search via Agentic Supernet](https://mlsanity.com/paper/2502.04180/) (2025)
- [AgentSquare: Automatic LLM Agent Search in Modular Design Space](https://mlsanity.com/paper/2410.06153/) (2024)
- [AI Hospital: Benchmarking Large Language Models in a Multi-agent Medical Interaction Simulator](https://mlsanity.com/paper/2402.09742/) (2024)
- [FLEX: Continuous Agent Evolution via Forward Learning from Experience](https://mlsanity.com/paper/2511.06449/) (2025)
- [Self-Evolving Multi-Agent Simulations for Realistic Clinical Interactions](https://mlsanity.com/paper/2503.22678/) (2025)
- [MDTeamGPT: A Self-Evolving LLM-based Multi-Agent Framework for Multi-Disciplinary Team Medical Consultation](https://mlsanity.com/paper/2503.13856/) (2025)
- [Unified attacks to large language model watermarks: spoofing and scrubbing in unauthorized knowledge distillation](https://mlsanity.com/paper/2504.17480/) (2025)
- [Are Tools All We Need? Unveiling the Tool-Use Tax in LLM Agents](https://mlsanity.com/paper/2605.00136/) (2026)
- [Leveraging Multi-AI Agents for Cross-Domain Knowledge Discovery](https://mlsanity.com/paper/2404.08511/) (2024)
- [Hierarchical Safety Realignment: Lightweight Restoration of Safety in Pruned Large Vision-Language Models](https://mlsanity.com/paper/2505.16104/) (2025)
- [SURGENT: A Surgical Multi-Agent Assistance System Across the Perioperative Workflow](https://mlsanity.com/paper/2605.29368/) (2026)
- [Reinforcement Learning for Large Language Model Selective Evidence Adoption from Contaminated Retrieval Results](https://mlsanity.com/paper/2607.20090/) (2026)

## Built on by (most cited first, 1 of 1)

- [AsynCodeBench: Benchmarking Collaboration of Asynchronous Multi-Agent Systems in Software Engineering](https://mlsanity.com/paper/2609.32662/) (2026)

## Abstract (arXiv)

Large language model (LLM) driven multi-agent systems have shown promise in complex clinical reasoning, yet existing approaches rely on static strategies and lack persistent clinical memory, preventing self-evolving from prior diagnostic successes and failures. We present EMR, a self-evolving medical multi-agent system via Experience Mining and Reuse. EMR introduces a hierarchical clinical experience library that organizes accumulated knowledge into three levels: clinical principles, diagnostic patterns, and representative cases. During inference, EMR emulates multidisciplinary consultation: a planner agent coordinates domain-specific department agents for specialized reasoning, while a summary agent synthesizes their analyses into a final decision. Critically, EMR automatically extracts correct diagnostic insights and failure-related warnings from multi-agent reasoning trajectories, incrementally updating the experience library to guide future cases. Experiments on medical reasoning benchmarks demonstrate that EMR consistently outperforms state-of-the-art medical multi-agent baselines. Further analysis reveals that the hierarchical experience enables cross-specialty generalization and transfer across diverse LLM backbones, offering a scalable and in