# Unified Multi-Layer Subspace Modeling for Cross-Domain OOD Detection

arXiv: https://arxiv.org/abs/2609.06785 · HTML: https://mlsanity.com/paper/2609.06785/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 54 of its 82 references that are in the map.
- First posted on arXiv 6 Sep 2026.

## Builds on (most cited first, 30 of 54)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [PyTorch: An Imperative Style, High-Performance Deep Learning Library](https://mlsanity.com/paper/1912.01703/) (2019)
- [Swin Transformer: Hierarchical Vision Transformer using Shifted Windows](https://mlsanity.com/paper/2103.14030/) (2021)
- [Masked Autoencoders Are Scalable Vision Learners](https://mlsanity.com/paper/2111.06377/) (2021)
- [Fashion-MNIST: a Novel Image Dataset for Benchmarking Machine Learning Algorithms](https://mlsanity.com/paper/1708.07747/) (2017)
- [Zero-Shot Text-to-Image Generation](https://mlsanity.com/paper/2102.12092/) (2021)
- [A ConvNet for the 2020s](https://mlsanity.com/paper/2201.03545/) (2022)
- [A Baseline for Detecting Misclassified and Out-of-Distribution Examples in Neural Networks](https://mlsanity.com/paper/1610.02136/) (2016)
- [Describing Textures in the Wild](https://mlsanity.com/paper/1311.3618/) (2013)
- [A Simple Unified Framework for Detecting Out-of-Distribution Samples and Adversarial Attacks](https://mlsanity.com/paper/1807.03888/) (2018)
- [Enhancing The Reliability of Out-of-distribution Image Detection in Neural Networks](https://mlsanity.com/paper/1706.02690/) (2017)
- [Energy-based Out-of-distribution Detection](https://mlsanity.com/paper/2010.03759/) (2020)
- [A Closer Look at Spatiotemporal Convolutions for Action Recognition](https://mlsanity.com/paper/1711.11248/) (2017)
- [Generalized Out-of-Distribution Detection: A Survey](https://mlsanity.com/paper/2110.11334/) (2021)
- [Universal adversarial perturbations](https://mlsanity.com/paper/1610.08401/) (2016)
- [Deep Neural Networks are Easily Fooled: High Confidence Predictions for Unrecognizable Images](https://mlsanity.com/paper/1412.1897/) (2014)
- [The Medical Segmentation Decathlon](https://mlsanity.com/paper/2106.05735/) (2021)
- [Out-of-Distribution Detection with Deep Nearest Neighbors](https://mlsanity.com/paper/2204.06507/) (2022)
- [Kvasir-SEG: A Segmented Polyp Dataset](https://mlsanity.com/paper/1911.07069/) (2019)
- [The RSNA-ASNR-MICCAI BraTS 2021 Benchmark on Brain Tumor Segmentation and Radiogenomic Classification](https://mlsanity.com/paper/2107.02314/) (2021)
- [ReAct: Out-of-distribution Detection With Rectified Activations](https://mlsanity.com/paper/2111.12797/) (2021)
- [Scaling Out-of-Distribution Detection for Real-World Settings](https://mlsanity.com/paper/1911.11132/) (2019)
- [ViM: Out-Of-Distribution with Virtual-logit Matching](https://mlsanity.com/paper/2203.10807/) (2022)
- [A large annotated medical image dataset for the development and evaluation of segmentation algorithms](https://mlsanity.com/paper/1902.09063/) (2019)
- [EndoNet: A Deep Architecture for Recognition Tasks on Laparoscopic Videos](https://mlsanity.com/paper/1602.03012/) (2016)
- [Open-Set Recognition: a Good Closed-Set Classifier is All You Need?](https://mlsanity.com/paper/2110.06207/) (2021)
- [Why ReLU networks yield high-confidence predictions far away from the training data and how to mitigate the problem](https://mlsanity.com/paper/1812.05720/) (2018)
- [CHAOS Challenge -- Combined (CT-MR) Healthy Abdominal Organ Segmentation](https://mlsanity.com/paper/2001.06535/) (2020)
- [Unsolved Problems in ML Safety](https://mlsanity.com/paper/2109.13916/) (2021)

## Abstract (arXiv)

Out-of-Distribution (OOD) detection remains a fundamental challenge for neural networks, whose predictions can be overconfident on inputs that deviate from the training distribution. Most post-hoc OOD detection methods derive scores from a single representation level (eg., logits or penultimate features) or combine multiple layers via depth selection or OOD-calibrated weighting. However, because OOD shifts are diverse, the most informative representation level can vary strongly across OOD types and domains, making fixed-layer choices and OOD-calibrated aggregation brittle. In this paper, we propose PRISM (Projected Representation with Intermediate-layer Subspace Modeling), a model-agnostic post-hoc OOD detection method that models a unified multi-layer feature representation rather than aggregating independently scored layers. PRISM fuses intermediate and deep features into a single hierarchical embedding, estimates an in-distribution (ID) principal subspace, and then combines two complementary signals: (i) a class-conditional Mahalanobis distance in the projected subspace and (ii) the residual energy orthogonal to the learned manifold. This simple design avoids OOD-tuned layer weighting while capturing both in-subspace semantic deviations and off-subspace anomalies. Across diverse benchmarks spanning natural images, medical imaging, and industrial visual inspection, PRISM achieves consistent state-of-the-art cross-domain OOD detection performance with a single default configuration across all evaluated domains and architectures. We further show that PRISM incurs minimal inference overhead, making it practical for real-world deployment.