# A Voxel-Spacing-Aware Extension of PyRadiomics for Anisotropic Texture Analysis

arXiv: https://arxiv.org/abs/2609.14103 · HTML: https://mlsanity.com/paper/2609.14103/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 1 of its 13 references that are in the map.
- First posted on arXiv 12 Sep 2026.

## Builds on (most cited first, 1 of 1)

- [Image biomarker standardisation initiative](https://mlsanity.com/paper/1612.07003/) (2016)

## Abstract (arXiv)

Radiomic texture features are commonly extracted from anisotropic CT and MRI acquisitions, where identical voxel offsets may represent different physical distances. We implemented and validated a voxel-spacing-aware extension of PyRadiomics that incorporates spacing information without generating interpolated gray levels. The framework operates across the Python frontend, C wrapper, and computational backend. GLCM uses anisotropy-relative feature-level angular aggregation, NGTDM uses anisotropy-relative weighted neighborhood averaging, and GLRLM, GLDM, and GLSZM are computed on a finite-volume zero-order-hold representation derived from the native anisotropic grid. Synthetic 3D phantoms were used for software validation. The modified implementation reproduced standard PyRadiomics exactly when spacing-aware mode was disabled and remained equivalent under isotropic spacing across 75 texture features. Under anisotropic spacing, the method selectively modified texture families and was numerically distinct from nearest-neighbor, linear, and B-spline resampling. Computational profiling showed moderate runtime and memory increases, while sensitivity analyses quantified finite-volume rounding effects and confirmed that spacing-aware differences persisted across binWidth settings. The framework provides a backward-compatible technical basis for future evaluation of spacing-aware radiomics in heterogeneous medical imaging datasets.